Phlorizin
Scientific names: Phlorizin
Alternate names: Floridzin, Phloretin-2'-O-glucoside, Phloridzin, Phlorizoside, Phlorrhizin
Actions: Antidiabetic, Antineoplastic, Lipid, Musculoskeletal, Respiratory
Background
Phlorizin is a substance found in some fruit trees, such as the unripe fruit and bark of apple trees. It is used to make medicine.
People use phlorizin for fever, malaria, diabetes, and other conditions, but there is no good scientific evidence to support these uses.
People use phlorizin for fever, malaria, diabetes, and other conditions, but there is no good scientific evidence to support these uses.
Safety Safety definitions
When taken by mouth: There isn't enough reliable information to know if phlorizin is safe or what the side effects might be.
Diabetes: Phlorizin might lower blood sugar. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use phlorizin.
Surgery: Phlorizin might lower blood sugar. There is some concern that it might interfere with blood sugar control during and after surgery. Stop using phlorizin at least 2 weeks before a scheduled surgery.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if phlorizin is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Diabetes: Phlorizin might lower blood sugar. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use phlorizin.
Surgery: Phlorizin might lower blood sugar. There is some concern that it might interfere with blood sugar control during and after surgery. Stop using phlorizin at least 2 weeks before a scheduled surgery.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Insufficient evidence Effectiveness definitions
- Diabetes.
- Fever.
- Malaria.
- Other conditions.
Dosing & administration
The appropriate dose of phlorizin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for phlorizin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Interactions with pharmaceuticals
Medications for diabetes (Antidiabetes drugs)
Interaction Rating=Moderate Be cautious with this combination.
Phlorizin might lower blood sugar. Diabetes medications are also used to lower blood sugar. Taking phlorizin along with diabetes medications might cause blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Interactions with herbs & supplements
Herbs and supplements that might lower blood sugar: Phlorizin might lower blood sugar. Using it with other herbs or supplements that also have this effect might lower blood sugar too much. Other herbs and supplements that might lower blood sugar include banaba, bitter melon, cowhage, ginger, glucomannan, goat's rue, fenugreek, kudzu, willow bark, and others.
Interactions with foods
There are no known interactions with foods.
Action
Phlorizin reduces the uptake and increases the removal of sugar from the blood.
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This monograph was last reviewed on 16/11/2023 11:00:00 and last updated on 23/11/2020 22:29:40. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
