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Safety Safety definitions

Possibly Unsafe ...when the seeds or above ground parts are used orally (18). There is insufficient reliable information available about the topical safety of yellow lupin.

Possibly Unsafe ...when used orally (18); avoid using.

Effectiveness Effectiveness definitions

There is insufficient reliable information available about the effectiveness of yellow lupin.

Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Dosing & administration

Adverse effects

General: Orally, the symptoms of poisoning following ingestion include salivation, vomiting, dysphagia, cardiac arrhythmias, ascending paralysis and possibly death due to respiratory failure (18).

Interactions with pharmaceuticals

None known.

Interactions with herbs & supplements

None known.

Interactions with foods

None known.

Interactions with lab tests

None known.

Interactions with diseases

None known.

Mechanism of action

Yellow lupin contains 0.6-1.6% quinolizidine alkaloids in the above ground plant parts, including sparteine, 13-hydroxylupanine, lupinines and p-cumaroyllupinine. The seed contain 0.4-3.3% quinolizidine alkaloids, including lupinines, sparteine, and in some cultivated strains, gramine. At present, we don't know how these components relate to the uses of lupin. Poisoning has been seen in animals, and is known as "lupinosis". It is due to the presence of mycotoxins that are produced by the fugus Phomopsis leptostromiformis, which sometimes lives in lupins (18).

References