Androstenetrione
Alternate names: 6-OXO, ADT, Androstenetriona, Androsténétrione
Background
Androstenetrione is a steroid. Despite serious safety concerns, it is used for improving athletic performance.
Androstenetrione is promoted as an alternative to “prohormones” such as androstenedione. Marketers claim that androstenetrione increases the body's natural testosterone levels and therefore is free from the negative side effects of prohormones. There is no reliable evidence to back these claims.
Androstenetrione is promoted as an alternative to “prohormones” such as androstenedione. Marketers claim that androstenetrione increases the body's natural testosterone levels and therefore is free from the negative side effects of prohormones. There is no reliable evidence to back these claims.
Safety Safety definitions
Androstenetrione might be UNSAFE for anyone. If it actually increases testosterone levels in the body, the extra testosterone could cause serious side effects including liver problems, heart problems, and cancer. Avoid using androstenetrione.
Pregnancy and breast-feeding: Not enough is known about the use of androstenetrione during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Prostate cancer and other hormone-sensitive cancers: Androstenetrione might increase testosterone levels. Men with hormone-sensitive conditions such as prostate cancer should avoid using androstenetrione.
Liver disease: Androstenetrione might increase testosterone levels. Increased testosterone is associated with liver problems. If you have liver disease, don’t take androstenetrione. If you have taken androstenetrione, it would be a good idea to have liver function tests (LFTs) done.
Special Precautions & Warnings:
It might be UNSAFE for anyone to use androstenetrione, but people with the following conditions have extra reasons to avoid use.Pregnancy and breast-feeding: Not enough is known about the use of androstenetrione during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Prostate cancer and other hormone-sensitive cancers: Androstenetrione might increase testosterone levels. Men with hormone-sensitive conditions such as prostate cancer should avoid using androstenetrione.
Liver disease: Androstenetrione might increase testosterone levels. Increased testosterone is associated with liver problems. If you have liver disease, don’t take androstenetrione. If you have taken androstenetrione, it would be a good idea to have liver function tests (LFTs) done.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Insufficient evidence Effectiveness definitions
- Improving athletic performance.
- Other conditions.
Dosing & administration
The appropriate dose of androstenetrione depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for androstenetrione. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Interactions with pharmaceuticals
It is not known if Androstenetrione interacts with any medicines. Before taking Androstenetrione, talk with your healthcare professional if you take any medications.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Action
The body converts some of the male hormone testosterone to the female hormone estrogen. Androstenetrione blocks this conversion. Some people suggest that the body makes up for the falling estrogen level by making more testosterone. They further suggest that the higher levels of testosterone will improve athletic performance. Some people who sell androstenetrione say that it increases total testosterone by 188% and free testosterone by 226% over 3 weeks of use. But there is no scientifically reliable research in people that supports these claims.
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This monograph was last reviewed on 31/01/2024 11:00:00 and last updated on 26/12/2012 18:00:32. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
