Background

Oleander (Nerium oleander) is a flowering shrub. It contains chemicals called toxic cardiac glycosides, which can lead to death when consumed.

The cardiac glycosides in oleander affect the heart. These chemicals can slow the heart rate down. Some of these chemicals might also kill cancer cells.

People use oleander for heart failure, cancer, epilepsy, and many other conditions, but there is no good scientific evidence to support these uses. There is also no good evidence to support using oleander for COVID-19. Oleander is unsafe to use.

Safety Safety definitions

When taken by mouth: Oleander is likely unsafe. Consuming oleander leaf, oleander leaf tea, or oleander seed has led to deadly poisonings.

When applied to the skin: Oleander is possibly unsafe. It can be absorbed into the body and cause serious side effects. Touching oleander sap can cause a rash.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Taking oleander by mouth is likely unsafe while pregnant or breast-feeding. It might cause an abortion or cause birth defects. There isn't enough reliable information to know if oleander is safe to apply to the skin. Stay on the safe side and avoid use.

Children: Oleander is likely unsafe when taken by mouth. Taking the oleander leaf, oleander leaf tea, or oleander seed has led to deadly poisonings.

Effectiveness

Dosing & administration

There isn't enough reliable information to know what an appropriate dose of oleander might be. Oleander can also be unsafe. Speak with a healthcare provider before using.

Interactions with pharmaceuticals

Antibiotics (Macrolide antibiotics)

Interaction Rating=Major Do not take this combination.

Taking some antibiotics might increase how much oleander the body absorbs. This might increase the effects and side effects of oleander.

Antibiotics (Tetracycline antibiotics)

Interaction Rating=Major Do not take this combination.

Taking some antibiotics might increase how much oleander the body absorbs. This might increase the effects and side effects of oleander.

Digoxin (Lanoxin)

Interaction Rating=Major Do not take this combination.

Digoxin helps the heart beat more strongly. Oleander also seems to affect the heart. Taking oleander along with digoxin can increase the effects of digoxin and might cause serious heart problems. Do not take oleander if you are taking digoxin without talking to your health care professional.

Medications for inflammation (Corticosteroids)

Interaction Rating=Moderate Be cautious with this combination.

Oleander might affect the heart. Some medications for inflammation can decrease potassium in the body. Low potassium levels can also affect the heart. Taking these products together can increase the risk of side effects.

Quinine

Interaction Rating=Major Do not take this combination.

Quinine might increase the amount of oleander the body absorbs. Taking quinine along with oleander might cause serious heart problems.

Stimulant laxatives

Interaction Rating=Major Do not take this combination.

Oleander might affect the heart. Stimulant laxatives can cause diarrhea and decrease potassium levels. Low potassium levels can also affect the heart. Taking these products together can increase the risk of side effects.

Water pills (Diuretic drugs)

Interaction Rating=Major Do not take this combination.

Oleander might affect the heart. "Water pills" can decrease potassium levels. Low potassium levels can also affect the heart. Taking these products together can increase the risk of side effects.

Interactions with herbs & supplements

Calcium: Oleander can stimulate the heartbeat. Calcium might also affect the heart. Taking oleander along with calcium might cause the heart to be too stimulated. Do not take oleander along with calcium supplements.
Herbs that contain cardiac glycosides: Oleander contains chemicals that can affect the heart. These chemicals are called cardiac glycosides. Using it along with other supplements that also contain cardiac glycosides can increase the risk of heart damage. Examples of supplements that contain cardiac glycosides include black hellebore, foxglove, lily-of-the-valley, and pleurisy root.
Horsetail: Oleander contains chemicals that can affect the heart. Horsetail can decrease potassium levels. Low potassium levels can also affect the heart. Taking these products together can increase the risk of side effects.
Licorice: Oleander contains chemicals that can affect the heart. Licorice can decrease potassium levels. Low potassium levels can also affect the heart. Taking these products together can increase the risk of side effects.
Stimulant laxative herbs: Oleander contains chemicals called cardiac glycosides. Using oleander with stimulant laxative herbs increases the risk of heart damage due to loss of too much potassium. Examples of supplements with this effect include aloe, alder buckthorn, gossypol, rhubarb, and senna.

Interactions with foods

There are no known interactions with foods.