Glycine
Scientific names: Aminoacetic Acid
Alternate names: Acide Aminoacétique, Acide Amino-Acétique, Athenon, Free Base Glycine, G Salt, Glicina, Glycine de Base Libre, Glycocoll, Glycosthene, Iconyl, L-Glycine, Monazol
Actions: Anti-cancer, Antioxidant, Central nervous system (CNS), Cyclosporine-protective, Hepatoprotective, Sleep
Background
Glycine is an amino acid. The body can make glycine on its own, but it is also consumed in the diet. Sources include meat, fish, dairy, and legumes.
Glycine is a building block for making proteins in the body. Glycine is also involved in transmitting chemical signals in the brain, so there's interest in using it for schizophrenia and improving memory. A typical diet contains about 2 grams of glycine daily.
People use glycine for schizophrenia, stroke, memory and thinking skills, insomnia, and many other purposes, but there is no good scientific evidence to support most of these uses.
Glycine is a building block for making proteins in the body. Glycine is also involved in transmitting chemical signals in the brain, so there's interest in using it for schizophrenia and improving memory. A typical diet contains about 2 grams of glycine daily.
People use glycine for schizophrenia, stroke, memory and thinking skills, insomnia, and many other purposes, but there is no good scientific evidence to support most of these uses.
Safety Safety definitions
When taken by mouth: Glycine is possibly safe for most people when taken in doses up to 6 grams daily for 4 weeks. It's usually well-tolerated. Some people might have mild side effects such as stomach upset.
When applied to the skin: There isn't enough reliable information to know if glycine is safe or what the side effects might be.
When applied to the skin: There isn't enough reliable information to know if glycine is safe or what the side effects might be.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if glycine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Schizophrenia. Taking glycine by mouth along with some antipsychotic drugs seems to reduce certain symptoms, called negative symptoms, in some people who don't respond to treatment with conventional drugs. But it's not clear if glycine is helpful in people who are taking newer medications, such as clozapine.
Dosing & administration
Glycine has most often been used by adults in doses of 3 grams by mouth daily for up to 24 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Interactions with pharmaceuticals
Clozapine (Clozaril)
Interaction Rating=Moderate Be cautious with this combination.
Clozapine is used to help treat schizophrenia. Taking glycine along with clozapine might decrease the effects of clozapine. It is not clear why this interaction occurs. Do not take glycine if you are taking clozapine.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
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Per 7 g (Lemon Lemonade):
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Per 8.3 g (Berry & Ginger):
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Per 5 g (Lemon Lime):
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Per 6 g:
- Glycine 2 g
- Acetyl levocarnitine hydrochloride (Acetyl-L-carnitine) 250 mg
- Inositol 500 mg
- Choline bitartrate 350 mg equiv. choline 144 mg
- Pinus radiata ext. 50 mg
- Taurine 500 mg
- Calcium citrate 415 mg equiv. calcium 100 mg
- Potassium citrate 207 mg equiv. potassium 75 mg
- Magnesium citrate 842 mg equiv. magnesium 130 mg
- Zinc citrate dihydrate 31 mg equiv. zinc 10 mg
- Molybdenum trioxide 33 μg equiv. molybdenum 22.2 μg
