Hu zhang
Scientific names: Polygonum cuspidatum, Fallopia japonica, Reynoutria japonica
Family: Polygonaceae
Alternate names: Bambou Japonais, Bambou Mexicain, Extrait de Hu Zhang, Fleece Flower, Giant Knotweed, He Shou Wu, Hojang-Geun, Huzhang, Itadori, Itadori-Kon, Japanese Bamboo, Japanese Knotweed, Japanese Knotwood, Mexican Bamboo, PCWE, Persicaire Cuspidée, Polygoni Multiflora, Racine de Hu Zhang, Renouée à Feuilles Pointues, Renouée du Japon, Renouée Japonaise, Tiger Cane
Actions: Antiallergic, Antibacterial, Anti-inflammatory, Antilipemic, Antineoplastic, Antioxidant, Antiviral, Bone, Cardiovascular, Coagulation, Estrogenic, Neurologic, Xanthine oxidase inhibition
Background
Hu zhang (Polygonum cuspidatum) is a plant native to Asia. The root is commonly used as part of traditional medicine in countries throughout Asia.
Hu zhang contains chemicals that might reduce symptoms of allergies. It also contains chemicals that might have anti-inflammatory and antioxidant effects.
People use hu zhang for hay fever, diabetes, gout, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.
Hu zhang contains chemicals that might reduce symptoms of allergies. It also contains chemicals that might have anti-inflammatory and antioxidant effects.
People use hu zhang for hay fever, diabetes, gout, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.
Safety Safety definitions
When taken by mouth: There isn't enough reliable information to know if hu zhang is safe or what the side effects might be.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Hu zhang might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use hu zhang until more is known.
Surgery: Hu zhang contains resveratrol. Resveratrol is a chemical that might slow blood clotting. Hu zhang might increase the risk of bleeding during and after surgery. Stop using hu zhang at least 2 weeks before a scheduled surgery.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if hu zhang is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Hu zhang might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use hu zhang until more is known.
Surgery: Hu zhang contains resveratrol. Resveratrol is a chemical that might slow blood clotting. Hu zhang might increase the risk of bleeding during and after surgery. Stop using hu zhang at least 2 weeks before a scheduled surgery.
Effectiveness
Effective Effectiveness definitions
There is interest in using hu zhang for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Dosing & administration
There isn't enough reliable information to know what an appropriate dose of hu zhang might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
Interactions with pharmaceuticals
Carbamazepine (Tegretol)
Interaction Rating=Minor Be watchful with this combination.
Hu zhang might slow down how quickly the body breaks down carbamazepine. This might increase the amount of carbamazepine in the body and increase the risk of side effects. If you take carbamazepine, talk to your healthcare provider before taking hu zhang.
Estrogens
Interaction Rating=Moderate Be cautious with this combination.
Hu zhang seems to have some of the same effects as estrogen. Taking hu zhang along with estrogens might decrease the effects of estrogens.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Hu zhang might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Hu zhang might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Hu zhang might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Hu zhang might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Moderate Be cautious with this combination.
Hu zhang might slow blood clotting. Taking hu zhang along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Interactions with herbs & supplements
Herbs and supplements that might slow blood clotting: Hu zhang might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.
Interactions with foods
There are no known interactions with foods.
