Glutathione
Scientific names: N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine
Alternate names: Gamma-Glutamylcysteinylglycine, Gamma-L-Glutamyl-L-Cysteinylglycine, Gamma-L-Glutamyl-L-Cystéinylglycine, Glutathion, Glutatión, L-Gamma-Glutamyl-L-Cysteinyl-Glycine, L-Gamma-Glutamyl-L-Cystéinyl-Glycine, L-Glutathion, L-Glutathione, GSH, Reduced Glutathione
Actions: Anti-cancer, Antioxidant, Neuroprotective, Anti-viral, Hepatic
Background
Glutathione is a substance made from the amino acids glycine, cysteine, and glutamic acid. It is produced by the liver and involved in many body processes.
Glutathione is involved in tissue building and repair, making chemicals and proteins needed in the body, and in immune system function.
People take glutathione for aging, alcohol use disorder, liver disease, heart disease, and many other conditions, but there is no good scientific evidence to support these uses.
Glutathione is involved in tissue building and repair, making chemicals and proteins needed in the body, and in immune system function.
People take glutathione for aging, alcohol use disorder, liver disease, heart disease, and many other conditions, but there is no good scientific evidence to support these uses.
Safety Safety definitions
When taken by mouth: Glutathione is possibly safe when used in doses up to 500 mg daily for up to 2 months. There isn't a lot of information available about its possible side effects.
When inhaled: Glutathione is possibly safe. There isn't a lot of information available about its possible side effects.
When applied to the skin: There isn't enough reliable information to know if glutathione is safe. It might cause rash when applied to the skin.
Asthma: Do not inhale glutathione if you have asthma. It can increase some asthma symptoms.
When inhaled: Glutathione is possibly safe. There isn't a lot of information available about its possible side effects.
When applied to the skin: There isn't enough reliable information to know if glutathione is safe. It might cause rash when applied to the skin.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if glutathione is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Asthma: Do not inhale glutathione if you have asthma. It can increase some asthma symptoms.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Nerve damage caused by the drug cisplatin. Taking glutathione by IV seems to help prevent nerve damage and other toxicities from the cancer drug cisplatin. IV products can only be given by a healthcare provider.
Dosing & administration
There isn't enough reliable information to know what an appropriate dose of glutathione might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
Interactions with pharmaceuticals
It is not known if Glutathione interacts with any medicines. Before taking Glutathione, talk with your healthcare professional if you take any medications.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
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Practitioner product
Practitioner product
Per 5 g (Orange Mango):
Practitioner product
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Per capsule:
- Reduced glutathione 50 mg
- Reynoutria japonica ext. 225 mg
- Zinc citrate dihydrate 15.6 mg equiv. zinc 5 mg
- Total Vitamin C 152.9 mg
- Calcium ascorbate dihydrate (Vitamin C) 125.5 mg equiv. ascorbic acid 103.7 mg
- Ascorbyl palmitate (Vitamin C) 45 mg equiv. ascorbic acid 19.1 mg
- Ascorbic acid (Vitamin C) 30.1 mg
- Beta-carotene carotenoids (Vitamin A) 2.7 mg
- Vitis vinifera ext. 60.4 mg
- Silybum marianum ext. 18.8 mg
- Vaccinium myrtillus ext. 1 mg
- Retinol acetate 300 μg equiv. vitamin A 261 μg RE
- Riboflavin (Vitamin B2) 5 mg
- Nicotinamide (Vitamin B3) 20 mg
- R,S-alpha lipoic acid 20 mg
- Selenomethionine 248.6 μg equiv. selenium 100 μg
- Lycopersicon esculentum (Tomato) 8.3 mg equiv. lycopene 500 μg equiv. fresh fruit 2.9 g
- Palm tocotrienols complex (Vitamin E) 20 mg equiv. mixed tocopherols 900 μg
Practitioner product
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Per tablet:
- Reduced glutathione 25 mg
- Potassium iodide 190 μg equiv. iodine 145 μg
- Selenomethionine 186 μg equiv. selenium 75 μg
- L-tyrosine 500 mg
- Zinc amino acid chelate 50 mg equiv. zinc 10 mg
