Phosphatidylserine
Scientific names: Phosphatidylserine
Alternate names: BC-PS, Bovine Cortex Phosphatidylserine, Fosfatidilserina, LECI-PS, Lecithin Phosphatidylserine, Phosphatidylsérine, Phosphatidylsérine Bovine, Phosphatidylsérine de Soya, Phosphatidyl Serine, PS, PtdSer, Soy-PS, Soy Phosphatidylserine
Actions: Anti-stress, Coagulation, Brain, Multiple sclerosis
Background
Phosphatidylserine is a chemical that is important for many functions in the human body, especially in the brain. Small amounts are found in most foods.
Phosphatidylserine is part of the cell structure in the body. The body can make phosphatidylserine, but most of what it needs comes from foods. It can also be taken as a supplement. These supplements were once made from cow brain. Now they are commonly made from cabbage or soy.
Phosphatidylserine is used for Alzheimer disease and normal age-related decline in memory and thinking skills. It is also used for athletic performance, ADHD, and many other purposes, but there is no good scientific evidence to support most of these uses.
Phosphatidylserine is part of the cell structure in the body. The body can make phosphatidylserine, but most of what it needs comes from foods. It can also be taken as a supplement. These supplements were once made from cow brain. Now they are commonly made from cabbage or soy.
Phosphatidylserine is used for Alzheimer disease and normal age-related decline in memory and thinking skills. It is also used for athletic performance, ADHD, and many other purposes, but there is no good scientific evidence to support most of these uses.
Safety Safety definitions
When taken by mouth: Phosphatidylserine is possibly safe when used for up to 3 months. Phosphatidylserine can cause side effects such as insomnia and stomach upset, especially at doses over 300 mg.
There's some concern that products made from animal sources can transmit diseases, such as mad cow disease. To date, there aren't any cases of humans getting animal diseases from phosphatidylserine supplements. But stay on the safe side and look for supplements made from plants.
Children: Phosphatidylserine is possibly safe when taken by mouth for up to 4 months in children 4-18 years of age.
There's some concern that products made from animal sources can transmit diseases, such as mad cow disease. To date, there aren't any cases of humans getting animal diseases from phosphatidylserine supplements. But stay on the safe side and look for supplements made from plants.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if phosphatidylserine is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.Children: Phosphatidylserine is possibly safe when taken by mouth for up to 4 months in children 4-18 years of age.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Decline in memory and thinking skills that occurs normally with age. Taking phosphatidylserine that is made from cow brain by mouth seems to improve attention, language skills, and memory in aging people with declining thinking skills. But most phosphatidylserine supplements are now made from soy or cabbage. It's not clear if these supplements have the same effects.
- Alzheimer disease. Taking phosphatidylserine that is made from cow brain by mouth can improve some of the symptoms of Alzheimer disease after 6-12 weeks of treatment. But it might become less effective over time. Most phosphatidylserine supplements are now made from soy or cabbage. It's not clear if these supplements have the same effects.
Dosing & administration
Phosphatidylserine has most often been used by adults in doses of 200-400 mg by mouth daily, for 1-3 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Most phosphatidylserine supplements used to be made from cow brain. This raised concerns about transmitting animal disease, such as mad cow disease, to humans. There aren't any cases of this happening, but most products now come from soy and cabbage. Stay on the safe side and stick with these plant-based products.
Most phosphatidylserine supplements used to be made from cow brain. This raised concerns about transmitting animal disease, such as mad cow disease, to humans. There aren't any cases of this happening, but most products now come from soy and cabbage. Stay on the safe side and stick with these plant-based products.
Interactions with pharmaceuticals
Drying medications (Anticholinergic drugs)
Interaction Rating=Moderate Be cautious with this combination.
Phosphatidylserine can increase a chemical in the body called acetylcholine. Acetylcholine plays a big part in many important body functions. Some medications, called anticholinergic drugs, block the effects of acetylcholine in the body. Taking phosphatidylserine might decrease the effects of anticholinergic drugs.
