Tocotrienols
Scientific names: Alpha-Tocotrienol, Beta-TocotrienolDelta-TocotrienolGamma-Tocotrienol
Alternate names: 8-Methyltocotrienol, Alpha Tocotrienol, Alpha-Tocotriénol, Beta Tocotrienol, Bêta-Tocotriénol, Concentré de Tocotriénol, D-Alpha Tocotrienol, D-Alpha Tocotriénol, D-Gamma Tocotrienol, D-Gamma-Tocotriénol, Delta Tocotrienol, Delta-Tocotriénol, Epsilon-Tocopherol, Epsilon-Tokoferol, Epsilon Tocopherol, Gamma Tocotrienol, Gamma-Tocotriénol, Mixed Tocotrienols, Palm Tocotrienols, Rice Tocotrienols, Tocotrienol, Tocotriénol, Tocotrienol Concentrate, Tocotriénols, Tocotriénols de Palme, Tocotriénols de Riz, Tocotriénols Mixtes, Zeta1-Tocopherol
Actions: Antiaging, Anticancer, Antioxidant activity, Autonomic, Cardiovascular, CYP450, Hypolipidemic, Neuroprotective
Background
Vitamin E is an essential nutrient that includes both tocotrienols and tocopherols. Tocotrienols have double bonds and are found in palm and rice bran oil.
Tocotrienols exist in four different forms: alpha-, beta-, gamma-, and delta-tocotrienols. Tocotrienols seem to have many different effects in the body. They might lower cholesterol levels and provide heart health benefits.
People use tocotrienols for high cholesterol, cancer, stroke, aging, and many other conditions, but there is no good scientific evidence to support these uses.
To learn about tocopherols, another source of vitamin E, review vitamin E.
Tocotrienols exist in four different forms: alpha-, beta-, gamma-, and delta-tocotrienols. Tocotrienols seem to have many different effects in the body. They might lower cholesterol levels and provide heart health benefits.
People use tocotrienols for high cholesterol, cancer, stroke, aging, and many other conditions, but there is no good scientific evidence to support these uses.
To learn about tocopherols, another source of vitamin E, review vitamin E.
Safety Safety definitions
When taken by mouth: Tocotrienols are possibly safe when used at a dose of 200 mg daily for up to 5 years. They're usually well tolerated.
When applied to the skin: There isn't enough reliable information to know if tocotrienols are safe. Tocotrienol cream can cause mild itching in some people.
When applied to the skin: There isn't enough reliable information to know if tocotrienols are safe. Tocotrienol cream can cause mild itching in some people.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if tocotrienols are safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Diabetes. Taking tocotrienols by mouth may improve blood sugar in adults with type 2 diabetes.
Possibly ineffective Effectiveness definitions
- High cholesterol. Taking tocotrienols by mouth doesn't seem to improve cholesterol levels.
Dosing & administration
Tocotrienols have most often been used by adults in doses of 200-600 mg by mouth daily for up to 6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Interactions with pharmaceuticals
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Minor Be watchful with this combination.
Tocotrienols might slow blood clotting. Taking tocotrienols along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
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Per 3.1 g (Lime):
- d-alpha-Tocopheryl acid succinate 200 mg equiv. vitamin E 242 IU
- Quercetin dihydrate 447.7 mg equiv. quercetin 400 mg
- Rutin (Rutoside) 500 mg
- Ananas comosus (Bromelain) 1.5 million PU
- Magnesium ascorbate monohydrate (Vitamin C) 952.7 mg equiv. ascorbic acid 850 mg
- Zinc gluconate 27.93 mg equiv. zinc 4 mg
- Calcium pantothenate (Vitamin B5) 109 mg equiv. pantothenic acid 99.9 mg
- Selenomethionine 32.24 μg equiv. selenium 13 μg
- Retinol acetate (Vitamin A) 0.884 mg equiv. vitamin A 750 μgRE equiv. vitamin A 2500 IU
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Per capsule:
