Podophyllum
Scientific names: Podophyllum hexandrum, Podophyllum emodi, Sinopodophyllum emodi, Podophyllum peltatum
Family: Berberidaceae
Alternate names: American Mandrake, Citron Sauvage, Citronnier, Devil's Apple, Duck's Foot, Ground Lemon, Himalayan Mayapple, Hog Apple, Indian Apple, Indian Podophyllum, Ipécacuanha de la Caroline, Mandrake, Mayapple, Pa Giao Lian, Pied de Canard, Podófilo, Podophylli Pelati Rhizoma/Resina, Podophylle, Podophylle en Bouclier, Podophylle à Feuilles Peltées, Podophylle Indien, Podophylle Pelté, Podophyllin, Podophylline, Pomme de Mai, Raccoon Berry, Umbrella Plant, Vegetable Calomel, Vegetable Mercury, Wild Lemon, Wild Mandrake
Actions: Antibacterial, Anti-inflammatory, Antioxidant, Apoptosis, Cytotoxic, Radioprotective
Background
Podophyllum (Podophyllum hexandrum) is a plant. The entire plant is poisonous except for the ripe fruit. The plant resin (podophyllin) is used on the skin.
The podophyllum resin comes from the plant rhizome (root). It contains antioxidants and also toxic chemicals.
People use the podophyllum resin (podophyllin) for the removal of warts, including plantar warts and genital warts, and corns. It is also used for white patches on the tongue in people with weakened immune systems (hairy leukoplakia), and other conditions, but there is no good scientific evidence to support these other uses.
Don't confuse podophyllum with European mandrake or bryonia. These are not the same.
The podophyllum resin comes from the plant rhizome (root). It contains antioxidants and also toxic chemicals.
People use the podophyllum resin (podophyllin) for the removal of warts, including plantar warts and genital warts, and corns. It is also used for white patches on the tongue in people with weakened immune systems (hairy leukoplakia), and other conditions, but there is no good scientific evidence to support these other uses.
Don't confuse podophyllum with European mandrake or bryonia. These are not the same.
Safety Safety definitions
When taken by mouth: Podophyllum is likely unsafe. It is poisonous and may cause serious side effects, including death.
When applied to the skin: Podophyllum resin (podophyllin) is possibly safe when used short-term. But it is likely unsafe when applied in high doses, to large areas, or to damaged skin. Applying it to broken skin can lead to poisoning. Podophyllotoxin (podofilox, Condylox), a chemical found in podophyllum, is less toxic and seems to work better than podophyllum resin, so it's often used instead.
When applied to the skin: Podophyllum resin (podophyllin) is possibly safe when used short-term. But it is likely unsafe when applied in high doses, to large areas, or to damaged skin. Applying it to broken skin can lead to poisoning. Podophyllotoxin (podofilox, Condylox), a chemical found in podophyllum, is less toxic and seems to work better than podophyllum resin, so it's often used instead.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Podophyllum is likely unsafe when taken by mouth or applied to the skin while pregnant or breast-feeding. There have been reports of death and multiple birth defects. Avoid use.Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
- A sexually transmitted infection that can lead to genital warts or cancer (human papillomavirus or HPV). Applying podophyllum resin (podophyllin) to the skin is effective for removing genital warts.
Dosing & administration
There isn't enough reliable information to know what an appropriate dose of podophyllum might be. Taking podophyllum by mouth is unsafe and can lead to poisoning. Speak with a healthcare provider before applying any podophyllum products to the skin.
Interactions with pharmaceuticals
It is not known if Podophyllum interacts with any medicines. Before taking Podophyllum, talk with your healthcare professional if you take any medications.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
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Per serve:
- Podophyllum peltatum
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- Lycopodium clavatum (Clubmoss)
- Kalium carbonicum
- Argentum nitricum
- Acidum phosphoricum
- Magnesium phosphate (Mag phos)
- Natrium sulphuricum (Nat sulph)
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This monograph was last reviewed on 12/04/2024 10:00:00 and last updated on 23/10/2022 07:33:20. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
