Nicotinamide riboside
Scientific names: Nicotinamide riboside
Alternate names: Nicotinamide Ribose, NR, Riboside de nicotinamide
Actions: General, Exercise, Hepatic, Metabolic, Neuroprotective
Background
Nicotinamide riboside is a member of the vitamin B3 family, which also includes niacin and niacinamide. It's found in fruits, vegetables, meat, and milk.
Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels can cause health problems. Taking nicotinamide riboside can help raise low NAD+ levels.
People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, and many other purposes, but there is no good scientific evidence to support these uses.
Don't confuse nicotinamide riboside with niacin, niacinamide, or NADH. These are all related but are not the same.
Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels can cause health problems. Taking nicotinamide riboside can help raise low NAD+ levels.
People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, and many other purposes, but there is no good scientific evidence to support these uses.
Don't confuse nicotinamide riboside with niacin, niacinamide, or NADH. These are all related but are not the same.
Safety Safety definitions
When taken by mouth: Nicotinamide riboside chloride is possibly safe when used in doses up to 300 mg daily. Side effects are usually mild and might include nausea, bloating, and skin problems such as itching and sweating.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Nicotinamide riboside chloride is possibly safe when used in doses up to 230 mg by mouth daily while pregnant or breast-feeding.Effectiveness
Effective Effectiveness definitions
There is interest in using nicotinamide riboside for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Dosing & administration
There isn't enough reliable information to know what an appropriate dose of nicotinamide riboside might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
Interactions with pharmaceuticals
Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating=Moderate Be cautious with this combination.
Nicotinamide riboside might lower blood pressure. Taking nicotinamide riboside along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Interactions with herbs & supplements
Herbs and supplements that might lower blood pressure: Nicotinamide riboside might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much. Examples of supplements with this effect include andrographis, casein peptides, L-arginine, niacin, and stinging nettle.
Interactions with foods
There are no known interactions with foods.
Products
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Per 7.5 g:
- Nicotinamide riboside chloride (Vitamin B3) 100 mg equiv. ribose 52 mg
- D-Ribose 4.6 g
- Acetyl levocarnitine hydrochloride (Acetyl-L-carnitine) 1 g
- Calcium pyruvate 666 mg equiv. calcium 100 mg
- Magnesium citrate 647 mg equiv. magnesium 100 mg
- Calcium pantothenate (Vitamin B5) 65 mg equiv. pantothenic acid 60 mg
- Taurine 50 mg
- Biotin 1 mg
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Per capsule:
- Nicotinamide riboside chloride (Vitamin B3) 75 mg equiv. ribose 34.4 mg
- Ganoderma lucidum ext. 100 mg
- Vitis vinifera ext. 120 mg
- Reynoutria japonica ext. 76.5 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 15.7 mg equiv. pyridoxine 10 mg
- Menaquinone 7 (Vitamin K2) 45 µg
- Pinus radiata ext. 50 mg
