N,n-dimethylphenethylamine (n,n-dmpea)
Alternate names: AF 2975, AF-2975, AF2975, Dimethylphenethylamine, Dimethyl-phenethyl-amine, Eria Jarensis Extract
Actions: General, Dry eye
Background
N,N-dimethylphenethylamine (N,N-DMPEA) is a chemical. It is a form of phenethylamine.
Some people apply N,N-DMPEA to the eyes for dry eye or take N,N-DMPEA by mouth for weight loss and athletic performance. But there is no good scientific evidence to support these uses.
N,N-DMPEA is also used in small amounts for flavoring in foods.
Some people apply N,N-DMPEA to the eyes for dry eye or take N,N-DMPEA by mouth for weight loss and athletic performance. But there is no good scientific evidence to support these uses.
N,N-DMPEA is also used in small amounts for flavoring in foods.
Safety Safety definitions
When taken by mouth: N,N-DMPEA is LIKELY SAFE when used in small amounts for food flavor. N,N-DMPEA is POSSIBLY UNSAFE when taken by mouth in medicinal amounts. Stroke has been reported by a woman who took a supplement that listed N,N-DMPEA and other ingredients on the label.
When applied into the eye: N,N-DMPEA is POSSIBLY SAFE when applied into the eye as eye drops for up to 21 days.
When applied into the eye: N,N-DMPEA is POSSIBLY SAFE when applied into the eye as eye drops for up to 21 days.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if N,N-DMPEA is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Insufficient evidence Effectiveness definitions
- Dry eye. Early research suggests that using N,N-DMPEA eye drops can improve the composition of tears in people with dry eyes.
- Athletic performance.
- Obesity.
- Other conditions.
Dosing & administration
The appropriate dose of N,N-DMPEA depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for N,N-DMPEA. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Interactions with pharmaceuticals
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. N,N-DMPEA might decrease how quickly the liver breaks down some medications. Taking N,N-DMPEA along with some medications that are changed by the liver might increase the effects and side effects of your medication. Before taking N,N-DMPEA, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
Interactions with herbs & supplements
Phenethylamine: Taking N,N-DMPEA with phenethylamine may cause kidney damage in some people.
Interactions with foods
There are no known interactions with foods.
Action
N,N-DMPEA might affect certain chemicals in the brain. But there isn't enough reliable information available to know how N,N-DMPEA might work in humans.
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This monograph was last reviewed on 19/02/2024 11:00:00 and last updated on 09/07/2020 21:37:57. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