Products
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Practitioner product
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Practitioner product
Per capsule:
- Reynoutria japonica (Giant Knotweed) ext. 260 mg equiv. resveratrol 130 mg
- Schisandra chinensis ext. 240 mg
- Brassica oleracea var. italica ext. 400 mg
- Punica granatum ext. 200 mg
- Ascorbic acid (Vitamin C) 80 mg
- Citrus bioflavonoids extract 40 mg
- Selenomethionine 149.2 µg equiv. selenium 60 µg
- Angelica polymorpha ext. 400 mg
- Silybum marianum ext. 200 mg
- Zinc citrate dihydrate 37.4 mg equiv. zinc 12 mg
- Chromium picolinate 402.4 µg equiv. chromium 50 µg
- Mecobalamin (Vitamin B12) 4 µg
- Curcuma longa ext. 300 mg
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Per capsule:
- Reynoutria japonica (Giant Knotweed) ext. 225 mg equiv. resveratrol 112.5 mg
- Zinc citrate dihydrate 15.6 mg equiv. zinc 5 mg
- Total Vitamin C 152.9 mg
- Calcium ascorbate dihydrate (Vitamin C) 125.5 mg equiv. ascorbic acid 103.7 mg
- Ascorbyl palmitate (Vitamin C) 45 mg equiv. ascorbic acid 19.1 mg
- Ascorbic acid (Vitamin C) 30.1 mg
- Beta-carotene carotenoids (Vitamin A) 2.7 mg
- Reduced glutathione 50 mg
- Vitis vinifera ext. 60.4 mg
- Silybum marianum ext. 18.8 mg
- Vaccinium myrtillus ext. 1 mg
- Retinol acetate 300 μg equiv. vitamin A 261 μg RE
- Riboflavin (Vitamin B2) 5 mg
- Nicotinamide (Vitamin B3) 20 mg
- R,S-alpha lipoic acid 20 mg
- Selenomethionine 248.6 μg equiv. selenium 100 μg
- Lycopersicon esculentum (Tomato) 8.3 mg equiv. lycopene 500 μg equiv. fresh fruit 2.9 g
- Palm tocotrienols complex (Vitamin E) 20 mg equiv. mixed tocopherols 900 μg
Practitioner product
Per 8 g (Orange):
- Reynoutria japonica (Giant Knotweed) ext. 200 mg equiv. resveratrol 100 mg
- Acetyl levocarnitine hydrochloride (Acetyl-L-carnitine) 1 g
- Levocarnitine (L-carnitine) 250 mg
- Ubidecarenone (Coenzyme Q10) 30 mg
- Selenomethionine 148.8 μg equiv. selenium 60 μg
- Zinc citrate dihydrate 31.92 mg equiv. zinc 10 mg
- Magnesium citrate 1.85 g equiv. magnesium 300 mg
- Inositol 1 g
- Rutin (Rutoside) 750 mg
- R-alpha lipoic acid 50 mg
- Nicotinamide (Vitamin B3) 50 mg
- Calcium pantothenate (Vitamin B5) 100 mg equiv. pantothenic acid 91.6 mg
- Manganese amino acid chelate 20 mg equiv. manganese 2 mg
- Palm tocotrienols complex (Vitamin E) 5 mg
- Biotin 3 mg
- Riboflavin 5-phosphate sodium (Activated B2) 10 mg equiv. riboflavin 7.6 mg
Practitioner product
Per capsule:
- Reynoutria japonica (Giant Knotweed) ext. 76.5 mg equiv. resveratrol 75 mg
- Nicotinamide riboside chloride (Vitamin B3) 75 mg equiv. ribose 34.4 mg
- Ganoderma lucidum ext. 100 mg
- Vitis vinifera ext. 120 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 15.7 mg equiv. pyridoxine 10 mg
- Menaquinone 7 (Vitamin K2) 45 µg
- Pinus radiata ext. 50 mg
- Vaccinium myrtillus ext. 20 mg
- Rosmarinus officinalis ext. 50 mg
- Hydroxocobalamin (Vitamin B12) 400 µg
- Calcium folinate (Activated folate) 434 µg equiv. folinic acid 400 µg
- Riboflavin 5-phosphate sodium (Activated B2) 10.4 mg equiv. riboflavin 7.6 mg
- Thiamine hydrochloride (Vitamin B1) 12.7 mg equiv. thiamine 10 mg
Practitioner product
Per tablet:
- Reynoutria japonica (Giant Knotweed) ext. 100 mg equiv. resveratrol 50 mg
- Riboflavin 5-phosphate sodium (Activated B2) 7.7 mg equiv. riboflavin 5.63 mg
- Pyridoxal 5-phosphate (P5P) 5.36 mg equiv. pyridoxine 3.42 mg
- Silybum marianum ext. 263 mg
- Rosmarinus officinalis ext. 75 mg
- Choline bitartrate 100 mg
- Potassium iodide 98.1 μg equiv. iodine 75 μg