- Selenomethionine 74.4 μg equiv. selenium 30 μg
- Pyridoxal 5-phosphate monohydrate (P5P) 15.7 mg equiv. pyridoxine 10 mg
- Nicotinamide (Vitamin B3) 15 mg
- Menaquinone 7 (Vitamin K2) 34.8 μg
- Hydroxocobalamin (Vitamin B12) 200 μg
- Calcium pantothenate (Vitamin B5) 20 mg equiv. pantothenic acid 18.3 mg
- Cholecalciferol (Vitamin D3) 24.6 μg equiv. vitamin D 1000 IU
- Calcium folinate (Activated folate) 217 μg equiv. folinic acid 200 μg
- Retinol acetate (Vitamin A) 461 μg equiv. vitamin A 400 μgRE equiv. vitamin A 1335 IU
- Riboflavin 5-phosphate sodium (Activated B2) 6.54 mg equiv. riboflavin 4.98 mg
- Lecithin 100 mg equiv. phosphatidylcholine 20 mg
- Punica granatum ext. 8.04 mg
- Vaccinium myrtillus ext. 2.5 mg
- Thiamine hydrochloride (Vitamin B1) 12.7 mg equiv. thiamine 10 mg
Practitioner product
Per 5 g (Berry and Peach):
- L-glycine 2 g
- Cholecalciferol 10 μg equiv. vitamin D3 400 IU
- Retinyl acetate 472 μg equiv. vitamin A 400 μg
- Zinc citrate dihydrate 18.65 mg equiv. zinc 6 mg
- Palm tocotrienols complex (Vitamin E) 2.5 mg
- Hydroxocobalamin (Vitamin B12) 15 μg
- Calcium ascorbate dihydrate (Vitamin C) 60.5 mg equiv. ascorbic acid 50 mg
- Calcium citrate 1.04 g equiv. calcium 250 mg
- Magnesium citrate 802.5 mg equiv. magnesium 130 mg
- Menaquinone 7 (Vitamin K2) 5 μg
- Phytomenadione (Vitamin K1) 30 μg
- Potassium iodide 117.7 μg equiv. iodine 90 μg
- Iron bisglycinate 17.78 mg equiv. iron 4 mg
- Riboflavin 5-phosphate sodium (Activated B2) 5 mg
- Nicotinamide (Vitamin B3) 15 mg
- Calcium pantothenate (Vitamin B5) 16.4 mg equiv. pantothenic acid 15 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 1.55 mg equiv. pyridoxine 1 mg
- Biotin 25 μg
- Chromium nicotinate 120.7 μg equiv. chromium 15 μg
- Manganese amino acid chelate 2500 μg equiv. manganese 250 μg
- Molybdenum trioxide 33.75 μg equiv. molybdenum 22.5 μg
- Calcium hydrogen phosphate dihydrate 54.58 mg equiv. calcium 12.7 mg
- Lysine hydrochloride 15 mg equiv. lysine 12 mg
- Choline bitartrate 150 mg
- Selenomethionine 75 μg equiv. selenium 30 μg
- Thiamine hydrochloride (Vitamin B1) 5 mg equiv. thiamine 3.9 mg
- Pyridoxine hydrochloride (Vitamin B6) 4.5 mg equiv. pyridoxine 3.7 mg
- Calcium folinate (Activated folate) 215 μg equiv. folinic acid 200 μg
- Potassium citrate 27.68 mg equiv. potassium 10 mg
- Total Ascorbic acid 100 mg
Practitioner product
Per 13 g (Orange):
- Glycine 2 g
- Magnesium citrate 1.94 g equiv. magnesium 300 mg
- Potassium citrate 553 mg equiv. potassium 200 mg
- Calcium citrate 1.82 g equiv. calcium 400 mg
- Zinc citrate dihydrate 77.9 mg equiv. zinc 25 mg
- Selenomethionine 78 µg equiv. selenium 31.5 µg
- Taurine 3 g
- Calcium ascorbate dihydrate (Vitamin C) 1.22 g equiv. ascorbic acid 1 g equiv. calcium 114 mg
- Thiamine hydrochloride (Vitamin B1) 25.4 mg equiv. thiamine 20 mg
- Riboflavin 5-phosphate sodium (Activated B2) 13.2 mg equiv. riboflavin 10 mg
- Nicotinamide (Vitamin B3) 25 mg
- Calcium pantothenate (Vitamin B5) 32.8 mg equiv. pantothenic acid 30 mg equiv. calcium 2.73 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 78.4 mg equiv. pyridoxine 50 mg
- Biotin 500 µg
- Molybdenum trioxide 90 µg equiv. molybdenum 60 µg
- Chromium chloride hexahydrate 507 µg equiv. chromium 100 µg
- Menaquinone 7 (Vitamin K2) 45 µg
Practitioner product
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Per 7.2 g (Fruit Punch):
- L-glycine 1.75 g
- Sodium chondroitin sulphate (bovine) 120 mg equiv. chondroitin sulphate 108 mg
- L-leucine 240 mg
- L-valine 240 mg
- Glucosamine hydrochloride 600 mg equiv. glucosamine 498 mg
