Androstenediol
Alternate names: 4-AD; 4-Androstenediol; 4-Androstènediol, 5-AD; 5-Androstenediol; 5-Androstènediol; Androdiol; Androstènediol
Actions: Antineoplastic activity, Body building, Hormone regulation activity, Immunostimulation activity, Lipid lowering (HDL-C) activity, Mood enhancement, Sexual activity enhancement
Background
Androstenediol is a type of chemical known as a steroid. It is converted in the body to testosterone and other sex hormones.
Androstenediol used to be available as a dietary supplement in the U.S. But it has been reclassified as a schedule III controlled substance. This means androstenediol is available only as a prescription medicine, and physicians have to follow strict rules when prescribing it. It is banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA) for use by athletes.
Androstenediol is used to increase testosterone levels in the body to improve athletic performance, to enhance response to sexual stimuli in healthy people, to improve sexual problems that prevent satisfaction during sexual activity, and other conditions, but there is no good scientific evidence to support these uses. Androstendiol might also be unsafe.
Androstenediol used to be available as a dietary supplement in the U.S. But it has been reclassified as a schedule III controlled substance. This means androstenediol is available only as a prescription medicine, and physicians have to follow strict rules when prescribing it. It is banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA) for use by athletes.
Androstenediol is used to increase testosterone levels in the body to improve athletic performance, to enhance response to sexual stimuli in healthy people, to improve sexual problems that prevent satisfaction during sexual activity, and other conditions, but there is no good scientific evidence to support these uses. Androstendiol might also be unsafe.
Safety Safety definitions
When taken by mouth: Androstenediol is POSSIBLY UNSAFE for most people when taken by mouth. There is some concern that products can vary from what is listed on the label. Women who take androstenediol might develop some male characteristics including deepening of the voice, facial hair growth, acne, abnormal menstrual periods, male-pattern baldness, thickening of the skin, and depression.
Heart disease: There is some concern that androstenediol might increase the risk of coronary heart disease.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Androstenediol can increase levels of hormones such estrone, estradiol, and testosterone. If you have any condition that might be made worse by exposure to these hormones, don't use androstenediol.
Prostate cancer and benign prostatic hypertrophy (BPH): Androstenediol can increase testosterone levels. There is also developing evidence that androstenediol might help prostate cancer cells grow. If you have a prostate condition, don't use androstenediol.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if androstenediol is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Heart disease: There is some concern that androstenediol might increase the risk of coronary heart disease.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Androstenediol can increase levels of hormones such estrone, estradiol, and testosterone. If you have any condition that might be made worse by exposure to these hormones, don't use androstenediol.
Prostate cancer and benign prostatic hypertrophy (BPH): Androstenediol can increase testosterone levels. There is also developing evidence that androstenediol might help prostate cancer cells grow. If you have a prostate condition, don't use androstenediol.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly ineffective Effectiveness definitions
- Athletic performance. Androstenediol does not seem to help increase muscle size or strength when taken by mouth for 12 weeks in connection with resistance training.
Insufficient evidence Effectiveness definitions
- Increasing energy.
- Improving body recovery and growth from exercise.
- Heightening sexual arousal and performance.
- Increasing a sense of well-being.
- Other conditions.
Dosing & administration
The appropriate dose of androstenediol depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for androstenediol. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Interactions with pharmaceuticals
Estrogens
Interaction Rating=Moderate Be cautious with this combination.
Androstenediol seems to increase estrogen levels in the body. Taking androstenediol along with estrogen pills might cause too much estrogen in the body.
Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Testosterone
Interaction Rating=Moderate Be cautious with this combination.
The body changes androstenediol into testosterone. Taking androstenediol with a testosterone pill might cause there to be too much testosterone in the body. This might increase the chance of testosterone side effects.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Action
Androstenediol is a steroid hormone used by the body to make testosterone and estrogen.
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This monograph was last reviewed on 31/01/2024 11:00:00 and last updated on 05/08/2020 01:50:53. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
