Background
Panax ginseng is a plant that grows in Korea, China, and Siberia. It's considered an adaptogen, which are natural substances that are believed to stimulate the body's resistance to stressors. Panax ginseng contains many active chemicals. The most important are called ginsenosides or panaxosides.
Panax ginseng is taken by mouth for memory and thinking skills, Alzheimer disease, depression, and many other conditions, but there is no good scientific evidence to support many of these uses.
Don't confuse Panax ginseng with other plants sometimes referred to as ginseng like American ginseng, Blue Cohosh, Canaigre, Codonopsis, Eleuthero, or Panax Notoginseng. These are different plants with different effects.
Safety Safety definitions
When applied to the skin: There isn't enough reliable information to know if Panax ginseng is safe. It might cause side effects such as irritation and burning.
Special Precautions & Warnings:
Pregnancy: Panax ginseng is possibly unsafe when taken by mouth during pregnancy. One of the chemicals in Panax ginseng has been found to cause birth defects in animals. Do not use Panax ginseng if you are pregnant.Breast-feeding: There isn't enough reliable information to know if Panax ginseng is safe to use when breast-feeding. Stay on the safe side and avoid use.
Children: Panax ginseng is likely unsafe in infants and children. Panax ginseng has been linked to fatal poisoning in newborns. It's not clear if it's safe in older children. Until more is known, do not use Panax ginseng in children.
"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Panax ginseng seems to increase the activity of the immune system. It might make auto-immune diseases worse. Don't use Panax ginseng if you have any auto-immune condition.
Bleeding conditions: Panax ginseng seems to interfere with blood clotting. Don't use Panax ginseng if you have a bleeding condition.
Heart conditions: Panax ginseng can affect heart rhythm and blood pressure slightly on the first day it is used. Use Panax ginseng with caution if you have heart disease.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Panax ginseng contains chemicals (ginsenosides) that can act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use Panax ginseng.
Trouble sleeping (insomnia): High doses of Panax ginseng have been linked with insomnia. If you have trouble sleeping, use Panax ginseng with caution.
Suppressed immune system: Panax ginseng might make the immune system more active. This could interfere with the effects of medications that suppress the immune system, such as those given after an organ transplant. If your immune system is suppressed, don't use Panax ginseng.
Schizophrenia: High doses of Panax ginseng have been linked with sleep problems and agitation in people with schizophrenia. Be careful when using Panax ginseng if you have schizophrenia.
Effectiveness
- Memory and thinking skills (cognitive function). Taking Panax ginseng by mouth might improve thinking, arithmetic skills, and reaction times in healthy, middle-aged people but not in young adults. Taking panax ginseng alone doesn't seem to help memory, but taking it with ginkgo leaf extract seems to improve memory in healthy people between the ages of 38 and 66.
- Erectile dysfunction (ED). Taking Panax ginseng by mouth seems to improve sexual function in adults with ED.
- Flu (influenza). Taking a specific Panax ginseng extract by mouth appears to reduce the risk of getting a cold or the flu. But it doesn't seem to reduce flu symptoms or the length of the illness.
- Fatigue in people with multiple sclerosis (MS). Taking Panax ginseng by mouth daily for 3 months reduces feelings of tiredness and improves quality of life in females with MS.
- Increasing response to sexual stimuli in healthy people. Taking Panax ginseng alone or with other ingredients by mouth seems to improve sexual arousal and satisfaction in postmenopausal adults. It also seems to improve sexual desire in females who report sexual problems.
- Athletic performance. Taking Panax ginseng by mouth for up to 8 weeks doesn't improve athletic performance.
Dosing & administration
Interactions with pharmaceuticals
Caffeine
Interaction Rating=Moderate Be cautious with this combination.
Caffeine can speed up the nervous system. Panax ginseng might also speed up the nervous system. Taking Panax ginseng along with caffeine might increase the risk for side effects, including increased heart rate and high blood pressure. Avoid taking caffeine along with Panax ginseng.
Estrogens
Interaction Rating=Moderate Be cautious with this combination.
Panax ginseng might have some of the same effects as estrogen. Taking Panax ginseng along with estrogen pills might decrease the effects of estrogen.
