Hydroxymethylbutyrate (hmb)
Scientific names: Beta-hydroxy-beta-methylbutyrate
Alternate names: B-Hydroxy B-Methylbutyrate Monohydrate, Beta-Hydroxy-Beta-Methylbutyric Acid, Calcium B-Hydroxy B-Methylbutyrate Monohydrate, Calcium HMB, Hidroximetilbutirato, HMB, HMB de Calcium, Hydroxyméthylbutyrate, Hydroxymethyl Butyrate, Hydroxyméthyl Butyrate
Actions: Muscular, Immunomodulation, Renal, Wound-healing
Background
Hydroxymethylbutyrate (HMB) is a chemical that is made when the body breaks down leucine. Leucine is an amino acid, one of the building blocks of protein.
HMB might promote muscle growth. It can be found naturally in small amounts in grapefruit, alfalfa, and catfish. It's also naturally made in the body.
People use HMB for building muscle or preventing age-related muscle loss. It's also used for athletic performance, muscle loss due to HIV/AIDS, muscle strength, obesity, and many other purposes, but there is no good scientific evidence to support these uses.
HMB might promote muscle growth. It can be found naturally in small amounts in grapefruit, alfalfa, and catfish. It's also naturally made in the body.
People use HMB for building muscle or preventing age-related muscle loss. It's also used for athletic performance, muscle loss due to HIV/AIDS, muscle strength, obesity, and many other purposes, but there is no good scientific evidence to support these uses.
Safety Safety definitions
When taken by mouth: HMB is possibly safe. Doses of up to 3 grams daily for up to one year have been used safely.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if HMB is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Age-related muscle loss (sarcopenia). Taking HMB by mouth seems to increase muscle mass and might slow the loss of muscle in older adults. But it might not help any more than exercise.
Possibly ineffective Effectiveness definitions
- Physical performance in elderly adults. Taking HMB by mouth while participating in an exercise program doesn't improve physical performance any more than participating in the exercise program alone.
Dosing & administration
HMB and a calcium salt of HMB (Ca-HMB) have most often been used by adults in doses of 2.4-3 grams by mouth daily. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.
Interactions with pharmaceuticals
It is not known if Hydroxymethylbutyrate (HMB) interacts with any medicines. Before taking Hydroxymethylbutyrate (HMB), talk with your healthcare professional if you take any medications.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
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This monograph was last reviewed on 01/05/2024 10:00:00 and last updated on 06/12/2021 07:32:38. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