Various medications used for glaucoma, Alzheimer disease, and other conditions (Cholinergic drugs)
Interaction Rating=Moderate Be cautious with this combination.
Phosphatidylserine can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking phosphatidylserine with these medications might increase the chance of side effects.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
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Per 5 mL (Peppermint):
Practitioner product
Per 5 mL (Peppermint):
- Lecithin 1.5 g equiv. phosphatidylcholine 520 mg
- Phosphatidylserine enriched soy (liquid) (Lecithin) 750 mg equiv. phosphatidylserine 150 mg
- Total Omega 3 2.3 g
- Eicosapentaenoic acid (EPA) 346 mg
- Docosahexaenoic acid (DHA) 1.2 g
- Cholecalciferol 12.5 μg equiv. vitamin D3 500 IU
- Tocotrienols complex - palm (Vitamin E) 160 mg
Practitioner product
Practitioner product
Per tablet:
- Phosphatidylserine enriched soy (powder) (Lecithin) 141.43 mg equiv. phosphatidylserine 100 mg
- L-ornithine monohydrochloride 255.07 mg equiv. ornithine 200 mg
- L-tyrosine 100 mg
- Calcium pantothenate (Vitamin B5) 75 mg equiv. pantothenic acid 68.71 mg equiv. calcium 6.29 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 25 mg equiv. pyridoxine 15.95 mg
Practitioner product
Per capsule:
Practitioner product
Per 6 g:
- Lecithin 100 mg equiv. phosphatidylcholine 20 mg
- Acetyl levocarnitine hydrochloride (Acetyl-L-carnitine) 250 mg
- Inositol 500 mg
- Choline bitartrate 350 mg equiv. choline 144 mg
- Pinus radiata ext. 50 mg
- Glycine 2 g
- Taurine 500 mg
- Calcium citrate 415 mg equiv. calcium 100 mg
- Potassium citrate 207 mg equiv. potassium 75 mg
- Magnesium citrate 842 mg equiv. magnesium 130 mg
- Zinc citrate dihydrate 31 mg equiv. zinc 10 mg
- Molybdenum trioxide 33 μg equiv. molybdenum 22.2 μg
- Selenomethionine 74.4 μg equiv. selenium 30 μg
- Pyridoxal 5-phosphate monohydrate (P5P) 15.7 mg equiv. pyridoxine 10 mg
- Nicotinamide (Vitamin B3) 15 mg
- Menaquinone 7 (Vitamin K2) 34.8 μg
- Hydroxocobalamin (Vitamin B12) 200 μg
- Calcium pantothenate (Vitamin B5) 20 mg equiv. pantothenic acid 18.3 mg
- Cholecalciferol (Vitamin D3) 24.6 μg equiv. vitamin D 1000 IU
- Calcium folinate (Activated folate) 217 μg equiv. folinic acid 200 μg
- Retinol acetate (Vitamin A) 461 μg equiv. vitamin A 400 μgRE equiv. vitamin A 1335 IU
- Riboflavin 5-phosphate sodium (Activated B2) 6.54 mg equiv. riboflavin 4.98 mg
- Punica granatum ext. 8.04 mg
- Vaccinium myrtillus ext. 2.5 mg
- Thiamine hydrochloride (Vitamin B1) 12.7 mg equiv. thiamine 10 mg
Practitioner product
Per tablet:
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Per tablet:
Practitioner product
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Per 10 g:
- Lecithin 725 mg
- Arthrospira platensis (Spirulina) 1 g
- Chlorella pyrenoidosa powder 333 mg
- Wheatgrass powder 333 mg