Fexofenadine (Allegra)
Interaction Rating=Minor Be watchful with this combination.
Fexofenadine is taken to treat seasonal allergies. Panax ginseng might reduce how much fexofenadine is available in the body. But there isn't enough information to know if this is a big concern.
Furosemide (Lasix)
Interaction Rating=Moderate Be cautious with this combination.
Panax ginseng might decrease how well furosemide works. But there isn't enough information to know if this is a big concern.
Imatinib (Gleevec)
Interaction Rating=Moderate Be cautious with this combination.
Panax ginseng might decrease how quickly the liver breaks down imatinib. Taking Panax ginseng with imatinib might increase the effects and side effects of imatinib.
Insulin
Interaction Rating=Moderate Be cautious with this combination.
Panax ginseng might decrease blood sugar. Insulin is also used to decrease blood sugar. Taking Panax ginseng along with insulin might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your insulin might need to be changed.
Lopinavir/Ritonavir (Kaletra)
Interaction Rating=Minor Be watchful with this combination.
Lopinavir/ritonavir is changed and broken down by the liver. Panax ginseng might affect how quickly the liver breaks down some medications. But Panax ginseng does not seem to affect how quickly the liver breaks down lopinavir/ritonavir in humans. So this interaction is probably not a big concern.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Panax ginseng might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Panax ginseng might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications for depression (MAOIs)
Interaction Rating=Moderate Be cautious with this combination.
Taking Panax ginseng with MAOIs might increase the risk for certain side effects, such as anxiousness, headache, restlessness, and insomnia.
Some common MAOIs include phenelzine (Nardil), selegiline (Zelapar), and tranylcypromine (Parnate).
Medications for diabetes (Antidiabetes drugs)
Interaction Rating=Moderate Be cautious with this combination.
Panax ginseng might lower blood sugar levels. Taking panax ginseng along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Medications that can cause an irregular heartbeat (QT interval-prolonging drugs)
Interaction Rating=Moderate Be cautious with this combination.
Panax ginseng might affect electrical currents in the heart. This can increase the risk of having an irregular heartbeat. Some medications can have this same effect. Taking panax ginseng with these medications might increase the risk for a serious heart issue.
Medications that decrease the immune system (Immunosuppressants)
Interaction Rating=Moderate Be cautious with this combination.
Panax ginseng can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking panax ginseng along with these medications might decrease the effects of these medications.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Moderate Be cautious with this combination.
Panax ginseng might slow blood clotting. Taking panax ginseng along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Midazolam (Versed)
Interaction Rating=Moderate Be cautious with this combination.
Panax ginseng might increase how quickly the liver breaks down midazolam. Taking Panax ginseng with midazolam may decrease the effects of midazolam.
Nifedipine (Procardia)
Interaction Rating=Moderate Be cautious with this combination.
Panax ginseng might affect how much nifedipine is available in the body. Taking Panax ginseng along with nifedipine might increase the effects and side effects of nifedipine.
Raltegravir (Isentress)
Interaction Rating=Moderate Be cautious with this combination.
Raltegravir has been associated with liver toxicity in some people. Taking Panax ginseng with raltegravir might increase the risk of liver toxicity in some people taking raltegravir.
Selegiline (Eldepryl)
Interaction Rating=Moderate Be cautious with this combination.
Panax ginseng might decrease or increase how much selegiline is absorbed by the body. This might change the effects and side effects of selegiline.
Stimulant drugs
Interaction Rating=Moderate Be cautious with this combination.
Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Panax ginseng might also speed up the nervous system. Taking Panax ginseng along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with Panax ginseng.
Warfarin (Coumadin)
Interaction Rating=Moderate Be cautious with this combination.
Warfarin is used to slow blood clotting. Panax ginseng might decrease the effects of warfarin. But it's not clear if this interaction is a big problem. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.
Interactions with herbs & supplements
Herbs and supplements that might lower blood sugar: Panax ginseng might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.
Herbs and supplements that might slow blood clotting: Panax ginseng might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, and nattokinase.