- Vaccinium myrtillus ext. 20 mg
- Rosmarinus officinalis ext. 50 mg
- Hydroxocobalamin (Vitamin B12) 400 µg
- Calcium folinate (Activated folate) 434 µg equiv. folinic acid 400 µg
- Riboflavin 5-phosphate sodium (Activated B2) 10.4 mg equiv. riboflavin 7.6 mg
- Thiamine hydrochloride (Vitamin B1) 12.7 mg equiv. thiamine 10 mg
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Per tablet:
- Nicotinamide (Vitamin B3) 220 mg
- Nicotinic acid (Vitamin B3) 5 mg
- Thiamine hydrochloride (Vitamin B1) 50 mg equiv. thiamine 44.6 mg
- Pyridoxine hydrochloride (Vitamin B6) 48.62 mg equiv. pyridoxine 40 mg
- Riboflavin 5-phosphate sodium (Activated B2) 27.4 mg equiv. riboflavin 20 mg
- Mecobalamin (Vitamin B12) 500 μg
- Selenomethionine 65 μg equiv. selenium 26 μg
- Retinol acetate 884 μg equiv. vitamin A 750 μg RE
- Calcium pantothenate (Vitamin B5) 100 mg equiv. pantothenic acid 91.6 mg equiv. calcium 8.4 mg
- Calcium folinate (Activated folate) 278 μg equiv. folinic acid 200 μg
- Levomefolate calcium (Activated folate) 216 μg equiv. levomefolic acid 200 μg
- Calcium ascorbate dihydrate (Vitamin C) 121.7 mg equiv. ascorbic acid 100 mg equiv. calcium 11.44 mg
- Cholecalciferol 2.5 μg equiv. vitamin D3 100 IU
- d-alpha-Tocopheryl acid succinate 28 mg equiv. vitamin E 34 IU
- Tocopherols concentrate - mixed (low-alpha type) 13.5 mg
- R,S-alpha lipoic acid 10 mg
- Biotin 150 μg
- Ananas comosus (Bromelain) 6 mg
- Choline bitartrate 40 mg
- Cysteine hydrochloride monohydrate 21.74 mg equiv. cysteine 15 mg
- L-glutamine 40 mg
- Citrus bioflavonoids extract 5 mg
- Inositol 25 mg
- Lecithin 15 mg
- Rutin (Rutoside) 10 mg
- Taurine 85 mg
- Chromium nicotinate 205 μg equiv. chromium 25 μg
- Potassium iodide (Iodine) 41 μg equiv. iodine 31 μg equiv. potassium 9.6 μg
- Magnesium phosphate pentahydrate 50 mg equiv. magnesium 10 mg
- Manganese amino acid chelate 250 μg equiv. manganese 50 μg
- Potassium phosphate dibasic 31.82 mg equiv. potassium 14 mg
- Zinc amino acid chelate 72 mg equiv. zinc 14.4 mg
- Molybdenum trioxide 75 μg equiv. molybdenum 50 μg
- Rosa canina ext. 10 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 10 mg equiv. pyridoxine 6.38 mg
- Citrus bioflavonoids extract 5 mg
- Lysine hydrochloride 35 mg equiv. lysine 27.45 mg
- Copper gluconate 43 μg equiv. copper 6 μg
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Per tablet:
- Nicotinamide (Vitamin B3) 200 mg
- Glucosamine sulphate potassium chloride 663 mg equiv. glucosamine sulphate 500 mg
- Boswellia serrata ext. 66.7 mg
- Curcuma longa ext. 4 mg
- Sodium ascorbate (Vitamin C) 112.5 mg equiv. ascorbic acid 100 mg
- Magnesium orotate dihydrate 103.6 mg equiv. magnesium 6.6 mg
- Manganese amino acid chelate 50 mg equiv. manganese 5 mg
- Cholecalciferol 2.5 μg equiv. vitamin D3 100 IU
- Silybum marianum ext. 5 mg
- Vitis vinifera ext. 1 mg
Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 200 mg
- Glucosamine sulphate potassium chloride 663 mg equiv. glucosamine sulphate 500 mg equiv. potassium chloride 163 mg
- Cholecalciferol 2.5 µg equiv. vitamin D3 100 IU
- Boswellia serrata ext. 57.1 mg
- Sodium ascorbate (Vitamin C) 112.5 mg equiv. ascorbic acid 100 mg
- Lecithin 100 mg
- Magnesium orotate dihydrate 103.58 mg equiv. magnesium 6.7 mg
- Manganese amino acid chelate 25 mg equiv. manganese 5 mg
- Silybum marianum ext. 5 mg
- Vitis vinifera ext. 1 mg