- Inulin (Dietary fibre) 800 mg
- Lactobacillus acidophilus 5 billion CFU
- Bifidobacterium bifidum 3 billion CFU
- Bifidobacterium lactis 5 billion CFU
- Bifidobacterium longum 1 billion CFU
- Cynara scolymus powder 500 mg
- Hordeum vulgare 200 mg
- Malus (Apple) 200 mg
- Brassica oleracea var. acephala (leaf & sprout) powder (Kale) 100 mg
- Ananas comosus (Pineapple) 240 mg
- Spinacia oleracea (Spinach) 67 mg
- Beta glucan 50 mg
- Resveratrol 10 mg
- Ananas comosus (Pineapple oil) 65 mg
- Linum usitatissimum (seed) (Flaxseed) 400 mg
- Oryza sativa (Rice bran) 500 mg
- Pea protein isolate 1 g
- R-alpha lipoic acid 67 mg
- Thiamine hydrochloride (Vitamin B1) 400 µg
- Niacinamide (Vitamin B3) 5.3 mg
- Pyridoxine hydrochloride (Vitamin B6) 567 µg
- Riboflavin (Vitamin B2) 434 µg
- Pantothenic acid (Vitamin B5) 1.7 mg
- Cyanocobalamin (Vitamin B12) 0.8 µg
- Ergocalciferol (Vitamin D) 3.8 µg
- Ascorbic acid (Vitamin C) 333 mg
- d-alpha-Tocopheryl acid succinate 100 mg
- Ubidecarenone (Coenzyme Q10) 8 mg
- Copper gluconate 225 µg
- Potassium phosphate dibasic 104 mg
- Folic acid 67 µg
- Biotin 10 µg
- Silica - colloidal anhydrous 14 mg
- Magnesium citrate 42 mg
- Zinc amino acid chelate 10 mg
- Chromium picolinate 10 µg
- Calcium citrate 132 mg
- Manganese amino acid chelate 1.4 mg
- Selenomethionine 30 µg
- Beta-carotene carotenoids (Vitamin A) 1.7 mg
- Citrus bioflavonoids extract 500 mg
- Citric acid anhydrous 150 mg
- Rosmarinus officinalis powder 68 mg
- Taraxacum officinale ext. 33 mg
- Vaccinium myrtillus powder 200 mg
- Glycyrrhiza glabra powder 67 mg
- Crataegus monogyna ext. 29 mg
- Astragalus membranaceus ext. 67 mg
- Vitis vinifera ext. 67 mg
- Camellia sinensis ext. 67 mg
- Ganoderma lucidum powder 21 mg
- Lentinula edodes powder 21 mg
- Aloe barbadensis ext. 500 mg
- Zingiber officinale powder 67 mg
- Eleutherococcus senticosus ext. 1 g
- Centella asiatica ext. 67 mg
- Withania somnifera ext. 67 mg
- Silybum marianum ext. 67 mg
- Arctium lappa ext. 21 mg
- Rosa canina powder 168 mg
- Lycium barbarum 33 mg
- Beta vulgaris (root) powder (Beetroot) 167 mg
- Daucus carota powder (Carrot) 83 mg
- Carica papaya (Papain) 250 mg
- Laminaria digitara (Kelp) 8 mg
- Natural vanilla flavour
- Natural pineapple flavour
- Thaumatin
- Stevia rebaubiana
- Luo Han Guo (fruit) ext. (Monk fruit)
- Xanthan gum
- Brassica oleracea var. italica powder 150 mg
- Malpighia glabra ext. 267 mg
- Theobroma cacao powder 100 mg
1 kg
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Per 37 g:
- Sunflower lecithin 250 mg
- Glutamine 2.22 g
- L-leucine 1.68 g
- Lysine hydrochloride 451.03 mg equiv. lysine 361 mg
- L-isoleucine 450 mg
- L-valine 450 mg
- L-phenylalanine 200 mg
- L-threonine 200 mg
- Cysteine hydrochloride 45 mg equiv. cysteine 31.04 mg
- L-methionine 120 mg
- L-tyrosine 112.5 mg
- Histidine hydrochloride 185.25 mg equiv. l-histidine 150 mg