Interactions with foods
Products
View all products- Panax ginseng (Korean ginseng) ext. 18 mg equiv. ginsenosides Rg1, Re, Rf, Rg2, Rb1, Rb2, Rc, Rd 4.5 mg
- Eleutherococcus senticosus ext. 116.67 mg
- Withania somnifera ext. 150 mg
- Panax quinquefolius ext. 12 mg
- Ganoderma lucidum ext. 3.75 mg
- L-phenylalanine 75 mg
- L-tyrosine 75 mg
- Calcium pantothenate (Vitamin B5) 55 mg equiv. pantothenic acid 50 mg equiv. calcium 4.6 mg
- Nicotinamide (Vitamin B3) 15 mg
- Nicotinic acid (Vitamin B3) 5 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 6.74 mg equiv. pyridoxine 4.3 mg
- Calcium folinate (Activated folate) 69.5 μg equiv. folinic acid 50 μg
- Cyanocobalamin (Vitamin B12) 5 μg
- Panax ginseng (Korean ginseng) ext. 150 mg
- Withania somnifera ext. 8 mg
- Rehmannia glutinosa ext. 200 mg
- Glycyrrhiza glabra ext. 125 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 5 mg equiv. pyridoxine 3.19 mg
- Schisandra chinensis ext. 100 mg
- Zinc glycinate 35.46 mg equiv. zinc 10 mg
- Chromium picolinate 140.8 μg equiv. chromium 17.5 μg
- Calcium folinate (Activated folate) 54.3 μg equiv. folinic acid 50 μg
- Biotin 35 μg
- Hydroxocobalamin (Vitamin B12) 10 μg
- Calcium pantothenate (Vitamin B5) 10.92 mg equiv. pantothenic acid 10 mg
- Nicotinamide (Vitamin B3) 15 mg
- Riboflavin 5-phosphate sodium (Activated B2) 3.29 mg equiv. riboflavin 2.5 mg
- Thiamine hydrochloride (Vitamin B1) 1.91 mg equiv. thiamine 1.5 mg
- Panax ginseng (Korean ginseng) ext. 50 mg
- Cholecalciferol 12.5 μg equiv. vitamin D3 500 IU
- Zinc sulphate monohydrate 41 mg equiv. zinc 15 mg
- Fallopia japonica ext. 125 mg
- Camellia sinensis ext. 200 mg
- Phytomenadione (Vitamin K1) 2.5 mg
- Selenomethionine 188 μg equiv. selenium 75 μg
- Molybdenum trioxide 94 μg equiv. molybdenum 62.5 μg
- Curcuma longa ext. 76 mg
- Panax ginseng (Korean ginseng) ext. 49.5 mg
- Angelica polymorpha ext. 49.5 mg
- Poria cocos ext. 49.5 mg
- Dimocarpus longan ext. 49.5 mg
- Ziziphus jujuba ext. 33 mg
- Astragalus membranaceus ext. 49.5 mg
- Bupleurum falcatum ext. 49.5 mg
- Gardenia jasminoides ext. 33 mg
- Ziziphus jujuba ext. 49.5 mg
- Zingiber officinale ext. 12 mg
- Glycyrrhiza uralensis ext. 11.5 mg
- Polygala sibirica ext. 49.5 mg
- Atractylodes macrocephala ext. 49.5 mg
- Citrus reticulata ext. 15 mg
- Panax ginseng (Korean ginseng) ext. 15 mg
- Pyridoxine hydrochloride (Vitamin B6) 1.25 mg equiv. pyridoxine 1.03 mg
- Glycyrrhiza glabra ext. 36.36 mg
- Zingiber officinale ext. 20 mg
- Lutein 1.5 mg
- Asparagus racemosus ext. 300 mg
- Thiamine nitrate (Vitamin B1) 1.23 mg equiv. thiamine 1 mg
- Calcium pantothenate (Vitamin B5) 10.87 mg equiv. pantothenic acid 10 mg
- Ascorbic acid (Vitamin C) 60 mg
- Sodium phosphate dibasic anhydrous 100 mg equiv. sodium 32.4 mg
- Potassium phosphate monobasic 139.23 mg equiv. potassium 40 mg
- Zinc glycinate 10.64 mg equiv. zinc 3 mg