- Molybdenum trioxide 93.8 μg equiv. molybdenum 62.5 μg
- Zinc citrate dihydrate 31.15 mg equiv. zinc 10 mg
- Calcium folinate (Activated folate) 217 μg equiv. folinic acid 200 μg
- Mecobalamin (Vitamin B12) 250 μg
- Curcuma longa ext. 125 mg
- Selenomethionine 186.3 μg equiv. selenium 75 μg
- Camellia sinensis ext. 157 mg
Practitioner product
Practitioner product
Per tablet:
- Fallopia japonica (Japanese knotweed) ext. 125 mg equiv. resveratrol 25 mg
- Panax ginseng ext. 50 mg
- Cholecalciferol 12.5 μg equiv. vitamin D3 500 IU
- Zinc sulphate monohydrate 41 mg equiv. zinc 15 mg
- Camellia sinensis ext. 200 mg
- Phytomenadione (Vitamin K1) 2.5 mg
- Selenomethionine 188 μg equiv. selenium 75 μg
- Molybdenum trioxide 94 μg equiv. molybdenum 62.5 μg
- Curcuma longa ext. 76 mg
Practitioner product
Practitioner product
Per capsule:
- Reynoutria japonica (Giant Knotweed) ext. 50 mg equiv. resveratrol 25 mg
- Vitis vinifera ext. 4.167 mg
- Ginkgo biloba ext. 6 mg
- Curcuma longa ext. 30 mg
- Vaccinium myrtillus ext. 1 mg
- Ascorbic acid (Vitamin C) 120 mg
- Silybum marianum ext. 11.43 mg
- Camellia sinensis ext. 50 mg
- Rutin (Rutoside) 100 mg
- Selenomethionine 125 μg equiv. selenium 50 μg
- Beta-carotene carotenoids (Vitamin A) 3 mg
- Glycine 50 mg
- Cysteine hydrochloride monohydrate 50 mg
- Glutamine 50 mg
- d-alpha-Tocopheryl acid succinate 82.64 mg equiv. vitamin E 100 IU
- Tocopherols concentrate - mixed (low-alpha type) 5 mg
- Zinc citrate dihydrate 15.58 mg equiv. zinc 5 mg
Practitioner product
Per 4 g:
- Reynoutria japonica (Giant Knotweed) ext. 75 mg equiv. resveratrol 15 mg
- Total Vitamin C 2.4 g
- Ascorbic acid (Vitamin C) 1.77 g
- Sodium ascorbate (Vitamin C) 300 mg equiv. ascorbic acid 265.2 mg
- Calcium ascorbate dihydrate (Vitamin C) 280 mg equiv. ascorbic acid 230 mg
- Magnesium ascorbate monohydrate (Vitamin C) 80 mg equiv. ascorbic acid 68 mg
- Zinc ascorbate monohydrate (Vitamin C) 80 mg equiv. ascorbic acid 65 mg
- Citrus bioflavonoids extract 96 mg
- Citrus bioflavonoids extract 96 mg
- Rutin (Rutoside) 96 mg
- Quercetin 48 mg
- R,S-alpha lipoic acid 50 mg
Practitioner product
Per tablet:
- Reynoutria japonica (Giant Knotweed) ext. 20 mg equiv. resveratrol 10 mg
- Asparagus racemosus ext. 70.58 mg
- Vitex agnus-castus ext. 25 mg
- Retinol acetate 354 μg equiv. vitamin A 300 μg RE
- Thiamine hydrochloride (Vitamin B1) 50 mg
- Riboflavin (Vitamin B2) 30 mg
- Nicotinamide (Vitamin B3) 50 mg
- Calcium pantothenate (Vitamin B5) 50 mg equiv. pantothenic acid 45.8 mg
- Cyanocobalamin (Vitamin B12) 150 μg
- Folic acid 500 μg
- Ascorbic acid (Vitamin C) 100 mg
- Cholecalciferol 25 μg equiv. vitamin D3 1000 IU
- d-alpha-Tocopheryl acid succinate 41.3 mg equiv. vitamin E 50 IU
- Tocopherols concentrate - mixed (low-alpha type) 20 mg
- Biotin 150 μg
- Phytomenadione (Vitamin K1) 30 μg
- Choline bitartrate 25 mg
- Inositol 25 mg
- Calcium hydrogen phosphate dihydrate 258.2 mg equiv. calcium 60 mg equiv. phosphorous 46.47 mg
- Magnesium amino acid chelate 150 mg equiv. magnesium 30 mg
- Iron amino acid chelate 50 mg equiv. iron 5 mg
- Borax 26.5 mg equiv. boron 3 mg
- Zinc amino acid chelate 25 mg equiv. zinc 5 mg
- Manganese amino acid chelate 20 mg equiv. manganese 2 mg
- Chromium chloride hexahydrate 1.28 mg equiv. chromium 250 μg
- Potassium iodide (Iodine) 391 μg equiv. iodine 299 μg equiv. potassium 92 μg
- Molybdenum trioxide 150 μg equiv. molybdenum 100 μg
- Selenomethionine 124.2 μg equiv. selenium 50 μg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 41 mg
