![<img src='https://images.vital.ly/monographs/tr:w-800,c-at_max,dpr-2,q-100/Nicotinamide_riboside_vital_ly.png' /> Nicotinamide riboside](https://images.vital.ly/monographs/tr:w-800,c-at_max,dpr-2,q-100/Nicotinamide_riboside_vital_ly.png)
Nicotinamide riboside
Scientific names: Nicotinamide riboside
Alternate names: Nicotinamide Ribose, NR, Riboside de nicotinamide
Actions: General, Exercise, Hepatic, Metabolic, Neuroprotective
Background
Nicotinamide riboside is a member of the vitamin B3 family, which also includes niacin and niacinamide. It's found in fruits, vegetables, meat, and milk.
Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels can cause health problems. Taking nicotinamide riboside can help raise low NAD+ levels.
People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, and many other purposes, but there is no good scientific evidence to support these uses.
Don't confuse nicotinamide riboside with niacin, niacinamide, or NADH. These are all related but are not the same.
Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels can cause health problems. Taking nicotinamide riboside can help raise low NAD+ levels.
People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, and many other purposes, but there is no good scientific evidence to support these uses.
Don't confuse nicotinamide riboside with niacin, niacinamide, or NADH. These are all related but are not the same.
Safety Safety definitions
When taken by mouth: Nicotinamide riboside chloride is possibly safe when used in doses up to 300 mg daily. Side effects are usually mild and might include nausea, bloating, and skin problems such as itching and sweating.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Nicotinamide riboside chloride is possibly safe when used in doses up to 230 mg by mouth daily while pregnant or breast-feeding.Effectiveness
Effective Effectiveness definitions
There is interest in using nicotinamide riboside for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Dosing & administration
There isn't enough reliable information to know what an appropriate dose of nicotinamide riboside might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
Interactions with pharmaceuticals
Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating=Moderate Be cautious with this combination.
Nicotinamide riboside might lower blood pressure. Taking nicotinamide riboside along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Interactions with herbs & supplements
Herbs and supplements that might lower blood pressure: Nicotinamide riboside might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much. Examples of supplements with this effect include andrographis, casein peptides, L-arginine, niacin, and stinging nettle.
Interactions with foods
There are no known interactions with foods.
Products
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Per 7.5 g:
- Nicotinamide riboside chloride (Vitamin B3) 100 mg equiv. ribose 52 mg
- D-Ribose 4.6 g
- Acetyl levocarnitine hydrochloride (Acetyl-L-carnitine) 1 g
- Calcium pyruvate 666 mg equiv. calcium 100 mg
- Magnesium citrate 647 mg equiv. magnesium 100 mg
- Calcium pantothenate (Vitamin B5) 65 mg equiv. pantothenic acid 60 mg
- Taurine 50 mg
- Biotin 1 mg
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Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 220 mg
- Thiamine hydrochloride (Vitamin B1) 56 mg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 41 mg
- Riboflavin (Vitamin B2) 30 mg
- Cyanocobalamin (Vitamin B12) 400 μg
