Andarine
Scientific names: Andarine
Alternate names: (S)-3-(4-acetylamino-phenoxy)-2-hydroxy2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide, Acetamidoxolutamide, Androxolutamide, GTx-007, SARM-S4, S4
Actions: General, Androgenic
Background
Andarine is an investigational drug that has not yet been approved by the US Food and Drug Administration (FDA). It is part of a class of drugs called selective androgen receptor modulators (SARMs). Some supplement companies have included andarine in products for bodybuilding. The FDA considers supplements containing andarine to be illegal.
People use andarine to improve athletic performance and for conditions such as involuntary weight loss in people who are very ill (cachexia or wasting syndrome), osteoporosis, and prostate health, but there is no good scientific evidence to support these uses. Using andarine can also be unsafe.
People use andarine to improve athletic performance and for conditions such as involuntary weight loss in people who are very ill (cachexia or wasting syndrome), osteoporosis, and prostate health, but there is no good scientific evidence to support these uses. Using andarine can also be unsafe.
Safety Safety definitions
When taken by mouth: Andarine is POSSIBLY UNSAFE. Liver damage, heart attack, and stroke have been reported in some people taking drugs like andarine.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if andarine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Insufficient evidence Effectiveness definitions
- Age-related muscle loss (sarcopenia).
- Athletic performance.
- Enlarged prostate (benign prostatic hyperplasia or BPH).
- Involuntary weight loss in people who are very ill (cachexia or wasting syndrome).
- Osteoporosis.
- Prostate cancer.
- Other conditions.
Dosing & administration
The appropriate dose of andarine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for andarine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Interactions with pharmaceuticals
It is not known if Andarine interacts with any medicines. Before taking Andarine, talk with your healthcare professional if you take any medications.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Action
Andarine attaches to proteins in the body known as androgen receptors. When andarine binds to these receptors, it tells the muscles and bones in the body to grow. Unlike some other chemicals that bind to androgen receptors, such as steroids, andarine doesn't seem to cause as many side effects in other parts of the body.
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This monograph was last reviewed on 31/05/2023 10:00:00. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