- d-alpha-Tocopheryl acid succinate 124 mg equiv. vitamin E 150 IU
- Ganoderma lucidum ext. 37.5 mg
- Lentinula edodes ext. 150 mg
- Trametes versicolor ext. 65 mg
- Curcuma longa 23.43 mg
- Cholecalciferol 12.5 μg equiv. vitamin D3 500 IU
- Selenomethionine 187.5 μg equiv. selenium 75 μg
- Zinc citrate dihydrate 23.44 mg equiv. zinc 7.5 mg
- Camellia sinensis ext. 166.7 mg
- Retinol palmitate (Vitamin A) 2.34 mg equiv. vitamin A 4250 IU equiv. vitamin A 1.28 μg RE
Practitioner product
Per tablet:
- d-alpha-Tocopheryl acid succinate 110 mg equiv. vitamin E 134 IU
- Withania somnifera ext. 60 mg
- Selenomethionine 94 μg equiv. selenium 37.5 μg
- Potassium iodide 92 μg equiv. iodine 70 μg
- Lycium barbarum ext. 300 mg
- Zingiber officinale ext. 25 mg
- Rosmarinus officinalis ext. 50 mg
- Nicotinamide (Vitamin B3) 100 mg
- Zinc sulphate monohydrate 16.5 mg equiv. zinc 6 mg
- Riboflavin (Vitamin B2) 5 mg
- Retinyl palmitate 240 μg equiv. vitamin A 130 μg RE
Practitioner product
Per tablet:
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Per capsule:
- d-alpha-Tocopheryl acid succinate 82.64 mg equiv. vitamin E 100 IU
- Tocopherols concentrate - mixed (low-alpha type) 5 mg
- Reynoutria japonica ext. 50 mg
- Vitis vinifera ext. 4.167 mg
- Ginkgo biloba ext. 6 mg
- Curcuma longa ext. 30 mg
- Vaccinium myrtillus ext. 1 mg
- Ascorbic acid (Vitamin C) 120 mg
- Silybum marianum ext. 11.43 mg
- Camellia sinensis ext. 50 mg
- Rutin (Rutoside) 100 mg
- Selenomethionine 125 μg equiv. selenium 50 μg
- Beta-carotene carotenoids (Vitamin A) 3 mg
- Glycine 50 mg
- Cysteine hydrochloride monohydrate 50 mg
- Glutamine 50 mg
- Zinc citrate dihydrate 15.58 mg equiv. zinc 5 mg
Practitioner product
Per 5 g:
- d-alpha-Tocopheryl acetate 73.5 mg equiv. vitamin E 100 IU
- Total Vitamin C 2.5 g
- Ascorbic acid (Vitamin C) 1.82 g
- Calcium ascorbate dihydrate (Vitamin C) 221 mg equiv. ascorbic acid 181.6 mg
- Sodium ascorbate (Vitamin C) 563 mg equiv. ascorbic acid 498 mg
- Rutin (Rutoside) 100 mg
- Citrus bioflavonoids extract 100 mg
- Citrus bioflavonoids extract 100 mg
- Zinc amino acid chelate 25 mg equiv. zinc 5 mg
- Beta-carotene carotenoids (Vitamin A) 4 mg
Practitioner product
Per 3.5 g (Orange):
- d-alpha-Tocopheryl acid succinate 72.7 mg equiv. vitamin E 88 IU
- Total Vitamin C 2.1 g
- Ascorbic acid (Vitamin C) 1.6 g
- Sodium ascorbate (Vitamin C) 462.6 mg equiv. ascorbic acid 411.3 mg
- Calcium ascorbate dihydrate (Vitamin C) 190.8 mg equiv. ascorbic acid 157.5 mg
- Rutin (Rutoside) 68.3 mg
- Zinc amino acid chelate 21.9 mg equiv. zinc 4.4 mg
- Beta-carotene carotenoids (Vitamin A) 1.3 mg
Practitioner product
Per 8 g (Lemon):
- d-alpha-Tocopheryl acid succinate 68 mg equiv. vitamin E 82.5 IU
- Calcium hydrogen phosphate dihydrate 601.1 mg equiv. calcium 140 mg
- Hydrolysed milk protein with Alpha-casozepine (Lactium) 75 mg
- Magnesium amino acid chelate 2.1 g equiv. magnesium 244 mg
- Sodium phosphate dibasic anhydrous 4 mg equiv. sodium 1.3 mg
- Myo-inositol 1 g
- Choline bitartrate 625.7 mg equiv. choline 257.2 mg
- Glycine 250 mg
Practitioner product
Per 6 g (Orange):
- d-alpha-Tocopheryl acid succinate 66.1 mg equiv. vitamin E 80 IU
- L-glutamine 500 mg
- Taurine 500 mg
- Magnesium amino acid chelate 2.1 g equiv. magnesium 244 mg
- Levocarnitine tartrate (L-carnitine) 75 mg equiv. levocarnitine 51.2 mg
- Thiamine hydrochloride (Vitamin B1) 25 mg
- Nicotinamide (Vitamin B3) 20 mg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 41.1 mg
- Folic acid 150 μg
- Cyanocobalamin (Vitamin B12) 18 μg
- Molybdenum trioxide 90 μg equiv. molybdenum 60 μg
- Potassium aspartate 50 mg equiv. potassium 10.5 mg
- Selenomethionine 60 μg equiv. selenium 24 μg
- Sodium phosphate dibasic anhydrous 4 mg equiv. sodium 1.3 mg
- Riboflavin (Vitamin B2) 5 mg
