Kinetin
Scientific names: Kinetin
Alternate names: 6-Furfurylaminopurine, 9-(b-D-Ribofuranosyl)-6-furfurylaminopurine, Cinetina, K, Kinerase, Kinetase, Kinetin Riboside, Kinetina, Kinétine, Kn, N-(2-furanylmethyl)-1H-purin-6-amine, N(6)furfuryladenine, N6-furfuryladenine, Quinetina
Actions: Anti-aging, Antioxidant, Antiplatelet, Chemoprotective, Cytotoxic, Differentiation, Other
Background
Kinetin is a cytokinin. Cytokinins are compounds that stimulate plants to grow. Kinetin occurs naturally in humans and is sometimes used to make medicine.
People use kinetin most often for aging skin, skin wrinkles from sun damage, and a skin condition that causes redness on the face (rosacea), but there is no good scientific evidence to support these uses.
People use kinetin most often for aging skin, skin wrinkles from sun damage, and a skin condition that causes redness on the face (rosacea), but there is no good scientific evidence to support these uses.
Safety Safety definitions
When taken by mouth: There isn't enough reliable information to know if kinetin is safe. It might cause side effects such as nausea, headache, diarrhea, rash, and ringing in the ears.
When applied to the skin: Kinetin is POSSIBLY SAFE when used in a cream or lotion containing kinetin 0.1% for up to 12 weeks. It might cause side effects such as redness, dryness, peeling, burning, stinging, and itching in some people. But it isn't clear if these symptoms are from kinetin or another ingredient in the products used.
When applied into the ear: There isn't enough reliable information to know if kinetin is safe or what the side effects might be.
Bleeding disorders: There is some concern that kinetin might prolong bleeding time and increase the risk of bruising and bleeding in some people with bleeding disorders. If you have a bleeding disorder, use kinetin with caution.
Surgery: Kinetin might increase the risk of bleeding during and after surgery. Stop taking kinetin at least 2 weeks before a scheduled surgery.
When applied to the skin: Kinetin is POSSIBLY SAFE when used in a cream or lotion containing kinetin 0.1% for up to 12 weeks. It might cause side effects such as redness, dryness, peeling, burning, stinging, and itching in some people. But it isn't clear if these symptoms are from kinetin or another ingredient in the products used.
When applied into the ear: There isn't enough reliable information to know if kinetin is safe or what the side effects might be.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if kinetin is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Bleeding disorders: There is some concern that kinetin might prolong bleeding time and increase the risk of bruising and bleeding in some people with bleeding disorders. If you have a bleeding disorder, use kinetin with caution.
Surgery: Kinetin might increase the risk of bleeding during and after surgery. Stop taking kinetin at least 2 weeks before a scheduled surgery.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Insufficient evidence Effectiveness definitions
- A skin condition that causes redness on the face (rosacea). Early research shows that applying a lotion containing kinetin helps to reduce most symptoms of rosacea, like roughness and redness, in most people. But it doesn't seem to help everyone.
- Skin wrinkles from sun damage. Early research shows that applying a lotion containing kinetin to the face helps to reduce wrinkles and to improve the feeling of the skin in people who have wrinkled skin from the sun.
- Aging skin.
- An inner ear disorder marked by dizziness, hearing loss, and ringing in the ear (Meniere disease).
- Skin imperfections.
- Other conditions.
Dosing & administration
The appropriate dose of kinetin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for kinetin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Interactions with pharmaceuticals
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Moderate Be cautious with this combination.
Kinetin might slow blood clotting in some people. Taking kinetin along with medications that also slow clotting might increase the chances of bruising and bleeding in some people.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Interactions with herbs & supplements
Herbs and supplements that might slow clotting: Kinetin might slow blood clotting. Using it with other herbs that have the same effect could increase the risk of bleeding in some people. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, turmeric, and others.
Interactions with foods
There are no known interactions with foods.
Action
Kinetin prevents green plant leaves from turning brown. There is some information that suggests kinetin might prevent age-related changes in human skin by protecting the DNA in skin cells from damage (antioxidant effects) and decreasing skin water loss.
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This monograph was last reviewed on 17/10/2023 11:00:00 and last updated on 29/10/2020 19:33:53. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
