Background

Bitter melon (Momordica charantia) is a vine originally from India and other Asian countries. It has been traditionally used to treat diabetes.

Bitter melon contains a chemical that acts like insulin to help reduce blood sugar levels.

People commonly use bitter melon for diabetes, osteoarthritis, athletic performance, and many other conditions, but there is no good scientific evidence to support these uses.

Bitter melon is sometimes called bitter gourd. Don't confuse this with Ivy gourd, which is a different plant.

Safety Safety definitions

When taken by mouth: Bitter melon is possibly safe when used for up to 4 months. Bitter melon might cause upset stomach in some people. There isn't enough reliable information to know if bitter melon is safe to use long-term.

When applied to the skin: There isn't enough reliable information to know if bitter melon is safe. It might cause a rash.

Special Precautions & Warnings:

Pregnancy: Bitter melon is possibly unsafe when taken by mouth during pregnancy. Certain chemicals in bitter melon might harm the pregnancy.

Breast-feeding: There isn't enough reliable information to know if bitter melon is safe to use when breast-feeding. Stay on the safe side and avoid use.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency: Bitter melon seeds might cause severe anemia in people who have G6PD deficiency. Until more is known, avoid bitter melon seeds if you have G6PD deficiency.

Surgery: Bitter melon might interfere with blood sugar control during and after surgery. Stop using bitter melon at least 2 weeks before a scheduled surgery.

Effectiveness

Dosing & administration

Bitter melon has most often been used by adults in doses of 0.5-12 grams by mouth daily for up to 16 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Interactions with pharmaceuticals

Medications for diabetes (Antidiabetes drugs)

Interaction Rating=Moderate Be cautious with this combination.

Bitter melon might lower blood sugar levels. Taking bitter melon along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Medications moved by pumps in cells (P-Glycoprotein Substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are moved in and out of cells by pumps. Bitter melon might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.

Pazopanib (Votrient)

Interaction Rating=Moderate Be cautious with this combination.

Bitter melon might increase how much pazopanib stays in the body. In some cases, this might increase the effects and side effects of pazopanib.

Interactions with herbs & supplements

Herbs and supplements that might lower blood sugar: Bitter melon might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, cassia cinnamon, chromium, and prickly pear cactus.

Interactions with foods

There are no known interactions with foods.