Ligandrol
Alternate names: Anabolicum, LGD-4033, VK5211
Background
Ligandrol is a type of chemical known as a selective androgen receptor modulator (SARM). It mimics the activity of testosterone in the body.
Ligandrol attaches to proteins in the body known as androgen receptors and is believed to have muscle building effects.
People use ligandrol for athletic performance, breast cancer, muscle strength, and many other conditions, but there is no good scientific evidence to support these uses. Using ligandrol might also be unsafe.
In the US, it is illegal to include SARMS, including ligandrol, in supplement products. But it is still found in some supplement products. These chemicals are also banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA). Ligandrol can be detected in urine tests.
Ligandrol attaches to proteins in the body known as androgen receptors and is believed to have muscle building effects.
People use ligandrol for athletic performance, breast cancer, muscle strength, and many other conditions, but there is no good scientific evidence to support these uses. Using ligandrol might also be unsafe.
In the US, it is illegal to include SARMS, including ligandrol, in supplement products. But it is still found in some supplement products. These chemicals are also banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA). Ligandrol can be detected in urine tests.
Safety Safety definitions
When taken by mouth: Ligandrol is possibly unsafe. It's been used under medical supervision for up to 3 weeks, but there are concerns about serious side effects, including liver damage, heart attack, stroke, and others. The US FDA warns that dietary supplements containing selective androgen receptor modulators (SARMs) are dangerous.
Liver disease: Ligandrol might cause liver problems. Ligandrol might make existing liver disease worse.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Ligandrol is possibly unsafe when used during pregnancy or breast-feeding. It's been linked with serious side effects. Avoid use.Liver disease: Ligandrol might cause liver problems. Ligandrol might make existing liver disease worse.
Effectiveness
Effective Effectiveness definitions
There is interest in using ligandrol for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Dosing & administration
There isn't enough reliable information to know what an appropriate dose of ligandrol might be. It might also be unsafe. The US FDA warns that dietary supplements containing selective androgen receptor modulators (SARMs), including ligandrol, are dangerous. Speak with a healthcare provider before use.
Interactions with pharmaceuticals
Medications that can harm the liver (Hepatotoxic drugs)
Interaction Rating=Moderate Be cautious with this combination.
Ligandrol might harm the liver. Some medications can also harm the liver. Taking ligandrol along with a medication that can harm the liver might increase the risk of liver damage.
Interactions with herbs & supplements
Herbs and supplements that might harm the liver: Ligandrol might harm the liver. Taking it with other supplements that can also harm the liver might increase the risk of liver damage. Examples of supplements with this effect include garcinia, greater celandine, green tea extract, kava, and kratom.
Interactions with foods
There are no known interactions with foods.
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This monograph was last reviewed on 31/01/2024 11:00:00. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
