Rhodiola
Scientific names: Rhodiola rosea, Sedum rhodiola, Sedum rosea
Family: Crassulaceae
Alternate names: Arctic Root, Extrait de Rhodiole, Golden Root, Hongjingtian, Hong Jing Tian, King's Crown, Lignum Rhodium, Orpin Rose, Racine d'Or, Racine Dorée, Racine de Rhadiola, Rhodiole, Rhodiole Rougeâtre, Rodia Riza, Rose Root, Rose Root Extract, Rosenroot, Roseroot, Rosewort, Siberian Golden Root, Siberian Rhodiola Rosea, Snowdown Rose
Actions: Adaptogenic, Antiaging, Antiarrhythmic, Antibacterial, Anticancer, Antidepressant, Antidiabetic, Antihypertensive effect, Antihypoxic, Anti-inflammatory, Antioxidant, Antiviral, Anxiolytic, Athletic performance enhancement, Cardioprotective, Central nervous system, Cognitive, CYP450 inhibitory, Hepatoprotective, Hypolipidemic, Immunomodulatory, Neuroprotective, P-glycoprotein inhibitory
Background
Rhodiola (Rhodiola rosea) is a plant that grows in cold parts of Europe and Asia. The root has a long history of use in traditional medicine.
Rhodiola is considered an adaptogen. Adaptogens are a class of natural substances that are believed to stimulate the body's resistance to physical, environmental, and emotional stressors. Rhodiola extract might help protect cells from damage and regulate heartbeat.
People use rhodiola for fatigue, anxiety, depression, stress, and many other conditions, but there is no good scientific evidence to support any of these uses.
Rhodiola is considered an adaptogen. Adaptogens are a class of natural substances that are believed to stimulate the body's resistance to physical, environmental, and emotional stressors. Rhodiola extract might help protect cells from damage and regulate heartbeat.
People use rhodiola for fatigue, anxiety, depression, stress, and many other conditions, but there is no good scientific evidence to support any of these uses.
Safety Safety definitions
When taken by mouth: Rhodiola is possibly safe when taken for 6-12 weeks. Rhodiola might cause dizziness, dry mouth, or excessive saliva. There isn't enough reliable information to know if rhodiola is safe to use long-term.
Autoimmune diseases: Rhodiola might stimulate the immune system. This might worsen autoimmune diseases, such as multiple sclerosis (MS), rheumatoid arthritis (RA), and others.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if rhodiola is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Autoimmune diseases: Rhodiola might stimulate the immune system. This might worsen autoimmune diseases, such as multiple sclerosis (MS), rheumatoid arthritis (RA), and others.
Effectiveness
Effective Effectiveness definitions
There is interest in using rhodiola for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Dosing & administration
Rhodiola has most often been used by adults in doses of 100-600 mg by mouth daily for up to 12 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Interactions with pharmaceuticals
Losartan (Cozaar)
Interaction Rating=Moderate Be cautious with this combination.
Rhodiola might change how the body breaks down losartan. Taking rhodiola along with losartan might increase the effects and side effects of losartan.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)
Interaction Rating=Minor Be watchful with this combination.
Some medications are changed and broken down by the liver. Rhodiola might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Rhodiola might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating=Minor Be watchful with this combination.
Some medications are changed and broken down by the liver. Rhodiola might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications for diabetes (Antidiabetes drugs)
Interaction Rating=Moderate Be cautious with this combination.
Rhodiola might lower blood sugar levels. Taking rhodiola along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating=Moderate Be cautious with this combination.
Rhodiola might lower blood pressure. Taking rhodiola along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Medications moved by pumps in cells (P-glycoprotein substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are moved in and out of cells by pumps. Rhodiola might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Medications that decrease the immune system (Immunosuppressants)
Interaction Rating=Moderate Be cautious with this combination.
Rhodiola can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking rhodiola along with these medications might decrease the effects of these medications.
Interactions with herbs & supplements
Herbs and supplements that might lower blood pressure: Rhodiola might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much. Examples of supplements with this effect include andrographis, casein peptides, L-arginine, niacin, and stinging nettle.
Herbs and supplements that might lower blood sugar: Rhodiola might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.
Herbs and supplements that might lower blood sugar: Rhodiola might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.
Interactions with foods
There are no known interactions with foods.
