Histidine
Scientific names: Histidine
Alternate names: (2S)-2-Amino-3-(1H-Imidazol-5-yl) Propanoic Acid, (S)-4-(2-Amino-2-Carboxyethyl) Imidazole, Histidina, L-Histidine, L-Histidine AKG, L-Histidine-Alpha Ketoglutaric Acid, L-Histidine HCl, Levo-Histidine, (S)-Alpha-Amino-1H-imidazole-4-Propanoic Acid
Background
Histidine is an essential amino acid. It is not made by the body, but is consumed in foods. Amino acids are the building blocks of protein.
Histidine is involved in many different metabolic processes in the body.
People use histidine for diarrhea due to cholera infection, eczema, kidney failure, metabolic syndrome, and many other conditions, but there is no good scientific evidence to support these uses.
Histidine is involved in many different metabolic processes in the body.
People use histidine for diarrhea due to cholera infection, eczema, kidney failure, metabolic syndrome, and many other conditions, but there is no good scientific evidence to support these uses.
Safety Safety definitions
When taken by mouth: Histidine is commonly consumed as part of the diet. Histidine supplements are possibly safe when used short-term. Doses of up to 4 grams daily have been used safely for up to 12 weeks. It seems to be well-tolerated.
Folic acid deficiency: People with folic acid deficiency should avoid histidine. It can cause an unwanted chemical called formiminoglutamic acid (FIGLU) to build up in the body.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Histidine is commonly consumed as part of the diet. There isn't enough reliable information to know if histidine is safe to use in larger amounts as medicine when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.Folic acid deficiency: People with folic acid deficiency should avoid histidine. It can cause an unwanted chemical called formiminoglutamic acid (FIGLU) to build up in the body.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- An infection of the intestines that causes diarrhea (cholera). Drinking a solution containing histidine seems to reduce diarrhea in people with cholera who are also receiving antibiotics.
Dosing & administration
Histidine is a natural part of the diet. L-histidine supplements have most often been used by adults in doses of 4 grams by mouth daily. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Interactions with pharmaceuticals
It is not known if Histidine interacts with any medicines. Before taking Histidine, talk with your healthcare professional if you take any medications.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
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Per 37 g:
- Histidine hydrochloride 185.25 mg equiv. l-histidine 150 mg
- Glutamine 2.22 g
- L-leucine 1.68 g
- Lysine hydrochloride 451.03 mg equiv. lysine 361 mg
- L-isoleucine 450 mg
- L-valine 450 mg
- L-phenylalanine 200 mg
- L-threonine 200 mg
- Cysteine hydrochloride 45 mg equiv. cysteine 31.04 mg
- L-methionine 120 mg
- L-tyrosine 112.5 mg
- L-aspartic acid 111 mg
- L-proline 111 mg
- L-serine 27.75 mg
- Glycine 27.75 mg
- L-alanine 27.75 mg
- Taurine 11 mg
- Levocarnitine tartrate (L-carnitine) 10.99 mg equiv. levocarnitine 7.5 mg
- Potassium citrate 402.6 mg equiv. potassium 145.74 mg
- Magnesium citrate 167.09 mg equiv. magnesium 27 mg
- Magnesium glycerophosphate 49.99 mg equiv. magnesium 6.25 mg
- Calcium phosphate 62.64 mg equiv. calcium 25 mg
- Calcium glycerophosphate 393.27 mg equiv. calcium 75 mg
- Ferrous fumarate 45.6 mg equiv. iron 1.5 mg
- Manganese sulphate monohydrate 1.02 g equiv. manganese 330 µg
- Zinc sulphate monohydrate 5.74 mg equiv. zinc 2.08 mg
- Selenomethionine 28.64 µg equiv. selenium 11.54 µg