- Glucosamine sulphate potassium chloride 600 mg equiv. potassium 155 mg equiv. glucosamine 354.7 mg
- Lysine hydrochloride 720 mg
- Creatine monohydrate 600 mg
- Ascorbic acid (Vitamin C) 600 mg
- Citrus bioflavonoids extract 396 mg
- Calcium pantothenate (Vitamin B5) 36 mg equiv. pantothenic acid 33 mg
- Zinc amino acid chelate 30 mg equiv. zinc 6 mg
- Copper gluconate 4.6 mg equiv. copper 600 µg
- Selenomethionine 130 µg equiv. selenium 52.2 µg
- Borax 19.4 mg equiv. boron 2.23 mg
Practitioner product
Per 22 g (Vanilla):
- L-glycine 1.5 g
- Pisum sativum ext. 3.32 g
- Thiamine hydrochloride (Vitamin B1) 21.6 mg equiv. thiamine 17 mg
- Nicotinamide (Vitamin B3) 50 mg
- Calcium pantothenate (Vitamin B5) 54.6 mg equiv. pantothenic acid 50 mg
- Hydroxocobalamin (Vitamin B12) 200 μg
- Ascorbic acid (Vitamin C) 250 mg
- L-glutamine 1.5 g
- Larix occidentalis (arabinogalactan) (Larch) 1 g
- Riboflavin 5-phosphate sodium (Activated B2) 6.58 mg equiv. riboflavin 5 mg
- Cholecalciferol 10 μg equiv. vitamin D3 400 IU
- Taurine 350 mg
- Molybdenum trioxide 77 μg equiv. molybdenum 50 μg
- Potassium iodide 66 μg equiv. iodine 50 μg
- Chromium nicotinate 193.6 μg equiv. chromium 24 μg
- Selenomethionine 125.4 μg equiv. selenium 50 μg
- Manganese gluconate 8.1 mg equiv. manganese 1 mg
- Zinc citrate dihydrate 46.6 mg equiv. zinc 15 mg
- Magnesium citrate 330 mg equiv. magnesium 50 mg
- Biotin 50 μg
- Levomefolate glucosamine (Activated folate) 360 μg equiv. levomefolic acid 200 μg
- Pyridoxal 5-phosphate (P5P) 15.7 mg equiv. pyridoxine 10 mg
- Choline bitartrate 30 mg
- Silybum marianum ext. 150 mg
- Camellia sinensis powder 250 mg
- Zingiber officinale ext. 135 mg
- Oryza sativa ext. 10 g
- Calcified lithothamnion (Red algae) 156 mg equiv. calcium 50 mg
Practitioner product
Per 12 g:
- L-glycine 1.5 g
- Withania somnifera ext. 150 mg
- Magnesium citrate 1.85 g equiv. magnesium 300 mg
- Potassium phosphate dibasic 222.7 mg equiv. potassium 100 mg
- L-glutamine 1.5 g
- Taurine 1.5 g
- Ascorbic acid (Vitamin C) 250 mg
- Calcium pantothenate (Vitamin B5) 50 mg equiv. pantothenic acid 45.8 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 78.4 mg equiv. pyridoxine 50 mg
- Zinc citrate dihydrate 46.7 mg equiv. zinc 15 mg
Practitioner product
Per 6 g:
Practitioner product
Per 16 g (French Vanilla):
- Glycine 1.5 g
- Hydrolysed bovine collagen peptides 10 g
- Ascorbic acid (Vitamin C) 250 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 15.7 mg equiv. pyridoxine 10 mg
- Hydroxocobalamin (Vitamin B12) 200 μg
- Zinc citrate dihydrate 47 mg equiv. zinc 15 mg
- Taurine 350 mg
- Choline bitartrate 30 mg
- Thiamine hydrochloride (Vitamin B1) 21.6 mg equiv. thiamine 17 mg
- Riboflavin 5-phosphate sodium (Activated B2) 6.58 mg equiv. riboflavin 5 mg
- Niacinamide (Vitamin B3) 50 mg
- Calcium pantothenate (Vitamin B5) 54.6 mg equiv. pantothenic acid 50 mg
- Levomefolate glucosamine (Activated folate) 360 μg equiv. levomefolic acid 200 μg
- Biotin 50 μg
- Cholecalciferol 10 μg equiv. vitamin D3 400 IU
- Magnesium citrate 330 mg equiv. magnesium 50 mg
- Calcified lithothamnion (Red algae) 156 mg equiv. calcium 50 mg
- Manganese gluconate 8.1 mg equiv. manganese 1 mg
- Selenomethionine 125 μg equiv. selenium 50 μg
- Chromium nicotinate 194 μg equiv. chromium 24 μg
- Molybdenum trioxide 75 μg equiv. molybdenum 50 μg
- Potassium iodide 66 μg equiv. iodine 50 μg
- Silybum marianum ext. 150 mg
- Zingiber officinale ext. 50 mg
Practitioner product
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This monograph was last reviewed on 12/04/2024 10:00:00. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
