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Dhea

Scientific names: Dehydroepiandrosterone

Alternate names: 3b-Hydroxy-Androst-5-Ene-17-One, 3BetaHydroxy-Androst-5-Ene-17-One, Androstenolone, Déhydroépiandrostérone, DHEA-S, GL701, Prasterone

Actions: Adrenal insufficiency, Antiaging, Antiarthritic, Antiasthma, Antidiabetic, Antioxidant, Antiviral, Bone, Cardiovascular, Cognitive, Fertility, Hepatic, Hormonal, Immune, Inflammatory, Lipid, Metabolic, Musculoskeletal, Neuroprotective, Nociceptive, Ocular, Opioid receptor, Pulmonary, Radiation, Sexuality, Skin, Stress, Thyroid, Vaginal, Vascular

Scientific names: Dehydroepiandrosterone

Alternate names: 3b-Hydroxy-Androst-5-Ene-17-One, 3BetaHydroxy-Androst-5-Ene-17-One, Androstenolone, Déhydroépiandrostérone, DHEA-S, GL701, Prasterone

Background

Dehydroepiandrosterone (DHEA) is a hormone that is turned into male and female sex hormones in the body. Prescription DHEA is used to treat thin vaginal tissue.

DHEA is made by the adrenal glands and by the liver. DHEA levels seem to go down as people get older. DHEA levels seem to be lower in people with depression and after menopause.

People commonly use prescription DHEA for vaginal tissue thinning. DHEA supplements are used for aging skin, depression, infertility, muscle strength, heart disease, erectile dysfunction (ED), and many other conditions, but there is no good scientific evidence to support many of these other uses.

DHEA is banned by the National Collegiate Athletic Association (NCAA), the International Olympic Committee, and the World Anti-Doping Agency (WADA). Don't confuse DHEA with 7-alpha-hydroxy-DHEA, 7-beta-hydroxy-DHEA, and 7-keto-DHEA. These are all different forms of DHEA but are not the same as DHEA.

Safety Safety definitions

When taken by mouth: DHEA is possibly safe when used short-term. DHEA has been used safely for up to 2 years, usually in doses of 50 mg daily. DHEA side effects are usually mild and might include acne and upset stomach.

DHEA is possibly unsafe when used in high doses or long-term. Do not use DHEA in doses higher than 50-100 mg daily or for a long period of time. Using higher doses or using it long-term can increase the risk of serious side effects including cancer.

When applied to the skin: DHEA is possibly safe when used appropriately. DHEA cream has been used safely for up to 1 year.

When applied into the vagina: DHEA is possibly safe when used appropriately. DHEA vaginal inserts have been safely used for up to 3 months.

Special Precautions & Warnings:

Pregnancy and breast-feeding: DHEA is possibly unsafe when taken during pregnancy or breast-feeding. It can cause higher than normal levels of a male hormone called androgen. This might be harmful to the baby. Do not use DHEA if you are pregnant or breast-feeding.

Diabetes: DHEA can affect how insulin works in the body. If you have diabetes, monitor your blood sugar carefully if you are taking DHEA.

Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: DHEA is a hormone that can affect how estrogen works in the body. If you have any condition that might be made worse by estrogen, do not use DHEA.

High cholesterol: DHEA might lower high-density lipoprotein (HDL or "good") cholesterol, especially in females. If you have high cholesterol or heart disease, talk with your healthcare provider before taking DHEA.

Liver problems: DHEA might make liver problems worse. Do not use DHEA if you have liver problems.

Depression and mood disorders: DHEA might cause excitability, impulsiveness, and irritability in people with mood disorders. If you have a mood disorder, talk to your healthcare provider before taking DHEA.

Polycystic ovary syndrome (PCOS): Taking DHEA might make this condition worse. Don't use DHEA if you have PCOS.

Effectiveness

NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Likely effective Effectiveness definitions

Thinning of vaginal tissue (vaginal atrophy). Using vaginal inserts containing DHEA can reduce pain during sex by up to 15% after menopause. A prescription DHEA product is available for this condition.

Possibly effective Effectiveness definitions

Aging skin. Taking DHEA by mouth or applying it to the skin might improve skin appearance after menopause and in people over the age of 60 years.
Depression. Taking 30-500 mg of DHEA by mouth daily seems to improve symptoms of depression. Lower doses don't seem to help.
Inability to become pregnant within a year of trying to conceive (infertility). Taking DHEA by mouth before in-vitro fertilization (IVF) might improve the chances of pregnancy and having a baby. But it's not clear if taking DHEA helps prevent miscarriage after IVF.

Likely ineffective Effectiveness definitions

Memory and thinking skills (cognitive function). Taking DHEA by mouth does not seem to improve mental function or decrease mental decline in healthy older people, people with HIV, or in healthy young adults.
An autoimmune disorder in which the glands that produce tears and saliva are damaged (Sjogren syndrome). Taking DHEA by mouth does not improve symptoms of this condition.

There is interest in using DHEA for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Possibly ineffective Effectiveness definitions

Aging. Taking DHEA by mouth daily for up to 2 years doesn't seem to improve body shape, bone strength, muscle strength, or quality of life in people older than 60 who have low DHEA levels.
Muscle strength. Taking DHEA by mouth doesn't improve muscle strength in adults.
Physical performance in elderly adults. Taking DHEA by mouth doesn't improve physical performance in older adults.

Dosing & administration

DHEA has most often been used by adults at a dose of 50 mg by mouth daily for up to 1 year. DHEA is also available in topical creams and vaginal products. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

Interactions with pharmaceuticals

Estrogens

Interaction Rating=Minor Be watchful with this combination.

DHEA might increase estrogen levels in the body. Taking DHEA along with estrogen might cause too much estrogen in the body.