Products
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Per tablet:
- Rhodiola rosea (Rhodiola) ext. 93.75 mg equiv. rosavins 2.81 mg equiv. salidroside 940 μg
- Glycyrrhiza glabra ext. 58.8 mg
- Pyridoxal 5-phosphate (P5P) 3.76 mg equiv. pyridoxine 2.4 mg
- Eleutherococcus senticosus ext. 66.7 mg
- L-tyrosine 500 mg
- Selenomethionine 86.9 μg equiv. selenium 35 μg
- Alpinia galanga ext. 150 mg
Practitioner product
Per capsule:
- Rhodiola rosea (Rhodiola) ext. 81.25 mg equiv. rosavins 2.44 mg equiv. salidroside 813 μg
- Crocus sativus ext. 7.33 mg
- Withania somnifera ext. 160 mg
- Pyridoxine hydrochloride (Vitamin B6) 11 mg equiv. pyridoxine 9.05 mg
- Pyridoxal 5-phosphate (P5P) 5 mg equiv. pyridoxine 3.42 mg
- Ascorbic acid (Vitamin C) 35 mg
- Zinc citrate 26.2 mg equiv. zinc 8.5 mg
- Hypericum perforatum ext. 250 mg
Practitioner product
Practitioner product
Practitioner product
Per tablet:
- Rhodiola rosea (Rhodiola) ext. 250 mg
- Ascorbic acid (Vitamin C) 150 mg
- Folic acid 200 μg
- Cyanocobalamin (Vitamin B12) 200 μg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 41.14 mg
- Nicotinamide (Vitamin B3) 100 mg
- Calcium pantothenate (Vitamin B5) 100 mg
- Thiamine hydrochloride (Vitamin B1) 75 mg
- Riboflavin (Vitamin B2) 50 mg
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Per tablet:
- Rhodiola rosea (Rhodiola) ext. 75 mg
- Vitex agnus-castus ext. 100 mg
- Bupleurum falcatum ext. 150 mg
- Withania somnifera ext. 208.3 mg
- Tocopherols concentrate - mixed (low-alpha type) 75 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 23.5 mg equiv. pyridoxine 15 mg
- Zinc citrate dihydrate 46.58 mg equiv. zinc 15 mg
- Potassium iodide 194.9 µg equiv. iodine 149 µg
- Selenomethionine 187.5 µg equiv. selenium 75 µg
Practitioner product
Per capsule:
- Rhodiola rosea (Rhodiola) ext. 75 mg
- Crocus sativus ext. 14 mg
- Withania somnifera ext. 150 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 7.94 mg equiv. pyridoxine 5 mg
- Calcium folinate (Activated folate) 220 µg equiv. folinic acid 200 µg
- Mecobalamin (Vitamin B12) 100 µg
- Schisandra chinensis ext. 80 mg
- Thiamine hydrochloride (Vitamin B1) 25.42 mg equiv. thiamine 20 mg
- Riboflavin 5-phosphate sodium (Activated B2) 13.16 mg equiv. riboflavin 10 mg
- Nicotinamide (Vitamin B3) 50 mg
- Calcium pantothenate (Vitamin B5) 54.59 mg equiv. pantothenic acid 50 mg
- Ganoderma lucidum ext. 75 mg
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Per tablet:
- Rhodiola rosea (Rhodiola) ext. 36 mg
- Hypericum perforatum ext. 600 mg
- Withania somnifera ext. 60 mg
- Plectranthus barbatus ext. 17 mg
- S-Adenosylmethionine disulfate tosylate (SAMe) 98 mg equiv. s-Adenosylmethionine 50 mg
- Calcium folinate (Activated folate) 270 μg equiv. folinic acid 250 μg
- Potassium iodide 98 μg equiv. iodine 75 μg
- Cholecalciferol 5 μg equiv. vitamin D3 200 IU
- Selenomethionine 125 μg equiv. selenium 50 μg
Practitioner product
Per tablet:
- Rhodiola rosea (Rhodiola) ext. 25 mg
- L-tyrosine 500 mg
- Potassium iodide 200 μg equiv. iodine 150 μg
- Selenomethionine 190 μg equiv. selenium 75 μg
- Zinc citrate dihydrate 15.58 mg equiv. zinc 5 mg
- Withania somnifera ext. 150 mg
- Cholecalciferol 5 μg equiv. vitamin D3 200 IU
- d-alpha-Tocopheryl acid succinate 43 mg equiv. vitamin E 52 IU
- Ascorbic acid (Vitamin C) 100 mg
- Riboflavin 5-phosphate sodium (Activated B2) 13 mg equiv. riboflavin 10 mg
Practitioner product
Per 7 g (Tropical):
- Rhodiola rosea (Rhodiola) ext. 50 mg
- Ascorbic acid (Vitamin C) 38 mg
- Pyridoxine hydrochloride (Vitamin B6) 25 mg
- Magnesium diglycinate 3 g equiv. magnesium 300 mg
- Acetyl levocarnitine hydrochloride (Acetyl-L-carnitine) 1.2 g
- Nicotinamide (Vitamin B3) 50 mg
- Calcium pantothenate (Vitamin B5) 50 mg
- Thiamine hydrochloride (Vitamin B1) 38 mg
- Riboflavin (Vitamin B2) 25 mg
- Potassium iodide 98 µg equiv. iodine 75 µg
- Selenomethionine 125 µg equiv. selenium 50 µg
- Zinc diglycinate 50 mg equiv. zinc 10 mg
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This monograph was last reviewed on 04/07/2024 10:00:00 and last updated on 11/11/2020 23:52:54. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