- Retinol acetate 431.2 μg equiv. vitamin A 375 μgRE
- Ascorbic acid (Vitamin C) 50 mg
- d-alpha-Tocopheryl acid succinate 10.3 mg equiv. vitamin E 12.5 IU
- Bupleurum falcatum ext. 50 mg
- Schisandra chinensis ext. 187.5 mg
- Cholecalciferol 7.5 μg equiv. vitamin D3 300 IU
Practitioner product
Per tablet:
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Per 5 g (Pear):
Practitioner product
Practitioner product
Per tablet:
- Glutathione 20 mg
- L-glutamine 100 mg
- Ascorbic acid (Vitamin C) 20 mg
- Selenomethionine 124 μg equiv. selenium 50 μg
- Zinc amino acid chelate 25 mg equiv. zinc 5 mg
- Silybum marianum ext. 85.7 mg
- Brassica oleracea var. italica ext. 75 mg
- Cysteine hydrochloride 29 mg equiv. cysteine 20 mg
- L-glycine 150 mg
- Taurine 200 mg
- L-methionine 100 mg
- Choline bitartrate 200 mg
- Inositol 100 mg
- L-ornithine monohydrochloride 10 mg equiv. ornithine 7.84 mg
- Citrus bioflavonoids extract 30 mg
- Molybdenum trioxide 60 μg equiv. molybdenum 40 μg
- Copper gluconate 42.86 μg equiv. copper 6 μg
- Pyridoxal 5-phosphate (P5P) 7.84 mg equiv. pyridoxine 5 mg
- Calcium folinate (Activated folate) 69.44 μg equiv. folinic acid 50 μg
- Cyanocobalamin (Vitamin B12) 50 μg
- Manganese amino acid chelate 250 μg equiv. manganese 25 μg
Practitioner product
Per 5 g (Citrus):
Practitioner product
Per tablet:
- Glutathione 10 mg
- Total Ascorbic acid 1 g
- Calcium ascorbate dihydrate (Vitamin C) 726 mg equiv. ascorbic acid 600 mg
- Sodium ascorbate (Vitamin C) 452 mg equiv. ascorbic acid 400 mg
- Rutin (Rutoside) 25 mg
- Citrus bioflavonoids extract 25 mg
- R-alpha lipoic acid 20 mg
- Selenomethionine 38 μg equiv. selenium 15 μg
- Nicotinamide (Vitamin B3) 5 mg
- Pyridoxal 5-phosphate (P5P) 2.19 mg equiv. pyridoxine 1.5 mg
- Palm tocotrienols complex (Vitamin E) 2 mg
Practitioner product
Practitioner product
Per 3.5 g (Pineapple):
- Glutathione 250 mg
- Allium sativum ext. 400 mg
- Yeast 116.65 mg equiv. selenium 140 µg
- Alpha lipoic acid 400 mg
- Ascorbic acid (Vitamin C) 1 g
- Levomefolate glucosamine (Activated folate) 712 µg equiv. levomefolic acid 400 µg
- Zinc citrate dihydrate 62.60 mg equiv. zinc 20 mg
- Manganese sulphate monohydrate 2.46 mg equiv. manganese 800 µg
Practitioner product
Per tablet:
- Glutathione 25 mg
- Beta-carotene carotenoids (Vitamin A) 600 μg
- Cholecalciferol 1.25 μg equiv. vitamin D3 50 IU
- d-alpha-Tocopheryl acid succinate (Vitamin E) 4.13 mg
- Co-methylcobalamin (Vitamin B12) 20 μg
- Zinc citrate dihydrate 11.74 mg equiv. zinc 3.75 mg
- Calcium ascorbate dihydrate (Vitamin C) 30.26 mg equiv. ascorbic acid 25 mg
- Magnesium ascorbate (Vitamin C) 20.32 mg equiv. ascorbic acid 15.24 mg equiv. magnesium 2.134 mg
- Vaccinium macrocarpon powder 5 mg
- Camellia sinensis ext. 5 mg
- Schizandra chinensis ext. 5 mg
- Arthrospira platensis (Spirulina) 5 mg
- Euterpe oleracea (berry) ext. (Acai) 5 mg
- Chlorella vulgaris powder 5 mg
- Zingiber officinale ext. 5 mg
- Laminaria digitara (Kelp) 5 mg
- Phyllanthus emblica ext. 9.52 mg
- Thiamine hydrochloride (Vitamin B1) 1.27 mg equiv. thiamine 1 mg
- Riboflavin 5-phosphate sodium (Activated B2) 1.37 mg equiv. riboflavin 1 mg
- Nicotinamide (Vitamin B3) 5 mg
- Calcium pantothenate (Vitamin B5) 10.87 mg equiv. pantothenic acid 10 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 2.19 mg equiv. pyridoxine 1.5 mg
- Calcified lithothamnion (Red algae) 43.18 mg equiv. magnesium 1 mg
- Copper sulfate 3.93 mg
- Silicon dioxide 53.53 mg equiv. silicon 25 mg
- Manganese gluconate 3.24 mg equiv. manganese 400 μg
- Selenomethionine 46.57 μg equiv. selenium 18.75 μg
- Lysine hydrochloride 3.12 mg equiv. l-lysine 2.5 mg
- Lycopene 250 μg
- Choline bitartrate 62.66 mg equiv. choline 25 mg
- Inositol 10 mg
- Biotin 1.5 mg
- Aspalathus linearis 50 mg
- Equisetum arvense ext. 2.5 mg
- Citrus sinensis ext. 5 mg
- Magnesium citrate 30.94 mg equiv. magnesium 5 mg
- Magnesium glycinate 30.97 mg equiv. magnesium 4.37 mg
- Curcumin (Turmeric) 1.5 mg
- Ultra fruit blend 25 mg
- Cruciferous vegetable blend 25 mg
- Live vegetable blend 22.5 mg
- Multi herb blend 10 mg
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This monograph was last reviewed on 03/10/2024 10:00:00 and last updated on 26/03/2022 08:59:11. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
