Background

Cherokee rosehip contains vitamin C (approximately 1.5%) (11).

People use this for...

Safety Safety definitions

Possibly Safe ...when used orally and appropriately. It contains vitamin C as a major constituent (11).

Possibly Unsafe ...when used orally in large amounts. Hyperoxaluria, hyperuricosuria, hematuria, and crystalluria can occur in some people taking 1 gram of vitamin C (67 grams of Cherokee rosehip) or more per day (3042). Prolonged use of large amounts of vitamin C can increase its metabolism, and scurvy might occur when intake is reduced (15).

Possibly Unsafe ...when used orally in large doses because it is associated with newborn scurvy (15). There is insufficient reliable information available about the safety of using smaller amounts of Cherokee rosehip.

Lactation: Insufficient reliable information available.

Effectiveness Effectiveness definitions

There is insufficient reliable information available about the effectiveness of Cherokee rosehip.

Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Dosing & administration

Adverse effects

General: Orally, the vitamin C in Cherokee rosehip may cause nausea, abdominal cramps, fatigue, insomnia, and sleepiness. Doses greater than 1 gram may cause diarrhea (15).

Interactions with pharmaceuticals

ESTROGENSInteraction Rating: Moderate Be cautious with this combination.Severity: Moderate Occurrence: Possible Level of evidence: DTheoretically, the vitamin C in large amounts of Cherokee rosehip might increase absorption and effects of estrogen (129,130).

FLUPHENAZINE (Prolixin)Interaction Rating: Moderate Be cautious with this combination.Severity: Moderate Occurrence: Probable Level of evidence: DConcomitant use with Cherokee rosehip decreases blood levels due to vitamin C content (15).

ALUMINUMInteraction Rating: Moderate Be cautious with this combination.Severity: Mild Occurrence: Probable Level of evidence: DConcomitant use interacts with the vitamin C in Cherokee rose hip and can increase aluminum absorption, but the clinical significance of this is unknown (3046). Administer Cherokee rose hip with vitamin C two hours before or four hours after antacids (3046).

ASPIRINInteraction Rating: Moderate Be cautious with this combination.Severity: Moderate Occurrence: Possible Level of evidence: DTheoretically, the vitamin C in large amounts of Cherokee rosehip might decrease excretion of aspirin (15).

WARFARIN (Coumadin)Interaction Rating: Moderate Be cautious with this combination.Severity: High Occurrence: Possible Level of evidence: DTheoretically, the vitamin C in large amounts of Cherokee rosehip might reduce anticoagulant activity (506).

CHOLINE MAGNESIUM TRISALICYLATE (Trilisate)Interaction Rating: Minor Be watchful with this combination.Severity: Moderate Occurrence: Unlikely Level of evidence: DThe vitamin C in Cherokee rose hip can increase urinary excretion of ascorbic acid and decrease excretion of salicylates such as choline magnesium trisalicylate. But this may not have a clinically significant effect on salicylate plasma levels (3046).

Interactions with herbs & supplements

Due to the vitamin C content, concomitant use of Cherokee rosehip with other products containing vitamin C increases total dose of vitamin C and may increase risk of adverse effects.

Interactions with foods

Theoretically, the vitamin C in Cherokee rosehip might increase GI absorption of food iron (ferric) but not supplement iron (ferrous) (15).

Interactions with lab tests

Theoretically, large amounts of Cherokee rosehip may cause a false-negative result if ingested 48-72 hours before amine-dependent tests due to vitamin C content (506).

Theoretically, large amounts of Cherokee rosehip (containing greater than 500 mg vitamin C) may cause false decreases with glucose oxidase tests (e.g. Clinistix) and may cause false increases with cupric sulfate tests (e.g. Clinitest) (15).

Interactions with diseases

DIABETES: Large amounts may affect blood sugar control because of the vitamin C content (15).

GOUT: Theoretically, the vitamin C in large amounts of Cherokee rosehip might increase uric acid levels (15).

KIDNEY STONES (Nephrolithiasis): Theoretically, the vitamin C in large amounts of Cherokee rosehip might cause precipitation of urate, cystine, or oxalate stones (15).

Mechanism of action

Cherokee rosehip contains vitamin C (approximately 1.5%) (11). An antidiarrheal effect occurs in humans (11).

References