Proteolytic enzymes (proteases)
Alternate names: Acidic Protease, Alkaline Protease, Aspergillopepsin, Dipeptidylpeptidase, DPP-IV, Endopeptidase, Exopeptidase, Neutral Protease, Pancreatic Proteinases, Pepsin, Peptidase, Protease I, Protease II, Protease 3.0, Protease 4.5, Protease 6.0, Proteinase
Actions: General, Anti-inflammatory, Immune, Wound healing
Background
Proteolytic enzymes (proteases) are enzymes that break down protein. These enzymes are made by animals, plants, fungi, and bacteria.
Proteolytic enzymes break down proteins in the body or on the skin. This might help with digestion or with the breakdown of proteins involved in swelling and pain. Some proteolytic enzymes that may be found in supplements include bromelain, chymotrypsin, ficin, papain, serrapeptase, and trypsin.
Proteolytic enzymes are used for a long list of conditions including cleaning wounds on the skin, help with digestion, pain and swelling, and many other conditions. Refer to specific topics for more information on uses and effects.
Proteolytic enzymes break down proteins in the body or on the skin. This might help with digestion or with the breakdown of proteins involved in swelling and pain. Some proteolytic enzymes that may be found in supplements include bromelain, chymotrypsin, ficin, papain, serrapeptase, and trypsin.
Proteolytic enzymes are used for a long list of conditions including cleaning wounds on the skin, help with digestion, pain and swelling, and many other conditions. Refer to specific topics for more information on uses and effects.
Safety Safety definitions
When taken by mouth: Proteolytic enzymes are possibly safe when taken appropriately. Side effects are usually mild or moderate and include stomach and intestinal complaints. See specific proteolytic enzymes for more detailed safety information.
When applied to the skin: Proteolytic enzymes are possibly safe when applied to the skin. Some may cause allergic reactions. See specific proteolytic enzymes for more detailed safety information.
When applied to the skin: Proteolytic enzymes are possibly safe when applied to the skin. Some may cause allergic reactions. See specific proteolytic enzymes for more detailed safety information.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if proteolytic enzymes are safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Effectiveness
Effective Effectiveness definitions
Proteolytic enzymes represent a large group of enzymes. See specific proteolytic enzymes for effectiveness information.
Dosing & administration
See specific proteolytic enzymes for dosing information.
Interactions with pharmaceuticals
See specific proteolytic enzymes for interactions with medicines.
Interactions with herbs & supplements
See specific proteolytic enzymes for interactions with herbs and supplements.
Interactions with foods
See specific proteolytic enzymes for interactions with foods.
Products
View all products
Per capsule:
- Aspergillus oryzae 190 mg equiv. protease 60000 HUT
- Trichoderma longibrachiatum (Trichoderma fungus) 5.5 mg equiv. cellulase 1000 CU
- Rhizopus oryzae (Microfungus) 4.6 mg equiv. lipase 500 LipU
- Punica granatum ext. 62.5 mg
- Cinnamomum verum ext. 50 mg
Practitioner product
Per tablet:
Practitioner product
Practitioner product