- Copper sulfate pentahydrate 656.27 µg equiv. copper 167 µg
- Molybdenum trioxide 12 µg equiv. molybdenum 8 µg
- Chromic chloride hexahydrate 46.95 µg equiv. chromium 9.16 µg
- Chromium picolinate 30.89 µg equiv. chromium 3.84 µg
- Potassium iodide 22.25 µg equiv. iodine 17 µg
- Borax 2.2 mg equiv. boron 250 µg
- Choline bitartrate 80.84 mg equiv. choline 33.25 mg
- Sodium ascorbate (Vitamin C) 22.5 mg equiv. ascorbic acid 20 mg
- dl-alpha-Tocopheryl acetate 10 mg equiv. vitamin E 10 IU
- Nicotinamide (Vitamin B3) 3.25 mg
- Retinol palmitate 418.58 µg equiv. vitamin A 767 IU
- Pyridoxine hydrochloride (Vitamin B6) 790 µg equiv. pyridoxine 650 µg
- Cholecalciferol 1.65 µg equiv. vitamin D3 66 IU
- Riboflavin (Vitamin B2) 500 µg
- Thiamine nitrate (Vitamin B1) 616.83 µg equiv. thiamine 500 µg
- Folic acid 31.27 µg
- Biotin 50 µg
- Calcium pantothenate (Vitamin B5) 3.53 mg equiv. pantothenic acid 3.25 mg
- Phytomenadione (Vitamin K1) 10 µg
- Cyanocobalamin (Vitamin B12) 2 µg
- Glucose monohydrate (Dextrose) 12.5 g
- Sunflower lecithin 250 mg
- Levomefolate glucosamine (Activated folate) 8 µg equiv. levomefolic acid 4.5 µg
- Medium Chain Triglycerides (powder) (MCT) 3 g
Practitioner product
Per capsule:
Practitioner product
Per 7 g (Lemonade):
- L-histidine
- Schisandra chinensis ext. equiv. dry 2.5 g
- L-leucine
- L-isoleucine
- L-methionine
- L-threonine
- L-valine
- L-lysine
- L-phenylalanine
- L-tryptophan
- Calcium citrate
- Magnesium bisglycinate
- Flavour
- Silica - colloidal anhydrous
- Ascorbic acid (Vitamin C)
- Potassium citrate
- Pyridoxal 5-phosphate (P5P)
- Methylcobalamin (Activated B12)
- Stevia rebaubiana
420 g Lemonade
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Per 12 g (Juicy Peach):
- Total Amino blend Amino9™ 2 g
- L-histidine
- L-leucine 2 g
- L-valine 1 g
- L-isoleucine 1 g
- L-isoleucine
- L-leucine
- L-lysine
- L-methionine
- L-phenylalanine
- L-threonine
- L-valine
- L-tryptophan
- L-glutamine 1 g
- Sodium chloride (Salt)
- Potassium chloride
- Calcium citrate
- Magnesium sulphate
- Ananas comosus (Bromelain) 25 mg
- Natural flavours
- Citric acid monohydrate
- Stevia rebaubiana
- Polyphenolic fulvic minerals 10 mg
- Tart cherry extract 250 mg
- Curcuma longa 50 mg
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$98.75
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Per 30 g (Tropical Crush):
- L-histidine
- Hydrolysed pea protein
- L-alanine
- Glycine
- L-valine
- L-leucine
- L-isoleucine
- L-proline
- L-phenylalanine
- L-tyrosine
- L-serine
- L-threonine
- L-methionine
- L-arginine
- L-lysine
- L-aspartic acid
- L-glutamic acid
- L-tryptophan
- L-cysteine
- Natural flavours
- Cichorium intybus (root) (Chicory)
- Acacia sp. (gum)
- Coconut water powder
- Medium chain triglycerides (MCT)
- Potassium citrate
- Magnesium citrate
- Sodium chloride (Salt)
- Calcium citrate
- Ascorbic acid (Vitamin C)
- Citric acid anhydrous
- Stevia rebaubiana
- Thaumatin
- Beta-carotene
- Riboflavin (Vitamin B2)
$59.95
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Per 33 g (Banana Ice-Cream):
RRP: $79.99$70.39Save: 12%
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RRP: $49.95$41.21Save: 17%
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Per 30 g (Chocolate):
- Egg albumen powder
- Natural flavours
- Stevia rebaubiana
- Theobroma cacao
900 g Chocolate
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Per 30 g (Cacao):
- Pea protein isolate 25.2 g
- Dunaliella salina equiv. beta-carotene 390 µg
- Aloe barbadensis 1 g
- Malpighia glabra equiv. vitamin C 50 mg
- d-alpha-Tocopheryl acid succinate 2.5 mg
- Natural chocolate flavour
- Stevia rebaubiana
