Proteolytic enzymes (proteases)
Alternate names: Acidic Protease, Alkaline Protease, Aspergillopepsin, Dipeptidylpeptidase, DPP-IV, Endopeptidase, Exopeptidase, Neutral Protease, Pancreatic Proteinases, Pepsin, Peptidase, Protease I, Protease II, Protease 3.0, Protease 4.5, Protease 6.0, Proteinase
Actions: General, Anti-inflammatory, Immune, Wound healing
Background
Proteolytic enzymes (proteases) are enzymes that break down protein. These enzymes are made by animals, plants, fungi, and bacteria.
Proteolytic enzymes break down proteins in the body or on the skin. This might help with digestion or with the breakdown of proteins involved in swelling and pain. Some proteolytic enzymes that may be found in supplements include bromelain, chymotrypsin, ficin, papain, serrapeptase, and trypsin.
Proteolytic enzymes are used for a long list of conditions including cleaning wounds on the skin, help with digestion, pain and swelling, and many other conditions. Refer to specific topics for more information on uses and effects.
Proteolytic enzymes break down proteins in the body or on the skin. This might help with digestion or with the breakdown of proteins involved in swelling and pain. Some proteolytic enzymes that may be found in supplements include bromelain, chymotrypsin, ficin, papain, serrapeptase, and trypsin.
Proteolytic enzymes are used for a long list of conditions including cleaning wounds on the skin, help with digestion, pain and swelling, and many other conditions. Refer to specific topics for more information on uses and effects.
Safety Safety definitions
When taken by mouth: Proteolytic enzymes are possibly safe when taken appropriately. Side effects are usually mild or moderate and include stomach and intestinal complaints. See specific proteolytic enzymes for more detailed safety information.
When applied to the skin: Proteolytic enzymes are possibly safe when applied to the skin. Some may cause allergic reactions. See specific proteolytic enzymes for more detailed safety information.
When applied to the skin: Proteolytic enzymes are possibly safe when applied to the skin. Some may cause allergic reactions. See specific proteolytic enzymes for more detailed safety information.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if proteolytic enzymes are safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Effectiveness
Effective Effectiveness definitions
Proteolytic enzymes represent a large group of enzymes. See specific proteolytic enzymes for effectiveness information.
Dosing & administration
See specific proteolytic enzymes for dosing information.
Interactions with pharmaceuticals
See specific proteolytic enzymes for interactions with medicines.
Interactions with herbs & supplements
See specific proteolytic enzymes for interactions with herbs and supplements.
Interactions with foods
See specific proteolytic enzymes for interactions with foods.
Products
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Per capsule:
- Aspergillus oryzae (Kōji mould) 4.75 mg equiv. protease 3709 HUT
- Aspergillus oryzae (Kōji mould) 5.7 mg equiv. amylase 750 DUAA
- Ananas comosus (Bromelain) 217800 PU
- Carica papaya (Papain) 235200 PU
- Rhizopus oryzae (Microfungus) 9.4 mg equiv. lipase 525 LipU
- Lactobacillus acidophilus (MED 27 & MED 28) 5 billion CFU
- Lactobacillus rhamnosus (MED 26) 2.5 billion CFU
- Bifidobacterium bifidum (MED 11) 125 million CFU
- Bifidobacterium animalis ssp. lactis (MED 13) 1.125 billion CFU
Practitioner product
Per capsule:
- Aspergillus oryzae 190 mg equiv. protease 60000 HUT