Practitioner product
Per capsule:
- Protease 60000 HUT
- Amylase enzyme 10000 DUAA
- Lipase 400 LipU
- Tilactase 1500 ALU
- Cellulase 125 CU
- Ananas comosus (Bromelain) 1500000 PU
- Gentiana lutea ext. 120 mg
RRP: $50.50$35.35Save: 30%
Create account
Per capsule:
- Protease 31250 HUT
- Amylase enzyme 10000 DUAA
- Lipase 40 LipU
- Cellulase 4000 CU
Practitioner product
Per capsule:
Practitioner product
Per capsule:
- Protease 4.5 30000 HUT
- Amylase enzyme 10000 DU
- Lipase 500 FCC LU
- Lactase 1500 ALU
- Glucoamylase 60 AGU
- Cellulase 1000 CU
- Invertase 500 SU
Practitioner product
Per capsule:
- Protease 30000 HUT
- Tilactase 1500 ALU
- Amylase enzyme 12000 DU
- Cellulase 1000 CU
- Lipase 500 LipU
Practitioner product
Per capsule:
- Protease 24500 HUT
- Amylase enzyme 3500 DU
- Lipase 250 LipU
- Cellulase 350 CU
- Beta-D-galactosidase (Tilactase) 2250 ALU
Practitioner product
Per capsule:
- Protease 10800 HUT
- Amylase enzyme 4500 DUAA
- Lipase 100 LipU
- Beta-D-galactosidase (Tilactase) 500 ALU
- Cellulase 80 CU
Practitioner product
Per capsule:
Practitioner product
Practitioner product
RRP: $54.95$46.71Save: 15%
Create account
Per 5 g (Cucumber Lime):
- Protease 1000 DU
- Brassica oleracea var. italica powder 250 mg
- Arthrospira platensis (Spirulina) 100 mg
- Cordyceps sinensis 105 mg
- Lentinula edodes 100 mg
- Trametes versicolor 70 mg
- Astragalus membranaceus 100 mg
- Camellia sinensis 500 mg
- Grifola frondosa 125 mg
- Spinacia oleracea (Spinach) 175 mg
- Brassica oleracea var. acephala (leaf) powder (Kale) 175 mg
- Nasturtium officinale 160 mg
- Apium graveolens powder 110 mg
- Pleurotus eryngii 100 mg
- Lipase 750 LipU
- Ananas comosus (Bromelain) 350 GDU
- Carica papaya (Papain) 40 mg
- L-glutamine 500 mg
- Bacillus coagulans 4 billion CFU
- Lactobacillus rhamnosus 750 million CFU
- Saccharomyces cerevisiae (boulardii) (SB) 500 million CFU
- Quercetin 100 mg
- Taraxacum officinale 100 mg
- Coriandrum sativum 80 mg
- Zingiber officinale 50 mg
- Rosmarinus officinalis 50 mg
- Origanum vulgare powder 50 mg
- Natural flavours
- Stevia rebaubiana ext.
- Eleutherococcus senticosus 100 mg
- Citric acid anhydrous
- Chlorella vulgaris powder 175 mg
150 g Cucumber Lime
RRP: $59.95$53.96Save: 10%
Create account
Per 30 g (Choc Sea Salt):
- Protease 960 µg
- Pea protein isolate
- Pumpkin powder
- Citrullus lanatus (Watermelon)
- Cannabis sativa (seed) powder
- Schizochytrium sp. (Chromista algae oil)
- d-alpha-Tocopherol
- Medium Chain Triglycerides (powder) (MCT)
- Amylase enzyme 3840 µg
- Lactase 640 µg
- Lipase 160 µg
- Cellulase 32 µg
- Flavour
- Pink Himalayan crystal salt
- Theobroma cacao
- Stevia rebaubiana
900 g Choc Sea Salt
RRP: $74.95$67.45Save: 10%
Create account
Per 5 g:
- Protease
- Inulin (Dietary fibre)
- Marine collagen peptides 250 mg
- Lepidium meyenii (root) powder
- Lactobacillus rhamnosus (LR-32)
- Bifidobacterium longum (BL-05)
- Zinc
- Cannabis sativa powder 520 mg
- Arthrospira platensis (Spirulina) 370 mg
- Linum usitatissimum (seed) flour (Flaxseed) 250 mg
- Wheatgrass powder
- Sunflower lecithin
- Citrus limon (juice) (Lemon)
- Ananas comosus (Pineapple)
- Ascorbic acid (Vitamin C)
- Euterpe oleracea (berry) ext. (Acai)
- Chlorella pyrenoidosa powder
- Lycopersicon esculentum (Tomato)
- Apple pectin