- Curcuma longa ext. 4 mg
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Per tablet:
- Nicotinamide (Vitamin B3) 187.5 mg
- Calcium pantothenate (Vitamin B5) 546 mg equiv. pantothenic acid 500 mg
- Zinc gluconate 57.43 mg equiv. zinc 7.5 mg
- Retinyl acetate 206.4 μg equiv. vitamin A 175 μg RE
- Biotin 500 μg
- Urtica dioica ext. 93.75 mg
- Copper gluconate 2.7 mg equiv. copper 375 μg
- Silica - colloidal anhydrous 26.7 mg equiv. silicon 12.5 mg
- Folic acid 125 μg
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Practitioner product
Per capsule:
- Nicotinamide (Vitamin B3) 150 mg
- Calcium folinate (Activated folate) 542 μg equiv. folinic acid 500 μg
- Hydroxocobalamin (Vitamin B12) 500 μg
- Thiamine hydrochloride (Vitamin B1) 63.5 mg equiv. thiamine 50 mg
- Riboflavin 5-phosphate sodium (Activated B2) 26.3 mg equiv. riboflavin 20 mg
- Calcium pantothenate (Vitamin B5) 218.3 mg equiv. pantothenic acid 200 mg
- Pyridoxal 5-phosphate (P5P) 31.3 mg equiv. pyridoxine 20 mg
- Inositol 100 mg
- Biotin 500 μg
Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 150 mg
- Thiamine nitrate (Vitamin B1) 100 mg equiv. thiamine 81.1 mg
- Riboflavin (Vitamin B2) 50 mg
- Calcium pantothenate (Vitamin B5) 110 mg equiv. pantothenic acid 100.8 mg
- Pyridoxine hydrochloride (Vitamin B6) 75 mg equiv. pyridoxine 61.7 mg
- Folic acid 150 µg
- Cyanocobalamin (Vitamin B12) 150 µg
- Biotin 150 µg
- Choline bitartrate 137.5 mg
- Inositol 100 mg
- Camellia sinensis ext. 113.75 mg
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Per 10 g (Guava Lemonade):
- Nicotinamide riboside chloride (Vitamin B3) 150 mg
- Total Magnesium 360 mg
- Magnesium aspartate dihydrate 1.4 g equiv. magnesium 105 mg
- Magnesium glycerophosphate 1.15 g equiv. magnesium 127 mg
- Magnesium citrate 792.1 mg equiv. magnesium 128 mg
- Taurine 3 g
- Potassium aspartate 47.6 mg equiv. potassium 10 mg
Practitioner product
Per capsule:
- Nicotinamide (Vitamin B3) 130 mg
- Riboflavin 5-phosphate sodium (Activated B2) 25 mg equiv. riboflavin 19.7 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 23.5 mg equiv. pyridoxine 15 mg
- Calcium pantothenate (Vitamin B5) 196.5 mg equiv. pantothenic acid 180 mg
- Thiamine hydrochloride (Vitamin B1) 63.6 mg equiv. thiamine 50 mg
- Biotin 500 μg
Practitioner product
Per capsule:
- Nicotinamide (Vitamin B3) 130 mg
- Pyridoxal 5-phosphate (P5P) 23.6 mg equiv. pyridoxine 15 mg
- Calcium folinate (Activated folate) 436.9 μg equiv. folinic acid 402.6 μg
- Hydroxocobalamin (Vitamin B12) 400 μg
- Calcium pantothenate (Vitamin B5) 196 mg equiv. pantothenic acid 180 mg
- Thiamine hydrochloride (Vitamin B1) 63.5 mg equiv. thiamine 50 mg
- Biotin 500 μg
- Riboflavin 5-phosphate sodium (Activated B2) 31.8 mg equiv. riboflavin 25 mg
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Per tablet:
- Nicotinamide (Vitamin B3) 125 mg
- Calcium pantothenate (Vitamin B5) 500 mg equiv. pantothenic acid 458 mg
- Biotin 330 μg
- Retinol acetate 135.7 μg equiv. vitamin A 115 μg RE
- Folic acid 80 μg
- Copper gluconate 1.8 mg equiv. copper 0.25 mg
- Zinc gluconate 38.29 mg equiv. zinc 5 mg
- Silica - colloidal anhydrous 10.7 mg equiv. silicon 5 mg
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This monograph was last reviewed on 19/02/2024 11:00:00 and last updated on 31/03/2022 04:53:47. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
