Background

Hesperidin is a plant chemical that's classified as a "bioflavonoid." It's most commonly found in citrus fruits such as oranges. People use it as medicine.

Hesperidin might help blood vessels function better. It might also reduce swelling.

People use hesperidin for diabetes, high blood pressure, athletic performance, and many other conditions, but there is no scientific evidence to support any uses.

Safety Safety definitions

When taken by mouth: Hesperidin is commonly consumed from citrus fruits. Hesperidin supplements are possibly safe for most people when taken in doses of 3 grams daily for up to 3 months. It's usually well tolerated.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Hesperidin is commonly consumed from citrus fruits. It is possibly safe to take hesperidin in larger doses with another plant chemical called diosmin when pregnant or breast-feeding.

Bleeding disorder: Hesperidin might slow blood clotting and increase the risk of bleeding. Hesperidin might make bleeding disorders worse.

Surgery: Hesperidin might increase the risk of bleeding or cause extra sleepiness during and after surgical procedures. Stop taking hesperidin at least 2 weeks before a scheduled surgery.

Effectiveness

Dosing & administration

Hesperidin is found in citrus fruits such as oranges. In supplements, hesperidin has most often been used by adults in doses of 450-1000 mg by mouth daily for 6-12 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Interactions with pharmaceuticals

Celiprolol (Celicard)

Interaction Rating=Moderate Be cautious with this combination.

Hesperidin may reduce how much celiprolol the body absorbs. This might decrease the effects of celiprolol.

Diltiazem (Cardizem, others)

Interaction Rating=Moderate Be cautious with this combination.

Hesperidin may reduce how much diltiazem the body absorbs. This might decrease the effects of diltiazem.

Medications for high blood pressure (Antihypertensive drugs)

Interaction Rating=Moderate Be cautious with this combination.

Hesperidin might lower blood pressure. Taking hesperidin along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

Medications moved by pumps in cells (P-glycoprotein substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are moved in and out of cells by pumps. Hesperidin might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Interaction Rating=Moderate Be cautious with this combination.

Hesperidin might slow blood clotting. Taking hesperidin along with medications that also slow blood clotting might increase the risk of bruising and bleeding and others.

Sedative medications (CNS depressants)

Interaction Rating=Moderate Be cautious with this combination.

Hesperidin might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking hesperidin with sedative medications might cause breathing problems and/or too much sleepiness.

Verapamil (Calan, others)

Interaction Rating=Moderate Be cautious with this combination.

Hesperidin may increase how much verapamil the body absorbs. This might increase the effects and side effects of verapamil.

Interactions with herbs & supplements

Herbs and supplements that might lower blood pressure: Hesperidin might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much. Examples of supplements with this effect include andrographis, casein peptides, L-arginine, niacin, and stinging nettle.
Herbs and supplements that might slow blood clotting: Hesperidin might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.
Herbs and supplements with sedative properties: Hesperidin might cause sleepiness and slowed breathing. Taking it along with other supplements with similar effects might cause too much sleepiness and/or slowed breathing in some people. Examples of supplements with this effect include hops, kava, L-tryptophan, melatonin, and valerian.

Interactions with foods

There are no known interactions with foods.