- Beta vulgaris (root) powder (Beetroot)
- Citric acid anhydrous
- Citrullus lanatus (Watermelon)
- Fragaria ananassa (juice) powder (Strawberry)
- Garcinia mangostana (fruit) powder
- Punica granatum juice dry
- Carica papaya (fruit) powder
- Vaccinium macrocarpon (fruit) powder
- Natural vanilla flavour
- Lycium barbarum (fruit)
- Aristotelia chilensis (Maqui berry)
- Silybum marianum powder
- Astragalus membranaceus (root) powder
- Equisetum arvense (herb) powder
- Laminaria digitara (Kelp)
- Silica - colloidal anhydrous
- Daucus carota powder (Carrot)
- Camellia sinensis powder
- Withania somnifera (root) powder
- Eleutherococcus senticosus (root) powder
- Echinacea purpurea (root) powder
- Melissa officinalis powder
- Taraxacum officinale (leaf) powder
- Zingiber officinale (root) powder
- Rosa canina powder
- Vaccinium myrtillus (fruit) powder
- Ulmus rubra (bark) powder
- Mushroom powder
- Kakadu plum powder
- Calcium pantothenate (Vitamin B5)
- Panax ginseng powder
- Curcuma longa (root) powder
- Backhousia citriodora (leaf)
- Thaumatin
- Ananas comosus (Bromelain)
- Phyllanthus emblica (fruit) powder
- Morindae officinalis (fruit) powder
- Marine algae
- Malpighia glabra (fruit) powder
- Medicago sativa 200 mg
- Sambucus nigra (fruit)
- Vaccinium corymbosum (fruit) powder
- Hordeum vulgare powder 200 mg
- Salvia hispanica (seed) powder
RRP: $39.95$33.96Save: 15%
Create account
Per 10 g:
- Protease
- Pea protein isolate
- Malus (Apple)
- Apple pectin
- Arthrospira platensis (Spirulina)
- Linum usitatissimum (seed) (Flaxseed)
- Sunflower lecithin
- Marine algae
- Wheatgrass powder
- Beta vulgaris (root) powder (Beetroot)
- Brassica oleracea var. italica (Broccoli)
- Chlorella pyrenoidosa powder
- Spinacia oleracea (Spinach)
- Daucus carota powder (Carrot)
- Zingiber officinale
- Glycyrrhiza glabra (root)
- Cynara scolymus
- Ribes nigrum
- Vitis vinifera
- Malpighia glabra
- Vaccinium myrtillus
- Camellia sinensis
- Rosa canina
- Centella asiatica
- Silybum marianum
- Rhodiola rosea
- Rosmarinus officinalis
- Withania somnifera
- Taraxacum officinale
- Lycium chinese (berry)
- Citric acid anhydrous
- Citrus bioflavonoids extract
- R,S-alpha lipoic acid
- Beta glucan
- Ubiquinol-10 (Coenzyme Q10)
- Dunaliella salina
- Lactobacillus acidophilus
- Bifidobacterium bifidum
- Potassium phosphate dibasic
- Magnesium citrate
- Ascorbic acid (Vitamin C)
- Natural vanilla flavour
- Natural pineapple flavour
- Zinc citrate
- Tocopherols concentrate - mixed (Vitamin E)
- Selenomethionine
- D-calcium pantothenate (Vitamin B5)
- Nicotinamide (Vitamin B3)
- Pyridoxine hydrochloride (Vitamin B6)
- Retinyl palmitate
- Cholecalciferol
- Copper gluconate
- Thiamine hydrochloride (Vitamin B1)
- Riboflavin (Vitamin B2)
- Folate
- Chromium picolinate
- Panax ginseng
- Fucus vesiculosus
- Stevia rebaubiana (leaf)
- Phytomenadione (Vitamin K1)
- Biotin
- Cyanocobalamin (Vitamin B12)
- Lentinula edodes (fruiting body)
- Ulmus rubra (bark inner) powder
- Hordeum vulgare
- Plantago ovata (husk) (Psyllium)
- Theobroma cacao
- Tocopherols concentrate - mixed (Vitamin E)
- Astragalus membranaceus
- Manganese gluconate
- Menaquinone 7 (Vitamin K2)
- Fallopia japonica
- Amylase enzyme
- Lipase
- Cellulase
- Lactase
- Euterpe oleracea (berry) ext. (Acai)