- Thaumatin
- Luo Han Guo (fruit) ext. (Monk fruit)
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Per 30 g (Choc Sea Salt):
- Pea protein isolate
- Pumpkin powder
- Citrullus lanatus (Watermelon)
- Cannabis sativa (seed) powder
- Schizochytrium sp. (Chromista algae oil)
- d-alpha-Tocopherol
- Medium Chain Triglycerides (powder) (MCT)
- Amylase enzyme 3840 µg
- Protease 960 µg
- Lactase 640 µg
- Lipase 160 µg
- Cellulase 32 µg
- Flavour
- Pink Himalayan crystal salt
- Theobroma cacao
- Stevia rebaubiana
900 g Choc Sea Salt
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1 kg Chocolate
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Per 30 g (Banana Cinnamon):
- Pea protein isolate
- Pumpkin seed protein
- Citrullus lanatus (Watermelon)
- Bacillus coagulans 50 mg
- Natural flavours
- Cinnamomum spp. powder
- Stevia rebaubiana
- Amylase enzyme
- Cellulase
- Lipase
- Lactase
- Protease
900 g Banana Cinnamon
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Per 30 g (Vanilla):
- Golden pea protein (sprout) bio-fermented
- Plukenetia volubilis (Sacha Inchi protein)
- Arthrospira platensis (Spirulina)
- Spinacia oleracea (Spinach)
- Sweet potato powder
- Cucurbita pepo (seed)
- Sunflower seed
- Linum usitatissimum (seed) (Flaxseed)
- Millet
- Quinoa powder
- Chia (seed)
- Molasses (Cane juice)
- Ananas comosus (Bromelain)
- Acacia sp. (gum)
- Stevia rebaubiana
- Natural flavours
- Medicago sativa
- Pouteria lucuma (fruit) powder
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Per 48 g:
- Whey protein concentrate
- Whey protein isolate
- Soy lecithin
- Theobroma cacao (Cocoa powder)
- Medium Chain Triglycerides (powder) (MCT)
- Calcium phosphate dibasic
- Flavour
- Magnesium citrate
- Cyamopsis tetragonoloba (Guar gum)
- Calcium citrate
- Zinc gluconate
- Ascorbic acid (Vitamin C)
- Beta-carotene carotenoids (Vitamin A)
- Chromium chloride
- Ferrous fumarate
- d-alpha-Tocopheryl acetate
- Calcium pantothenate (Vitamin B5)
- Riboflavin (Vitamin B2)
- Sodium selenite
- Thiamine hydrochloride (Vitamin B1)
- Cyanocobalamin (Vitamin B12)
- Biotin
- Potassium iodide
- Sodium molybdate
- Niacinamide (Vitamin B3)
- Copper sulfate
- Manganese citrate
- Cholecalciferol
- Folic acid
- Pyridoxine hydrochloride (Vitamin B6)
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Per 30 g (Creamy Vanilla):
- Pea protein isolate
- Vaccinium corymbosum powder
- Rubus idaeus powder
- Euterpe oleracea (berry) ext. (Acai)
- Medium chain triglycerides (MCT)
- Natural flavours
- Linum usitatissimum (seed) (Flaxseed)
- Plantago ovata (husk) (Psyllium)
- Sunflower seed
- Quinoa powder
- Amaranth powder
- L-leucine
- L-isoleucine
- L-valine
- L-glutamine
- Levocarnitine (L-carnitine)
- Stevia rebaubiana
- Fagopyrum esculentum powder
1 kg Creamy Vanilla
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Per 30 g (Triple Chocolate):
- Golden pea protein (sprout) bio-fermented
- Natural flavours
- Sea mineral complex
- Spinacia oleracea (Spinach)
- Arthrospira platensis (Spirulina)
- Chlorella pyrenoidosa powder
- Cinnamomum verum powder
- Glycyrrhiza glabra powder
- Zingiber officinale powder
- Taraxacum officinale powder
- Ginkgo biloba powder
- Eleutherococcus senticosus powder
- Silybum marianum powder
- Capsicum spp. powder
- Centella asiatica powder
- Syzygium aromaticum powder
- Stevia rebaubiana (leaf) ext.
- Ananas comosus (Bromelain)
- Theobroma cacao (Cocoa powder)
- Acacia sp. (gum)
1 kg Triple Chocolate
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This monograph was last reviewed on 30/04/2023 10:00:00 and last updated on 27/02/2013 16:39:56. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