Practitioner product
Per tablet:
- Reynoutria japonica (Giant Knotweed) ext. 20 mg equiv. resveratrol 10 mg
- Mecobalamin (Vitamin B12) 150 μg
- Hydroxocobalamin (Vitamin B12) 350 μg
- Calcium ascorbate dihydrate (Vitamin C) 121 mg equiv. ascorbic acid 100 mg
- Cholecalciferol 12.5 μg equiv. vitamin D3 500 IU
- d-alpha-Tocopheryl acid succinate (Vitamin E) 24.6 mg equiv. d-alpha-tocopherol 29.8 IU
- Zinc citrate dihydrate 46.7 mg equiv. zinc 15 mg
- Beta-carotene carotenoids (Vitamin A) 3 mg
- Thiamine hydrochloride (Vitamin B1) 50 mg equiv. thiamine 39.3 mg
- Riboflavin 5-phosphate sodium (Activated B2) 34.2 mg equiv. riboflavin 25 mg
- Nicotinamide (Vitamin B3) 100 mg
- Calcium pantothenate (Vitamin B5) 109 mg equiv. pantothenic acid 100 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 31.4 mg equiv. pyridoxine 20 mg
- Levomefolate calcium (Activated folate) 434 μg equiv. levomefolic acid 400 μg
- Calcium folinate (Activated folate) 109 μg equiv. folinic acid 100 μg
- Biotin 150 μg
- Choline dihydrogen citrate 56.5 mg
- Menaquinone 7 (Vitamin K2) 25 μg
- Chromium nicotinate 402 μg equiv. chromium 50 μg
- Manganese amino acid chelate 5 mg equiv. manganese 500 μg
- Molybdenum trioxide 90 μg equiv. molybdenum 60 μg
- Potassium iodide 131 μg equiv. iodine 100 μg
- Sodium selenate 179 μg equiv. selenium 75 μg
- Citrus bioflavonoids extract 22.2 mg
- Iron bisglycinate 18.3 mg equiv. iron 5 mg
- Tagetes erecta ext. 10 mg
Practitioner product
Per 10 g:
- Fallopia japonica (Japanese knotweed)
- Pea protein isolate
- Malus (Apple)
- Apple pectin
- Arthrospira platensis (Spirulina)
- Linum usitatissimum (seed) (Flaxseed)
- Sunflower lecithin
- Marine algae
- Wheatgrass powder
- Beta vulgaris (root) powder (Beetroot)
- Brassica oleracea var. italica (Broccoli)
- Chlorella pyrenoidosa powder
- Spinacia oleracea (Spinach)
- Daucus carota powder (Carrot)
- Zingiber officinale
- Glycyrrhiza glabra (root)
- Cynara scolymus
- Ribes nigrum
- Vitis vinifera
- Malpighia glabra
- Vaccinium myrtillus
- Camellia sinensis
- Rosa canina
- Centella asiatica
- Silybum marianum
- Rhodiola rosea
- Rosmarinus officinalis
- Withania somnifera
- Taraxacum officinale
- Lycium chinese (berry)
- Citric acid anhydrous
- Citrus bioflavonoids extract
- R,S-alpha lipoic acid
- Beta glucan
- Ubiquinol-10 (Coenzyme Q10)
- Dunaliella salina
- Lactobacillus acidophilus
- Bifidobacterium bifidum
- Potassium phosphate dibasic
- Magnesium citrate
- Ascorbic acid (Vitamin C)
- Natural vanilla flavour
- Natural pineapple flavour
- Zinc citrate
- Tocopherols concentrate - mixed (Vitamin E)
- Selenomethionine
- D-calcium pantothenate (Vitamin B5)
- Nicotinamide (Vitamin B3)
- Pyridoxine hydrochloride (Vitamin B6)
- Retinyl palmitate
- Cholecalciferol
- Copper gluconate
- Thiamine hydrochloride (Vitamin B1)
- Riboflavin (Vitamin B2)
- Folate
- Chromium picolinate
- Panax ginseng
- Fucus vesiculosus
- Stevia rebaubiana (leaf)
- Phytomenadione (Vitamin K1)
- Biotin
- Cyanocobalamin (Vitamin B12)
- Lentinula edodes (fruiting body)
- Ulmus rubra (bark inner) powder
- Hordeum vulgare
- Plantago ovata (husk) (Psyllium)
- Theobroma cacao
- Tocopherols concentrate - mixed (Vitamin E)
- Astragalus membranaceus
- Manganese gluconate
- Menaquinone 7 (Vitamin K2)
- Amylase enzyme
- Protease
- Lipase
- Cellulase
- Lactase
- Euterpe oleracea (berry) ext. (Acai)
- Bacopa monnieri
- Salvia officinalis
- Vaccinium macrocarpon
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