- Bacopa monnieri
- Salvia officinalis
- Vaccinium macrocarpon
RRP: $210.00$172.21Save: 18%
Create account
Per 9 g:
- Protease
- Chlorella pyrenoidosa powder
- Brassica oleracea var. acephala (leaf) powder (Kale)
- Inulin (Dietary fibre)
- Medicago sativa
- Brassica oleracea var. italica (Broccoli)
- Spinacia oleracea (Spinach)
- Green banana
- Bacillus coagulans (GBI-30)
- Arthrospira platensis (Spirulina)
- Laminaria digitara (Kelp)
- Euterpe oleracea (berry) ext. (Acai)
- Vaccinium corymbosum
- Malpighia glabra
- Beta vulgaris
- Punica granatum juice dry
- Lycium chinese
- Golden pea protein (sprout) bio-fermented
- Apple pectin
- Rubus idaeus (berry)
- Fragaria ananassa (Strawberry)
- Hippophae rhamnoides
- Lycopersicon esculentum
- Arctic sea algae
- Sea salt
- Sunflower seed extract
- Ananas comosus (Pineapple)
- Citrus limon (Lemon)
- Linum usitatissimum (seed) (Flaxseed)
- Malus (Apple)
- Lepidium meyenii
- Natural flavours
- Silybum marianum
- Equisetum arvense
- Centella asiatica
- Glycyrrhiza glabra (root)
- Althaea officinalis (root)
- Melissa officinalis
- Taraxacum officinale (leaf)
- Zingiber officinale (root)
- Withania somnifera
- Aloe barbadensis (leaf)
- Panax ginseng
- Pumpkin powder
- Sweet potato powder
- Sunflower seed
- Vaccinium macrocarpon
- Grifola frondosa (mushroom)
- Lentinula edodes (mushroom)
- Myrciaria dubia (fruit) powder (Camu Camu)
- Amylase enzyme
- Lipase
- Cellulase
- Lactase
- Mesquite (pod) powder
- Thaumatin
- Prunus salicina (Queen Garnet plum)
- Chlorella pyrenoidosa powder
RRP: $134.95$112.00Save: 17%
Create account
Per 6 g:
- Aspergillus oryzae (Kōji mould)
- Fermented soybean paste (Red miso)
- Oryza sativa (Rice)
- Sea salt
- Medium Chain Triglycerides (powder) (MCT)
- Nutritional yeast flakes (Dried yeast)
- Pink Himalayan crystal salt
- Tapioca
- Allium cepa
- Daucus carota powder (Carrot)
- Apium graveolens
- Oryza sativa (Brown rice)
- Allium sativum
- Curcuma longa
- Pumpkin powder
- Brassica oleracea var. acephala (leaf) powder (Kale)
- Spinacia oleracea (Spinach)
- Sweet potato powder
- Brassica oleracea var. italica (Broccoli)
- Laminaria digitara (Kelp)
- Petroselinum crispum
- Allium schoenoprasum
- Piper nigrum
- Arctic sea algae
RRP: $24.95$20.71Save: 17%
Create account
vital.ly has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 17/10/2023 11:00:00 and last updated on 22/07/2020 01:02:03. Monographs are reviewed and/or updated multiple times per month and at least once per year.
Natural Medicines disclaims any responsibility related to medical consequences of using any medical product. Effort is made to ensure that the information contained in this monograph is accurate at the time it was published. Consumers and medical professionals who consult this monograph are cautioned that any medical or product related decision is the sole responsibility of the consumer and/or the health care professional. A legal License Agreement sets limitations on downloading, storing, or printing content from this Database. No reproduction of this monograph or any content from this Database is permitted without written permission from the publisher. It is unlawful to download, store, or distribute content from this site.
Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