- L-aspartic acid 111 mg
- L-proline 111 mg
- L-serine 27.75 mg
- Glycine 27.75 mg
- L-alanine 27.75 mg
- Taurine 11 mg
- Levocarnitine tartrate (L-carnitine) 10.99 mg equiv. levocarnitine 7.5 mg
- Potassium citrate 402.6 mg equiv. potassium 145.74 mg
- Magnesium citrate 167.09 mg equiv. magnesium 27 mg
- Magnesium glycerophosphate 49.99 mg equiv. magnesium 6.25 mg
- Calcium phosphate 62.64 mg equiv. calcium 25 mg
- Calcium glycerophosphate 393.27 mg equiv. calcium 75 mg
- Ferrous fumarate 45.6 mg equiv. iron 1.5 mg
- Manganese sulphate monohydrate 1.02 g equiv. manganese 330 µg
- Zinc sulphate monohydrate 5.74 mg equiv. zinc 2.08 mg
- Selenomethionine 28.64 µg equiv. selenium 11.54 µg
- Copper sulfate pentahydrate 656.27 µg equiv. copper 167 µg
- Molybdenum trioxide 12 µg equiv. molybdenum 8 µg
- Chromic chloride hexahydrate 46.95 µg equiv. chromium 9.16 µg
- Chromium picolinate 30.89 µg equiv. chromium 3.84 µg
- Potassium iodide 22.25 µg equiv. iodine 17 µg
- Borax 2.2 mg equiv. boron 250 µg
- Choline bitartrate 80.84 mg equiv. choline 33.25 mg
- Sodium ascorbate (Vitamin C) 22.5 mg equiv. ascorbic acid 20 mg
- dl-alpha-Tocopheryl acetate 10 mg equiv. vitamin E 10 IU
- Nicotinamide (Vitamin B3) 3.25 mg
- Retinol palmitate 418.58 µg equiv. vitamin A 767 IU
- Pyridoxine hydrochloride (Vitamin B6) 790 µg equiv. pyridoxine 650 µg
- Cholecalciferol 1.65 µg equiv. vitamin D3 66 IU
- Riboflavin (Vitamin B2) 500 µg
- Thiamine nitrate (Vitamin B1) 616.83 µg equiv. thiamine 500 µg
- Folic acid 31.27 µg
- Biotin 50 µg
- Calcium pantothenate (Vitamin B5) 3.53 mg equiv. pantothenic acid 3.25 mg
- Phytomenadione (Vitamin K1) 10 µg
- Cyanocobalamin (Vitamin B12) 2 µg
- Glucose monohydrate (Dextrose) 12.5 g
- Levomefolate glucosamine (Activated folate) 8 µg equiv. levomefolic acid 4.5 µg
- Medium Chain Triglycerides (powder) (MCT) 3 g
Practitioner product
Per 1 g:
- Sunflower lecithin 200 mg
- Acacia sp. (gum) 370 mg equiv. silicon 10.4 mg
- Glycine 430 mg
- Silica - colloidal anhydrous 4.63 mg
Practitioner product
Per 500 mg:
- Sunflower lecithin 185.6 mg
- Palmitoylethanolamide (PEA) 300 mg
- Thaumatin 1.9 mg
- Natural lemon lime flavour 12.5 mg
Practitioner product
Practitioner product
Per tablet:
- Lecithin 100 mg
- Glucosamine sulphate potassium chloride 663 mg equiv. glucosamine sulphate 500 mg equiv. potassium chloride 163 mg
- Cholecalciferol 2.5 µg equiv. vitamin D3 100 IU
- Boswellia serrata ext. 57.1 mg
- Nicotinamide (Vitamin B3) 200 mg
- Sodium ascorbate (Vitamin C) 112.5 mg equiv. ascorbic acid 100 mg
- Magnesium orotate dihydrate 103.58 mg equiv. magnesium 6.7 mg
- Manganese amino acid chelate 25 mg equiv. manganese 5 mg
- Silybum marianum ext. 5 mg
- Vitis vinifera ext. 1 mg
- Curcuma longa ext. 4 mg
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Practitioner product
Per tablet:
- Lecithin 50 mg