- Calcium pantothenate (Vitamin B5) 105 mg
- Taurine 125 mg
- L-glutamine 100 mg
- Ascorbic acid (Vitamin C) 75 mg
- Potassium phosphate dibasic 50 mg equiv. potassium 22 mg
- Choline bitartrate 50 mg
- Lecithin 50 mg
- L-lysine 50 mg
- Potassium aspartate 50 mg equiv. potassium 10 mg
- Calcium hydrogen phosphate dihydrate 49 mg equiv. calcium 12 mg
- Magnesium citrate 44 mg equiv. magnesium 7 mg
- Zinc sulphate monohydrate 42 mg equiv. zinc 15 mg
- Tocopherols concentrate - mixed (low-alpha type) (Vitamin E) 15 mg equiv. d-alpha tocopherol 2.5 mg
- Borax 4.4 mg equiv. boron 500 μg
- Chromium nicotinate 500 μg equiv. chromium 50 μg
- Folic acid 395 μg
- Selenomethionine 63 μg equiv. selenium 25 μg
- Manganese sulphate monohydrate 55 μg equiv. manganese 18 μg
- Biotin 50 μg
- Potassium iodide (Iodine) 46 μg equiv. iodine 35 μg equiv. potassium 11 μg
- Copper gluconate 43 μg equiv. copper 6 μg
- Cholecalciferol 1 μg
- Iron bisglycinate 50 mg equiv. iron 10 mg
- Dunaliella salina ext. 67 mg
Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 220 mg
- Nicotinic acid (Vitamin B3) 5 mg
- Thiamine hydrochloride (Vitamin B1) 50 mg equiv. thiamine 43.26 mg
- Pyridoxine hydrochloride (Vitamin B6) 50.13 mg equiv. pyridoxine 40 mg
- Riboflavin 5-phosphate sodium (Activated B2) 27.4 mg equiv. riboflavin 20 mg
- Mecobalamin (Vitamin B12) 500 μg
- Selenomethionine 64.58 μg equiv. selenium 26 μg
- Retinol acetate 884 μg equiv. vitamin A 750 μg RE
- Calcium pantothenate (Vitamin B5) 100 mg equiv. pantothenic acid 88 mg equiv. calcium 8.4 mg
- Calcium folinate (Activated folate) 278 μg equiv. folinic acid 200 μg
- Levomefolate calcium (Activated folate) 216.56 μg equiv. levomefolic acid 200 μg
- Calcium ascorbate dihydrate (Vitamin C) 121 mg equiv. ascorbic acid 100 mg equiv. calcium 11.4 mg
- Cholecalciferol 2.5 μg equiv. vitamin D3 100 IU
- d-alpha-Tocopheryl acid succinate 28 mg equiv. vitamin E 34 IU
- Tocopherols concentrate - mixed (low-alpha type) 13.5 mg
- R,S-alpha lipoic acid 10 mg
- Biotin 150 μg
- Ananas comosus (Bromelain) 6 mg
- Choline bitartrate 40 mg
- Cysteine hydrochloride 21.74 mg equiv. cysteine 15 mg
- L-glutamine 40 mg
- Citrus bioflavonoids extract 5 mg
- Inositol 25 mg
- Lecithin 15 mg
- Rutin (Rutoside) 10 mg
- Taurine 85 mg
- Chromium nicotinate 208.34 μg equiv. chromium 25 μg
- Potassium iodide (Iodine) 40.55 μg equiv. iodine 31 μg equiv. potassium 9.55 μg
- Magnesium phosphate pentahydrate 48.4 mg equiv. magnesium 10 mg
- Manganese gluconate 438.6 μg equiv. manganese 50 μg
- Potassium phosphate monobasic 48.73 mg equiv. potassium 14 mg
- Zinc gluconate 109.88 mg equiv. zinc 14.35 mg
- Molybdenum trioxide 75 μg equiv. molybdenum 50 μg
- Rosa canina powder 10 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 10 mg equiv. pyridoxine 6.38 mg
- Citrus bioflavonoids extract 5 mg
- Lysine hydrochloride 35 mg equiv. lysine 28 mg
- Cupric citrate hemipentahydrate 17 μg equiv. copper 6 μg
Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 200 mg
- Glucosamine sulphate potassium chloride 663 mg equiv. glucosamine sulphate 500 mg
- Boswellia serrata ext. 66.7 mg
- Curcuma longa ext. 4 mg
- Sodium ascorbate (Vitamin C) 112.5 mg equiv. ascorbic acid 100 mg
- Magnesium orotate dihydrate 103.6 mg equiv. magnesium 6.6 mg
- Manganese amino acid chelate 50 mg equiv. manganese 5 mg
- Cholecalciferol 2.5 μg equiv. vitamin D3 100 IU
- Silybum marianum ext. 5 mg
- Vitis vinifera ext. 1 mg
Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 200 mg