- Calcium pantothenate (Vitamin B5) 27.3 mg equiv. pantothenic acid 25 mg equiv. calcium 2.3 mg
- Magnesium oxide - heavy 60 mg equiv. magnesium 36.2 mg
- Calcium hydrogen phosphate dihydrate 34.3 mg equiv. calcium 8.3 mg
Practitioner product
Per 6 g:
- d-alpha-Tocopheryl acid succinate 66.1 mg equiv. vitamin E 80 IU
- L-glutamine 500 mg
- Taurine 500 mg
- Magnesium amino acid chelate 2.1 g equiv. magnesium 244 mg
- Magnesium oxide - heavy 60 mg equiv. magnesium 36.2 mg
- Levocarnitine tartrate (L-carnitine) 75 mg equiv. levocarnitine 51.2 mg
- Thiamine hydrochloride (Vitamin B1) 25 mg
- Nicotinamide (Vitamin B3) 20 mg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 41.1 mg
- Folic acid 150 μg
- Cyanocobalamin (Vitamin B12) 18 μg
- Molybdenum trioxide 90 μg equiv. molybdenum 60 μg
- Potassium aspartate 50 mg equiv. potassium 10.5 mg
- Selenomethionine 60 μg equiv. selenium 24 μg
- Riboflavin (Vitamin B2) 5 mg
- Calcium pantothenate (Vitamin B5) 27.3 mg equiv. pantothenic acid 25 mg equiv. calcium 2.3 mg
- Calcium hydrogen phosphate dihydrate 34.3 mg equiv. calcium 8.3 mg
- Sodium phosphate dibasic 4 mg equiv. sodium 1.3 mg
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Per tablet:
- d-alpha-Tocopheryl acid succinate 50 mg equiv. vitamin E 60.5 IU
- Thiamine hydrochloride (Vitamin B1) 50 mg equiv. thiamine 44.59 mg
- Riboflavin (Vitamin B2) 20 mg
- Nicotinic acid (Vitamin B3) 5 mg
- Nicotinamide (Vitamin B3) 220 mg
- Calcium pantothenate (Vitamin B5) 100 mg equiv. pantothenic acid 91.61 mg equiv. calcium 8.39 mg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 41.14 mg
- Cyanocobalamin (Vitamin B12) 100 μg
- Retinol acetate 884.62 μg equiv. vitamin A 750 μg RE
- Folic acid 150 μg
- Ascorbic acid (Vitamin C) 50 mg
- Cholecalciferol 2.5 μg equiv. vitamin D3 100 IU
- Biotin 50 μg
- Choline bitartrate 50 mg equiv. choline 20.56 mg
- L-glutamine 50 mg
- Inositol 25 mg
- Lecithin 50 mg
- Lysine hydrochloride 50 mg equiv. lysine 40 mg
- Taurine 125 mg
- Calcium hydrogen phosphate dihydrate 50 mg equiv. calcium 11.62 mg
- Chromic chloride hexahydrate 20.5 μg equiv. chromium 4 μg
- Potassium iodide (Iodine) 40.5 μg equiv. iodine 31 μg equiv. potassium 9.54 μg
- Manganese sulphate monohydrate 500 μg equiv. manganese 162.5 μg
- Magnesium phosphate pentahydrate 33.88 mg equiv. magnesium 7 mg
- Magnesium aspartate dihydrate 10.67 mg equiv. magnesium 800 μg
- Molybdenum trioxide 69.9 μg equiv. molybdenum 46.6 μg
- Potassium phosphate tribasic 30 mg equiv. potassium 14 mg
- Potassium aspartate 13.82 mg equiv. potassium 3 mg
- Zinc gluconate 110.26 mg equiv. zinc 14.4 mg
- Beta-carotene carotenoids (Vitamin A) 6 mg
- Copper sulfate pentahydrate 23.6 μg equiv. copper 6 μg
Practitioner product
Per 3.5 g:
- d-alpha-Tocopheryl acetate 41.23 mg equiv. vitamin E 56 IU
- Total Vitamin C 1.73 g
- Calcium ascorbate dihydrate (Vitamin C) 309.4 mg equiv. ascorbic acid 255.6 mg equiv. calcium 29.08 mg
- Ascorbic acid (Vitamin C) 1.085 g
- Magnesium ascorbate monohydrate (Vitamin C) 144.38 mg equiv. ascorbic acid 129.5 mg equiv. magnesium 8.96 mg
- Sodium ascorbate (Vitamin C) 187.3 mg equiv. ascorbic acid 165.6 mg equiv. sodium 21.73 mg
- Potassium ascorbate dihydrate (Vitamin C) 135.03 mg equiv. ascorbic acid 94.5 mg
- Phyllanthus emblica ext. 16.8 mg
- Rutin (Rutoside) 42 mg
- Beta-carotene carotenoids (Vitamin A) 1.26 mg
- Magnesium phosphate 70 mg equiv. magnesium 14.46 mg equiv. phosphorus 12.29 mg
- Calcium phosphate 70 mg equiv. calcium 27.13 mg equiv. phosphorus 12.95 mg
- Citrus bioflavonoids extract 70 mg
- Zinc citrate dihydrate 10.89 mg equiv. zinc 3.5 mg
- Glycine 525 mg
Practitioner product
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This monograph was last reviewed on 03/10/2024 10:00:00 and last updated on 15/05/2022 07:29:59. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
