Caffeic acid
Alternate names: Acide Caféique, Ácido Cafeico
Background
Caffeic acid is a type of phenolic acid found in many plants and foods, such as apples and red wine. Coffee is the main source of caffeic acid in the diet.
Caffeic acid might have antioxidant and anti-inflammatory effects. It might also have effects on the immune system.
People use caffeic acid for athletic performance, obesity, and other purposes, but there is no good scientific evidence to support these uses.
Caffeic acid might have antioxidant and anti-inflammatory effects. It might also have effects on the immune system.
People use caffeic acid for athletic performance, obesity, and other purposes, but there is no good scientific evidence to support these uses.
Safety Safety definitions
When taken by mouth: Caffeic acid is commonly consumed in foods. But there isn't enough reliable information to know if caffeic acid is safe to use as medicine or what the side effects might be.
Insomnia. Caffeic acid might have a mild stimulating effect that could make insomnia worse. But this effect is much less than with caffeine.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Caffeic acid is commonly consumed in foods. But there isn't enough reliable information to know if caffeic acid is safe to use as medicine when pregnant or breast-feeding. Stay on the safe side and avoid use.Insomnia. Caffeic acid might have a mild stimulating effect that could make insomnia worse. But this effect is much less than with caffeine.
Effectiveness
Effective Effectiveness definitions
There is interest in using caffeic acid for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Dosing & administration
Caffeic acid is found in many plants and foods. Coffee is the biggest source of caffeic acid in the diet, but it's also found in red wine, berries, apples, olives, artichokes, and pears. As medicine, there isn't enough reliable information to know what an appropriate dose of caffeic acid might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
Interactions with pharmaceuticals
Levodopa
Interaction Rating=Minor Be watchful with this combination.
Caffeic acid might change the way the body breaks down and gets rid of levodopa. But it's not clear if this is a big concern.
Medications moved by pumps in cells (Organic anion transporter 1 (OAT1) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are moved in and out of cells by pumps. Caffeic acid might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Medications moved by pumps in cells (Organic anion transporter 3 (OAT3) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are moved in and out of cells by pumps. Caffeic acid might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
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This monograph was last reviewed on 16/01/2021 00:45:44 and last updated on 05/08/2022 08:04:33. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