- Thiamine hydrochloride (Vitamin B1) 56 mg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 41 mg
- Riboflavin (Vitamin B2) 30 mg
- Cyanocobalamin (Vitamin B12) 400 μg
- Nicotinamide (Vitamin B3) 220 mg
- Calcium pantothenate (Vitamin B5) 105 mg
- Taurine 125 mg
- L-glutamine 100 mg
- Ascorbic acid (Vitamin C) 75 mg
- Potassium phosphate dibasic 71 mg equiv. potassium 32 mg
- Choline bitartrate 50 mg
- L-lysine 50 mg
- Calcium hydrogen phosphate dihydrate 52 mg equiv. calcium 12 mg
- Magnesium citrate 44 mg equiv. magnesium 7.1 mg
- Zinc sulphate monohydrate 41 mg equiv. zinc 15 mg
- Tocopherols concentrate - mixed (low-alpha type) (Vitamin E) 15 mg
- Borax 4.4 mg equiv. boron 500 μg
- Chromium nicotinate 500 μg equiv. chromium 50 μg
- Folic acid 395 μg
- Selenomethionine 62.5 μg equiv. selenium 25 μg
- Manganese amino acid chelate 113 μg equiv. manganese 18 μg
- Biotin 50 μg
- Potassium iodide (Iodine) 45.8 μg equiv. iodine 35 μg equiv. potassium 11 μg
- Copper gluconate 43 μg equiv. copper 6 μg
- Cholecalciferol 1 μg
- Iron bisglycinate 50 mg equiv. iron 10 mg
- Beta-carotene 5 mg
Practitioner product
Per tablet:
- Lecithin 50 mg
- Thiamine hydrochloride (Vitamin B1) 50 mg equiv. thiamine 44.59 mg
- Riboflavin (Vitamin B2) 20 mg
- Nicotinic acid (Vitamin B3) 5 mg
- Nicotinamide (Vitamin B3) 220 mg
- Calcium pantothenate (Vitamin B5) 100 mg equiv. pantothenic acid 91.61 mg equiv. calcium 8.39 mg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 41.14 mg
- Cyanocobalamin (Vitamin B12) 100 μg
- Retinol acetate 884.62 μg equiv. vitamin A 750 μg RE
- Folic acid 150 μg
- Ascorbic acid (Vitamin C) 50 mg
- Cholecalciferol 2.5 μg equiv. vitamin D3 100 IU
- d-alpha-Tocopheryl acid succinate 50 mg equiv. vitamin E 60.5 IU
- Biotin 50 μg
- Choline bitartrate 50 mg equiv. choline 20.56 mg
- L-glutamine 50 mg
- Inositol 25 mg
- Lysine hydrochloride 50 mg equiv. lysine 40 mg
- Taurine 125 mg
- Calcium hydrogen phosphate dihydrate 50 mg equiv. calcium 11.62 mg
- Chromic chloride hexahydrate 20.5 μg equiv. chromium 4 μg
- Potassium iodide (Iodine) 40.5 μg equiv. iodine 31 μg equiv. potassium 9.54 μg
- Manganese sulphate monohydrate 500 μg equiv. manganese 162.5 μg
- Magnesium phosphate pentahydrate 33.88 mg equiv. magnesium 7 mg
- Magnesium aspartate dihydrate 10.67 mg equiv. magnesium 800 μg
- Molybdenum trioxide 69.9 μg equiv. molybdenum 46.6 μg
- Potassium phosphate tribasic 30 mg equiv. potassium 14 mg
- Potassium aspartate 13.82 mg equiv. potassium 3 mg
- Zinc gluconate 110.26 mg equiv. zinc 14.4 mg
- Beta-carotene carotenoids (Vitamin A) 6 mg
- Copper sulfate pentahydrate 23.6 μg equiv. copper 6 μg
Practitioner product
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This monograph was last reviewed on 12/04/2024 10:00:00 and last updated on 02/09/2020 22:03:25. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
