Ip-6
Scientific names: Inositol hexaphosphate
Alternate names: Acide Phytique, Calcium Magnesium Inositol Hexaphosphate, Calcium Phytate, Fytic Acid, InsP6, Phytate, Hexaphosphate d'Inositol, Hexaphosphate d'Inositol de Calcium Magnésium, Phytate de Calcium, Phytic Acid
Background
IP-6, inositol hexaphosphate, is a vitamin-like substance. It is found in humans, animals, and many plants, especially cereals, nuts, and legumes. It can also be made in a laboratory.
Some people use IP-6 to treat and prevent cancer, to reduce side effects of cancer treatment, for anemia, diabetes, and many other conditions, but there is no good scientific evidence to support these uses.
In manufacturing, IP-6 is added to food to keep it from spoiling.
Some people use IP-6 to treat and prevent cancer, to reduce side effects of cancer treatment, for anemia, diabetes, and many other conditions, but there is no good scientific evidence to support these uses.
In manufacturing, IP-6 is added to food to keep it from spoiling.
Safety Safety definitions
When taken by mouth: IP-6 is LIKELY SAFE when used in amounts found in foods. IP-6 is POSSIBLY SAFE when used as a medicine, short-term. Taking IP-6, 600 mg two times per day for up to 2 weeks, appears to be safe. There isn't enough reliable information to know if IP-6 is safe when used long-term or in larger amounts.
When applied to the skin: There isn't enough reliable information to know if IP-6 is safe or what the side effects might be.
Clotting disorders: IP-6 might slow blood clotting. If you have a clotting disorder, use IP-6 with caution.
Iron-deficiency anemia: IP-6 binds with iron in the gastrointestinal (GI) tract. This reduces the amount of iron that the body absorbs from food and supplements.
Weak and brittle bones (osteoporosis): IP-6 binds with calcium in the gastrointestinal (GI) tract. This reduces the amount of calcium that the body absorbs from food and supplements. This might worsen osteoporosis.
Surgery: Since IP-6 might slow blood clotting, there is a concern that it might increase the risk of extra bleeding during and after surgery. Stop using IP-6 at least 2 weeks before a scheduled surgery.
When applied to the skin: There isn't enough reliable information to know if IP-6 is safe or what the side effects might be.
Special Precautions & Warnings:
Pregnancy and breast-feeding: IP-6 is LIKELY SAFE for pregnant and breast-feeding women when used in food amounts. But there isn't enough reliable information to know if larger medicinal amounts of IP-6 are safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.Clotting disorders: IP-6 might slow blood clotting. If you have a clotting disorder, use IP-6 with caution.
Iron-deficiency anemia: IP-6 binds with iron in the gastrointestinal (GI) tract. This reduces the amount of iron that the body absorbs from food and supplements.
Weak and brittle bones (osteoporosis): IP-6 binds with calcium in the gastrointestinal (GI) tract. This reduces the amount of calcium that the body absorbs from food and supplements. This might worsen osteoporosis.
Surgery: Since IP-6 might slow blood clotting, there is a concern that it might increase the risk of extra bleeding during and after surgery. Stop using IP-6 at least 2 weeks before a scheduled surgery.
Effectiveness
Effective Effectiveness definitions
There is interest in using IP-6 for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Dosing & administration
The appropriate dose of IP-6 depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for IP-6. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Interactions with pharmaceuticals
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Moderate Be cautious with this combination.
IP-6 nicotinate might slow blood clotting. Taking IP-6 along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Interactions with herbs & supplements
Calcium: IP-6 binds with calcium in the gastrointestinal (GI) tract. This reduces the amount of calcium that the body absorbs from food and supplements.
Herbs and supplements that might slow blood clotting: IP-6 might slow blood clotting. Using IP-6 along with other natural products that can also slow blood clotting might increase the risk of bruising and bleeding. These products include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, turmeric, and others.
Iron: IP-6 binds with iron in the gastrointestinal (GI) tract. This reduces the amount of iron that the body absorbs from food and supplements.
Zinc: IP-6 binds with zinc in the gastrointestinal (GI) tract. This reduces the amount of zinc that the body absorbs from food and supplements.
Herbs and supplements that might slow blood clotting: IP-6 might slow blood clotting. Using IP-6 along with other natural products that can also slow blood clotting might increase the risk of bruising and bleeding. These products include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, turmeric, and others.
Iron: IP-6 binds with iron in the gastrointestinal (GI) tract. This reduces the amount of iron that the body absorbs from food and supplements.
Zinc: IP-6 binds with zinc in the gastrointestinal (GI) tract. This reduces the amount of zinc that the body absorbs from food and supplements.
Interactions with foods
There are no known interactions with foods.
Action
IP-6 might help treat and prevent cancer by slowing down the production of cancer cells. It might also bind to certain minerals, decreasing the risk of colon cancer. IP-6 is also an antioxidant.
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This monograph was last reviewed on 03/10/2024 10:00:00 and last updated on 29/12/2021 06:43:37. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