- Trichoderma longibrachiatum (Trichoderma fungus) 5.5 mg equiv. cellulase 1000 CU
- Rhizopus oryzae (Microfungus) 4.6 mg equiv. lipase 500 LipU
- Punica granatum ext. 62.5 mg
- Cinnamomum verum ext. 50 mg
Practitioner product
Per tablet:
Practitioner product
Practitioner product
Practitioner product
Per capsule:
- Protease 80000 HUT
- Perilla frutescens ext. 75 mg
- Amylase enzyme 24000 DU
- Lipase 25000 LipU
- Tilactase 15000 ALU
- Cellulase 1000 CU
Practitioner product
Per capsule:
- Protease 70000 HUT
- Amylase enzyme 23000 DU
- Lipase 2000 LipU
- Cellulase 1000 CU
- Beta-D-galactosidase (Tilactase) 900 ALU
Practitioner product
Per capsule:
- Protease 60000 HUT
- Amylase enzyme 10000 DUAA
- Lipase 400 LipU
- Tilactase 1500 ALU
- Cellulase 125 CU
- Ananas comosus (Bromelain) 1500000 PU
- Gentiana lutea ext. 120 mg
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Practitioner product
Per capsule:
- Protease 31250 HUT
- Amylase enzyme 10000 DUAA
- Lipase 40 LipU
- Cellulase 4000 CU
Practitioner product
Per capsule:
Practitioner product
Per capsule:
- Protease 4.5 30000 HUT
- Amylase enzyme 10000 DU
- Lipase 500 FCC LU
- Lactase 1500 ALU
- Glucoamylase 60 AGU
- Cellulase 1000 CU
- Invertase 500 SU
Practitioner product
Per capsule:
- Protease 30000 HUT
- Tilactase 1500 ALU
- Amylase enzyme 12000 DU
- Cellulase 1000 CU
- Lipase 500 LipU
Practitioner product
Per capsule:
- Protease 24500 HUT
- Amylase enzyme 3500 DU
- Lipase 250 LipU
- Cellulase 350 CU
- Beta-D-galactosidase (Tilactase) 2250 ALU
Practitioner product
Per capsule:
- Protease 10800 HUT
- Amylase enzyme 4500 DUAA
- Lipase 100 LipU
- Beta-D-galactosidase (Tilactase) 500 ALU
- Cellulase 80 CU
Practitioner product
Per capsule:
Practitioner product
Practitioner product
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Per 5 g (Cucumber Lime):
- Protease 1000 DU
- Brassica oleracea var. italica powder 250 mg
- Arthrospira platensis (Spirulina) 100 mg
- Cordyceps sinensis 105 mg
- Lentinula edodes 100 mg
- Trametes versicolor 70 mg
- Astragalus membranaceus 100 mg
- Camellia sinensis 500 mg
- Grifola frondosa 125 mg
- Spinacia oleracea (Spinach) 175 mg
- Brassica oleracea var. acephala (leaf) powder (Kale) 175 mg
- Nasturtium officinale 160 mg
- Apium graveolens powder 110 mg
- Pleurotus eryngii 100 mg
- Lipase 750 LipU
- Ananas comosus (Bromelain) 350 GDU
- Carica papaya (Papain) 40 mg
- L-glutamine 500 mg
- Bacillus coagulans 4 billion CFU
- Lactobacillus rhamnosus 750 million CFU
- Saccharomyces cerevisiae (boulardii) (SB) 500 million CFU
- Quercetin 100 mg
- Taraxacum officinale 100 mg
- Coriandrum sativum 80 mg
- Zingiber officinale 50 mg
- Rosmarinus officinalis 50 mg
- Origanum vulgare powder 50 mg
- Natural flavours
- Stevia rebaubiana ext.
- Eleutherococcus senticosus 100 mg
- Citric acid anhydrous
- Chlorella vulgaris powder 175 mg
150 g Cucumber Lime
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Per 30 g (Choc Sea Salt):
- Protease 960 µg
- Pea protein isolate
- Pumpkin powder
- Citrullus lanatus (Watermelon)
- Cannabis sativa (seed) powder
- Schizochytrium sp. (Chromista algae oil)
- d-alpha-Tocopherol
- Medium Chain Triglycerides (powder) (MCT)
- Amylase enzyme 3840 µg
- Lactase 640 µg
- Lipase 160 µg
- Cellulase 32 µg
- Flavour
- Pink Himalayan crystal salt
- Theobroma cacao
- Stevia rebaubiana
900 g Choc Sea Salt
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This monograph was last reviewed on 17/10/2023 11:00:00 and last updated on 22/07/2020 01:02:03. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
