Pantethine
Scientific names: (R)-NN'-[Dithiobis(ethyleneaminocarbonylethylene)]bis(2,4-dihydroxy-3,3-dimethylbutyramine), D-bis-(N-Pantothenyl-B-aminoethyl)-disulfide
Alternate names: Bis-pantothenamidoethyl Disulfide, D-Pantethine, D-Pantéthine, Pantesin, Panteteina, Pantetina, Pantéthine, Pantetheine, Pantethine Octahydrate, Pantetina, Pantomin, Pantosin
Actions: Antiparasitic, Cystinosis protective, Lipid-lowering, Neuroprotective, Ocular, Other
Background
Pantethine is chemical that occurs naturally in the body. It's related to vitamin B5 (pantothenic acid).
Pantethine might increase concentrations of some chemicals that lower blood cholesterol and triglycerides in the body.
People use pantethine for lowering levels of cholesterol and triglycerides. It is also used for athletic performance and other purposes, but there is no good scientific evidence to support these uses.
In Japan and China, pantethine is available as a prescription drug for hyperlipidemia. Don't confuse pantethine with pantothenic acid. These are not the same.
Pantethine might increase concentrations of some chemicals that lower blood cholesterol and triglycerides in the body.
People use pantethine for lowering levels of cholesterol and triglycerides. It is also used for athletic performance and other purposes, but there is no good scientific evidence to support these uses.
In Japan and China, pantethine is available as a prescription drug for hyperlipidemia. Don't confuse pantethine with pantothenic acid. These are not the same.
Safety Safety definitions
When taken by mouth: Pantethine is possibly safe when used in doses of up to 1000 mg daily for up to 48 weeks. It might cause nausea, diarrhea, and stomach discomfort in some people.
Bleeding disorders: Pantethine might slow blood clotting. This might increase the risk of severe bleeding in patients with bleeding disorders. If you have a bleeding disorder, talk to your healthcare provider before starting pantethine.
Surgery: Pantethine might slow blood clotting. This might increase the risk of bleeding during and after surgery. Stop using pantethine at least 2 weeks before a scheduled surgery.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if pantethine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Bleeding disorders: Pantethine might slow blood clotting. This might increase the risk of severe bleeding in patients with bleeding disorders. If you have a bleeding disorder, talk to your healthcare provider before starting pantethine.
Surgery: Pantethine might slow blood clotting. This might increase the risk of bleeding during and after surgery. Stop using pantethine at least 2 weeks before a scheduled surgery.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- High levels of lipoproteins in the blood (hyperlipoproteinemia). Taking pantethine by mouth might modestly lower triglycerides, total cholesterol, and low-density lipoprotein (LDL or "bad") cholesterol, and raise high-density lipoprotein (HDL or "good") cholesterol, in people with this inherited condition. But it doesn't seem to work as well as conventional drugs.
Dosing & administration
Pantethine has most often been used by adults in doses of 600-900 mg by mouth daily for 2-3 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Interactions with pharmaceuticals
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Moderate Be cautious with this combination.
Pantethine might slow blood clotting. Taking pantethine along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Interactions with herbs & supplements
Herbs and supplements that might slow blood clotting: Pantethine might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.
Interactions with foods
There are no known interactions with foods.
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This monograph was last reviewed on 22/02/2023 11:00:00 and last updated on 16/05/2022 07:47:33. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