- Glucosamine sulphate potassium chloride 663 mg equiv. glucosamine sulphate 500 mg equiv. potassium chloride 163 mg
- Cholecalciferol 2.5 µg equiv. vitamin D3 100 IU
- Boswellia serrata ext. 57.1 mg
- Sodium ascorbate (Vitamin C) 112.5 mg equiv. ascorbic acid 100 mg
- Lecithin 100 mg
- Magnesium orotate dihydrate 103.58 mg equiv. magnesium 6.7 mg
- Manganese amino acid chelate 25 mg equiv. manganese 5 mg
- Silybum marianum ext. 5 mg
- Vitis vinifera ext. 1 mg
- Curcuma longa ext. 4 mg
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Per tablet:
- Nicotinamide (Vitamin B3) 187.5 mg
- Calcium pantothenate (Vitamin B5) 546 mg equiv. pantothenic acid 500 mg
- Zinc gluconate 57.43 mg equiv. zinc 7.5 mg
- Retinyl acetate 206.4 μg equiv. vitamin A 175 μg RE
- Biotin 500 μg
- Urtica dioica ext. 93.75 mg
- Copper gluconate 2.7 mg equiv. copper 375 μg
- Silica - colloidal anhydrous 26.7 mg equiv. silicon 12.5 mg
- Folic acid 125 μg
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Practitioner product
Per capsule:
- Nicotinamide (Vitamin B3) 150 mg
- Calcium folinate (Activated folate) 542 μg equiv. folinic acid 500 μg
- Hydroxocobalamin (Vitamin B12) 500 μg
- Thiamine hydrochloride (Vitamin B1) 63.5 mg equiv. thiamine 50 mg
- Riboflavin 5-phosphate sodium (Activated B2) 26.3 mg equiv. riboflavin 20 mg
- Calcium pantothenate (Vitamin B5) 218.3 mg equiv. pantothenic acid 200 mg
- Pyridoxal 5-phosphate (P5P) 31.3 mg equiv. pyridoxine 20 mg
- Inositol 100 mg
- Biotin 500 μg
Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 150 mg
- Thiamine nitrate (Vitamin B1) 100 mg equiv. thiamine 81.1 mg
- Riboflavin (Vitamin B2) 50 mg
- Calcium pantothenate (Vitamin B5) 110 mg equiv. pantothenic acid 100.8 mg
- Pyridoxine hydrochloride (Vitamin B6) 75 mg equiv. pyridoxine 61.7 mg
- Folic acid 150 µg
- Cyanocobalamin (Vitamin B12) 150 µg
- Biotin 150 µg
- Choline bitartrate 137.5 mg
- Inositol 100 mg
- Camellia sinensis ext. 113.75 mg
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Per 10 g (Guava Lemonade):
- Nicotinamide riboside chloride (Vitamin B3) 150 mg
- Total Magnesium 360 mg
- Magnesium aspartate dihydrate 1.4 g equiv. magnesium 105 mg
- Magnesium glycerophosphate 1.15 g equiv. magnesium 127 mg
- Magnesium citrate 792.1 mg equiv. magnesium 128 mg
- Taurine 3 g
- Potassium aspartate 47.6 mg equiv. potassium 10 mg
Practitioner product
Per capsule:
- Nicotinamide (Vitamin B3) 130 mg
- Riboflavin 5-phosphate sodium (Activated B2) 25 mg equiv. riboflavin 19.7 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 23.5 mg equiv. pyridoxine 15 mg
- Calcium pantothenate (Vitamin B5) 196.5 mg equiv. pantothenic acid 180 mg
- Thiamine hydrochloride (Vitamin B1) 63.6 mg equiv. thiamine 50 mg
- Biotin 500 μg
Practitioner product
Per capsule:
- Nicotinamide (Vitamin B3) 130 mg
- Calcium pantothenate (Vitamin B5) 196.5 mg equiv. pantothenic acid 180 mg
- Thiamine hydrochloride (Vitamin B1) 63.6 mg equiv. thiamine 50 mg
- Co-methylcobalamin (Vitamin B12) 400 µg
- Biotin 500 µg
- Riboflavin 5-phosphate sodium (Activated B2) 32 mg equiv. riboflavin 25 mg
- Pyridoxal 5-phosphate (P5P) 23.5 mg equiv. pyridoxine 15 mg
- Levomefolate calcium (Activated folate) 433 µg equiv. levomefolic acid 400 µg
Practitioner product
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This monograph was last reviewed on 19/02/2024 11:00:00 and last updated on 31/03/2022 04:53:47. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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